Chitosan hydrogel/silk fibroin/Mg(OH)2 nanobiocomposite as a novel scaffold with antimicrobial activity and improved mechanical properties

Eivazzadeh‐Keihan, Reza; Radinekiyan, Fateme; Aliabadi, Hooman Aghamirza Moghim; Sukhtezari, Sima; Tahmasebi, Behnam; Maleki, Ali; Madanchi, Hamid

doi:10.1038/s41598-020-80133-3

Cited by 102 publications

(61 citation statements)

References 71 publications

(79 reference statements)

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“…This polysaccharide is highly insoluble in neutral aqueous media, but after protonation of its glucosamine amine groups, it easily changes to a soluble form [ 62 ]. Chitosan is an FDA-approved polymer with high mucoadhesive features that have been explored for biomedicine [ 63 , 64 , 65 ].…”

Section: Classification Of Hydrogelsmentioning

confidence: 99%

Smart and Biomimetic 3D and 4D Printed Composite Hydrogels: Opportunities for Different Biomedical Applications

et al. 2021

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In recent years, smart/stimuli-responsive hydrogels have drawn tremendous attention for their varied applications, mainly in the biomedical field. These hydrogels are derived from different natural and synthetic polymers but are also composite with various organic and nano-organic fillers. The basic functions of smart hydrogels rely on their ability to change behavior; functions include mechanical, swelling, shaping, hydrophilicity, and bioactivity in response to external stimuli such as temperature, pH, magnetic field, electromagnetic radiation, and biological molecules. Depending on the final applications, smart hydrogels can be processed in different geometries and modalities to meet the complicated situations in biological media, namely, injectable hydrogels (following the sol-gel transition), colloidal nano and microgels, and three dimensional (3D) printed gel constructs. In recent decades smart hydrogels have opened a new horizon for scientists to fabricate biomimetic customized biomaterials for tissue engineering, cancer therapy, wound dressing, soft robotic actuators, and controlled release of bioactive substances/drugs. Remarkably, 4D bioprinting, a newly emerged technology/concept, aims to rationally design 3D patterned biological matrices from synthesized hydrogel-based inks with the ability to change structure under stimuli. This technology has enlarged the applicability of engineered smart hydrogels and hydrogel composites in biomedical fields. This paper aims to review stimuli-responsive hydrogels according to the kinds of external changes and t recent applications in biomedical and 4D bioprinting.

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Section: Classification Of Hydrogelsmentioning

confidence: 99%

Smart and Biomimetic 3D and 4D Printed Composite Hydrogels: Opportunities for Different Biomedical Applications

et al. 2021

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“…The combination of chitosan with silk significantly improved the physicochemical properties of the obtained blends and additionally allowed imitation of the natural environment of some tissues. Obtained chitosan:silk (1:2) blend had twice the strength factor (120 MPa) of chitosan alone (60 MPa) [140]. Chitosan and silk scaffolds produced by the ultrasound technique showed porous interconnected structures which support cells adhesion and proliferation [139].…”

Section: Silkmentioning

confidence: 99%

Chitosan as an Underrated Polymer in Modern Tissue Engineering

Kołodziejska¹,

Jankowska²,

Klak³

et al. 2021

Nanomaterials

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Chitosan is one of the most well-known and characterized materials applied in tissue engineering. Due to its unique chemical, biological and physical properties chitosan is frequently used as the main component in a variety of biomaterials such as membranes, scaffolds, drug carriers, hydrogels and, lastly, as a component of bio-ink dedicated to medical applications. Chitosan’s chemical structure and presence of active chemical groups allow for modification for tailoring material to meet specific requirements according to intended use such as adequate endurance, mechanical properties or biodegradability time. Chitosan can be blended with natural (gelatin, hyaluronic acid, collagen, silk, alginate, agarose, starch, cellulose, carbon nanotubes, natural rubber latex, κ-carrageenan) and synthetic (PVA, PEO, PVP, PNIPPAm PCL, PLA, PLLA, PAA) polymers as well as with other promising materials such as aloe vera, silica, MMt and many more. Chitosan has several derivates: carboxymethylated, acylated, quaternary ammonium, thiolated, and grafted chitosan. Its versatility and comprehensiveness are confirming by further chitosan utilization as a leading constituent of innovative bio-inks applied for tissue engineering. This review examines all the aspects described above, as well as is focusing on a novel application of chitosan and its modifications, including the 3D bioprinting technique which shows great potential among other techniques applied to biomaterials fabrication.

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“…5(e)). The rst mass reduction, which is in the temperature range of 50°C to 100°C, is related to the removal of trapped water, solvents and probable impurities from the Graphene oxide-lignin/silk broin/ZnO nanobiocomposite structure (about 20%) [17]. The second mass reduction occurs in the range of 150°C to 300 and during this process, about 30% of the mass was eliminated.…”

Section: (B))mentioning

confidence: 99%

“…Furthermore, nanobiocomposites with properties such as nontoxicity, hemocompatibility, and improved mechanical properties are appropriate candidates for utilizing in biological applications and in this regard, various reports have been presented in elds of drug delivery [14], pharmaceutics [15], wound healing [16], antibacterial materials [17], cancer therapy [3,18,19], and tissue engineering [20]. A wide range of materials has been used to synthesize biological nanobiocomposites.…”

Section: -Introductionmentioning

confidence: 99%

Graphene Oxide-Lignin/Silk Fibroin/ZnO Nanobiocomposite: A Novel Bioactive Scaffold With Antibacterial Activity

Eivazzadeh‐Keihan

Zare-Bakheir

Aliabadi

et al. 2021

Preprint

Self Cite

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In this study, a novel nanobiocomposite was synthesized using graphene oxide, lignin, silk fibroin and ZnO and used in biological fields. To synthesize this structure, after preparing graphene oxide by the Hummer method, lignin, silk fibroin, and ZnO nanoparticles (NPs) were added to it, respectively. Also, ZnO NPs with a particle size of about 18 nm to 33 nm was synthesized via Camellia sinensis extract by green methodology. The synthesized structure was examined as anti-biofilm agent and it was observed that the Graphene oxide-lignin/silk fibroin/ZnO nanobiocomposite has a significant ability to prevent the formation of P. aeruginosa biofilm. In addition, due to the importance of the possibility of using this structure in biological environments, its toxicity and blood compatibility were also evaluated. According to the obtained results from MTT assay, the viability percentages of Hu02 cells treated with Graphene oxide-lignin/silk fibroin/ZnO nanobiocomposite after 24, 48, and 72 h of incubation were 89.96%, 89.32%, and 91.28%. On the other hand, the hemolysis percentage of the synthesized structure after 24 h and 72 h of extraction was 9.5% and 11.76% respectively. As a result, the synthesized structure is hemocompatible and had no toxic effects on Hu02 cells.

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Chitosan hydrogel/silk fibroin/Mg(OH)2 nanobiocomposite as a novel scaffold with antimicrobial activity and improved mechanical properties

Cited by 102 publications

References 71 publications

Smart and Biomimetic 3D and 4D Printed Composite Hydrogels: Opportunities for Different Biomedical Applications

Smart and Biomimetic 3D and 4D Printed Composite Hydrogels: Opportunities for Different Biomedical Applications

Chitosan as an Underrated Polymer in Modern Tissue Engineering

Graphene Oxide-Lignin/Silk Fibroin/ZnO Nanobiocomposite: A Novel Bioactive Scaffold With Antibacterial Activity

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