Chitosan-glucan complex hollow fibers reinforced collagen wound dressing embedded with aloe vera. II. Multifunctional properties to promote cutaneous wound healing

Abdel-Mohsen, A.M.; Franková, Jana; Abdel-Rahman, Rasha M.; Salem, A.A.; Sahffie, N.M.; Kuběna, Ivo; Jančář, J.

doi:10.1016/j.ijpharm.2020.119349

Cited by 51 publications

(28 citation statements)

References 66 publications

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“…The treatment revealed a significant improvement in the cytological and clinical indices of vaginal atrophy, demonstrating that Aloe vera can be used safely [40]. Frequently, Aloe vera powder is obtained by freeze drying [34].…”

Section: Introductionmentioning

confidence: 94%

“…Some clinical and experimental evidence suggested the usefulness of Aloe vera in wound care and wound healing for skin moisturization, promoting wound healing, thermal skin injury, and inflammatory skin pathologies [17,[23][24][25][26][27][28]. Therefore, in vitro/in vivo trials using Aloe vera gel, as a scaffold or support matrix for tissue engineering, have received considerable attention either alone or in combination with conventional drugs or natural extracts [5,11,[29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45]. For instance, the use of fresh Aloe vera gel for 10 days to treat breast soreness and irritation in lactating women produced significant wound healing [43].…”

Section: Introductionmentioning

confidence: 99%

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Characterization and Topical Study of Aloe Vera Hydrogel on Wound-Healing Process

et al. 2021

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Wound healing is fundamental to restore the tissue integrity. A topical study of the influence of Aloe vera hydrogel, formulated with 1,2-propanediol (propanediol) and triethanolamine (TEA), on the skin wound-healing process was investigated in female Wistar rats. FTIR spectroscopy confirms the presence of carboxylic acid and methyl ester carboxylate groups related with important compounds that confer the hydrogel a good interaction with proteins and growth factors. SEM images show a microstructure and micro-roughness that promote a good adhesion to the wound. Therefore, the swelling kinetics and the contact angle response contribute to the understanding of the in vivo results of the animal test. The results indicated that the Aloe vera hydrogel, prepared with propanediol and TEA, together with its superficial characteristics, improve its rapid penetration without drying out the treated tissue. This produced a positive influence on inflammation, angiogenesis, and wound contraction, reducing 29% the total healing time, reaching the total closure of the wound in 15 days.

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Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Characterization and Topical Study of Aloe Vera Hydrogel on Wound-Healing Process

et al. 2021

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“…Polysaccharides represent an indispensable source of versatile materials perceived to be superior to other polymers, due to their beneficial properties such as: Homogeneity, bio-adhesion, and bio-activity [ 76 ]. Biopolymer nanofibers such as polysaccharides fabricated via facile electrospinning technique have a series of advantages such as: Ease of processing, excellent biocompatibility, high degree of biodegradability and non-toxicity, and even an antimicrobial action as in the case of chitosan [ 16 ].…”

Section: Electrospun Nanofibers In Wound Healingmentioning

confidence: 99%

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

et al. 2020

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Currently, despite the thoroughgoing scientific research carried out in the area of wound healing management, the treatment of skin injuries, regardless of etiology remains a big provocation for health care professionals. An optimal wound dressing should be nontoxic, non-adherent, non-allergenic, should also maintain a humid medium at the wound interfacing, and be easily removed without trauma. For the development of functional and bioactive dressings, they must meet different conditions such as: The ability to remove excess exudates, to allow gaseous interchange, to behave as a barrier to microbes and to external physical or chemical aggressions, and at the same time to have the capacity of promoting the process of healing by stimulating other intricate processes such as differentiation, cell adhesion, and proliferation. Over the past several years, various types of wound dressings including hydrogels, hydrocolloids, films, foams, sponges, and micro/nanofibers have been formulated, and among them, the electrospun nanofibrous mats received an increased interest from researchers due to the numerous advantages and their intrinsic properties. The drug-embedded nanofibers are the potential candidates for wound dressing application by virtue of: Superior surface area-to volume ratio, enormous porosity (can allow oxy-permeability) or reticular nano-porosity (can inhibit the microorganisms’adhesion), structural similitude to the skin extracellular matrix, and progressive electrospinning methodology, which promotes a prolonged drug release. The reason that we chose to review the formulation of electrospun nanofibers based on polysaccharides as dressings useful in wound healing was based on the ever-growing research in this field, research that highlighted many advantages of the nanofibrillary network, but also a marked versatility in terms of numerous active substances that can be incorporated for rapid and infection-free tissue regeneration. In this review, we have extensively discussed the recent advancements performed on electrospun nanofibers (eNFs) formulation methodology as wound dressings, and we focused as well on the entrapment of different active biomolecules that have been incorporated on polysaccharides-based nanofibers, highlighting those bioagents capable of improving the healing process. In addition, in vivo tests performed to support their increased efficacy were also listed, and the advantages of the polysaccharide nanofiber-based wound dressings compared to the traditional ones were emphasized.

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“…These obtained results suggest that the encapsulation of Alv in the NFs provides an appropriate environment for cell viability and adhesion. This result could be related to the ability of Alv to improve the hydrophilicity nature and protein absorption of the NFs, which ultimately increase cell adhesion and proliferation [33,[38][39][40].…”

Section: Cell Proliferation and Cell Adhesion Studiesmentioning

confidence: 99%

A Novel Aloe Vera-Loaded Ethylcellulose/Hydroxypropyl Methylcellulose Nanofibrous Mat Designed for Wound Healing Application

et al. 2021

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Newly, the usage of nano bers (NFs) as wound dressings with the aim of their rapid healing and prevention of bacterial infection has been considered by researchers. In this regard, we produced the ethylcellulose/hydroxypropyl methylcellulose NFs incorporated with Aloe-vera (EC/HPMC/Alv) by the electrospinning technique. The produced NFs were investigated for their chemical structure, morphological, mechanical, thermal stability, degradation, swelling, cell viability, and antibacterial properties. Amongst the produced NFs, the NF samples containing 10% Alv illustrated the appropriate thermal stability and tensile properties. The produced NFs did not show any cell cytotoxicity which indicates their good compatibility. Also, NFs containing Alv signi cantly (P<0.05) increased cell proliferation and adhesion. In addition, the NFs/Alv sample was indicated antibacterial ability against S. aureus (10.21 ± 1.21 mm) and E. coli (5.06 ± 1.3 mm) pathogenic bacteria. As a result, these ndings suggest that the produced NFs could be applied as an active mat for wound dressing application.

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Chitosan-glucan complex hollow fibers reinforced collagen wound dressing embedded with aloe vera. II. Multifunctional properties to promote cutaneous wound healing

Cited by 51 publications

References 66 publications

Characterization and Topical Study of Aloe Vera Hydrogel on Wound-Healing Process

Characterization and Topical Study of Aloe Vera Hydrogel on Wound-Healing Process

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

A Novel Aloe Vera-Loaded Ethylcellulose/Hydroxypropyl Methylcellulose Nanofibrous Mat Designed for Wound Healing Application

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