Chitosan-Fibrin Nanocomposites as Drug Delivering and Wound Healing Materials

Vedakumari, Weslen S.; Prabu, P.; Sastry, T. P.

doi:10.1166/jbn.2015.1948

Cited by 40 publications

(12 citation statements)

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“…When positively charged nanomaterials come in contact with the negatively charged RBCs, they insti-gate the release of toxic substances, resulting in hemolysis. 25,26 MFNPs show good internalization potential and are hemocompatible, and hence can be employed in clinical studies and drug delivery applications. Normally, the distribution of IONPs was difficult to interpret from the results obtained via elemental analysis of Fe in blood samples due to the presence of endogenous Fe like haemoglobin, ferritin and transferrin.…”

Section: Resultsmentioning

confidence: 99%

Time-dependent biodistribution, clearance and biocompatibility of magnetic fibrin nanoparticles: an in vivo study

2015

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Recently, bioretention and toxicity of injected nanoparticles in the body has drawn much attention in biomedical research. In the present study, 5 mg Fe per kg body weight of magnetic fibrin nanoparticles (MFNPs) were injected into mice intravenously and investigated for their blood clearance profile, biodistribution, haematology and pathology studies for a time period of 28 days. Moderately long circulation of MFNPs in blood was observed with probable degradation and excretion into the bloodstream via monoatomic iron forms. Inductively coupled plasma optical emission spectrometry (ICP-OES) and Prussian blue staining results showed increased accumulation of MFNPs in the liver, followed by spleen and other organs. Body weight, spleen/thymus indexes, haematology, serum biochemistry and histopathology studies demonstrated that MFNPs were biocompatible. These results suggest the feasibility of using MFNPs for drug delivery and imaging applications.

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Section: Resultsmentioning

confidence: 99%

Time-dependent biodistribution, clearance and biocompatibility of magnetic fibrin nanoparticles: an in vivo study

2015

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“…In addition, numerous chitosan hybrid materials have been synthesized for wound healing, which comprise chitosan or carboxymethyl chitosan/gelatin hydrogels (Huang et al 2013;Patel et al 2018), chitosan/heparin/poly(γ-glutamic acid) composite hydrogels (Zhang et al 2018), chitosan-hyaluronan composite sponge scaffolds (Sanad and Abdel-Bar 2017;Tamer et al 2018), heparin-chitosan complexes (Kratz et al 1997;Kweon et al 2003), chitosan-fibrin nanocomposites (Vedakumari et al 2015), polyvinyl alcohol/chitosan/fibroin-blended sponges (Yeo et al 2000), polyvinyl alcohol/starch/chitosan hydrogels with nano zinc oxide (Baghaie et al 2017), poly(caprolactone)/chitosan/poly(vinyl alcohol) nanofibrous sponges (Gholipour-Kanani et al 2014), chitosan/poly(ethylene glycol)-tyramine hydrogels (Lih et al 2012), chitosan-alginate polyelectrolyte complexes (Wang et al 2002;Hong et al 2008;Caetano et al 2015;Kong et al 2016), porous keratin/chitosan scaffolds without and with zinc oxide (Tan et al 2015;Zhai et al 2018), nanotitanium oxide/chitosan complexes (Peng et al 2008), chitosan/collagen hydrogels and sponges (Wang et al 2008a;Cui et al 2011;Ti et al 2015), chitosan green tea polyphenol complexes (Qin et al 2010(Qin et al , 2013, dextran hydrogels loaded with chitosan microparticles (Ribeiro et al 2013), chitosan/polycaprolactone scaffolds (Bai et al 2014;Zhou et al 2017b), chitosan oleate ionic micelles (Dellera et al 2014), castor oil polymeric films reinforced with chitosan/zinc oxide nanoparticles (Diez-Pascual and Diez-Vicente 2015), sponge-like nano-silver/zinc oxide-loaded chitosan composites (Lu et al 2017), gellan gum-chitosan hydrogels (Shukla et al 2016), chitosan-silica hybrid dressing materials…”

Section: Cutaneous Wound Healingmentioning

confidence: 99%

Chitin/Chitosan: Versatile Ecological, Industrial, and Biomedical Applications

Merzendorfer

Cohen

2019

Biologically-Inspired Systems

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Chitin is a linear polysaccharide of N-acetylglucosamine, which is highly abundant in nature and mainly produced by marine crustaceans. Chitosan is obtained by hydrolytic deacetylation. Both polysaccharides are renewable resources, simply and cost-effectively extracted from waste material of fish industry, mainly crab and shrimp shells. Research over the past five decades has revealed that chitosan, in particular, possesses unique and useful characteristics such as chemical versatility, polyelectrolyte properties, gel-and film-forming ability, high adsorption capacity, antimicrobial and antioxidative properties, low toxicity, and biocompatibility and biodegradability features. A plethora of chemical chitosan derivatives have been synthesized yielding improved materials with suggested or effective applications in water treatment, biosensor engineering, agriculture, food processing and storage, textile additives, cosmetics fabrication, and in veterinary and human medicine. The number of studies in this research field has exploded particularly during the last two decades. Here, we review recent advances in utilizing chitosan and chitosan derivatives in different technical, agricultural, and biomedical fields.

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“…4,5 However, fibrin gels resulting from fibrinogen and thrombin mixtures without Factor XIII in vitro show moderate mechanical properties and fast biodegradability, which limit their range of applications as biomaterials. 6,7 To address this point, an increasing amount of studies focus on fibrin-based mixed or composite hydrogels incorporating other biopolymers, such as chitosan, 8,9 gelatin, 10,11 collagen, [12][13][14][15] alginate, 16,17 or (oxidized) cellulose, [18][19][20] that are used in wound healing, drug delivery, bone regeneration and tissue engineering. Among these, oxidized cellulose is of particular interest because it is, like fibrin, a hemostatic agent that can accelerate blood coagulation by immediately extracting fluid from the blood and entrapping blood proteins, platelets, red blood cells, and other active ingredients.…”

Section: Introductionmentioning

confidence: 99%

Cellulose Nanocrystal–Fibrin Nanocomposite Hydrogels Promoting Myotube Formation

et al. 2021

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Cellulose Nanocrystals have been widely studied as fillers to form reinforced nanocomposites with a wide range of applications, including the biomedical area. Here, we evaluated the possibility to combine them with fibrinogen and obtain fibrin hydrogels with improved mechanical stability as potential cellular scaffolds. In diluted conditions at neutral pH, it was evidenced that fibrinogen could adsorb on cellulose nanocrystals in a two-step process, favoring their alignment under flow. Composite hydrogels could be prepared from concentrated fibrinogen solutions and nanocrystals amounts up to 0.3 w%. Cellulose nanocrystals induced a significant modification of initial fibrin fibrillogenesis and final fibrin network structure, and storage moduli of all nanocomposites were larger than that of pure fibrin hydrogels. Moreover, optimal conditions were found that promoted muscle cells differentiation and formation of long myotubes. These results provide original insights on the interactions of cellulose nanocrystals with proteins with key physiological functions and offer new perspectives for the design of injectable fibrin-based formulations.

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Chitosan-Fibrin Nanocomposites as Drug Delivering and Wound Healing Materials

Cited by 40 publications

References 0 publications

Time-dependent biodistribution, clearance and biocompatibility of magnetic fibrin nanoparticles: an in vivo study

Time-dependent biodistribution, clearance and biocompatibility of magnetic fibrin nanoparticles: an in vivo study

Chitin/Chitosan: Versatile Ecological, Industrial, and Biomedical Applications

Cellulose Nanocrystal–Fibrin Nanocomposite Hydrogels Promoting Myotube Formation

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