Time-dependent biodistribution, clearance and biocompatibility of magnetic fibrin nanoparticles: an in vivo study

Prabu, P.; Vedakumari, Weslen S.; Sastry, T. P.

doi:10.1039/c5nr00113g

Cited by 14 publications

(9 citation statements)

References 41 publications

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“…When BP nanoparticles were systemically administered, various serum proteins bound to their surface to form large particles, which were recognized by the scavenger receptors on the macrophages. BP NPs were mainly enriched in liver and spleen because they were exogenous and easily captured by the macrophages in these organs. , In contrast to liver and spleen, the uptakes of BP-DEX NPs in heart, lung, and kidney are much smaller. Larger microsized particles are usually captured by lung, and ultrasmall nanoparticles (less than 6 nm) are directly excreted via kidney. , The distribution of BP-DEX NPs in major organs at 24 h post injection is shown in Figure S-15, which follows an order of spleen > liver > lung > kidney.…”

Section: Resultsmentioning

confidence: 99%

“…BP NPs were mainly enriched in liver and spleen because they were exogenous and easily captured by the macrophages in these organs. 53,54 In contrast to liver and spleen, the uptakes of BP-DEX NPs in heart, lung, and kidney are much smaller. Larger microsized particles are usually captured by lung, and ultrasmall nanoparticles (less than 6 nm) are directly excreted via kidney.…”

Section: Acs Applied Bio Materialsmentioning

confidence: 99%

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Blood Circulation, Biodistribution, and Pharmacokinetics of Dextran-Modified Black Phosphorus Nanoparticles

Sun

Deng

et al. 2018

ACS Appl. Bio Mater.

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Black phosphorus (BP) nanostructures have been receiving enormous attention in diverse bioapplications owing to their unique physicochemical properties. However, it is still challenging to investigate their blood circulation, biodistribution, and pharmacokinetics after administration due to the difficulty in quantifying them. Here, we report the quantification of blood circulation, biodistribution, and pharmacokinetics of dextran-modified BP nanoparticles (i.e., BP-DEX NPs) in balb/c mice through the highly sensitive noninvasive photoacoustic (PA) imaging and single-emission computed tomography/computed tomography (SPECT/CT) imaging. We first prepare water-soluble and biocompatible small BP-DEX NPs and label them with radioisotopes 99m Tc. We then quantify their half-lives of distribution and elimination phases to be 0.2 and 9.5 h by counting the γ-emissions in the blood of mice administrated with BP-DEX NPs. We also show the dynamic variation of BP-DEX NPs in the tumor, liver, spleen, and kidney through in vivo PA imaging and illustrate the accumulation of nanoparticles in major organs by SPECT/CT imaging, which follows an order of spleen > liver > lung > kidney. Our work demonstrates the renal clearance and hepatobiliary excretion of BP-DEX NPs, which could be potentially translated for clinical in vivo imaging and therapy of cancer.

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Section: Resultsmentioning

confidence: 99%

Section: Acs Applied Bio Materialsmentioning

confidence: 99%

Blood Circulation, Biodistribution, and Pharmacokinetics of Dextran-Modified Black Phosphorus Nanoparticles

Sun

Deng

et al. 2018

ACS Appl. Bio Mater.

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“…Tail moment (µm) (mean ± SE) Group 1 (control) (muscles) 5.7 ± 1.4 a 4.8 ± 0.5 a 0.3 ± 0. 10.9 ± 1.1 b, c,* 8.9 ± 1.0 a 1.0 ± 0.3 a, b,* more than other organs as demonstrated by histopathological analysis [41].…”

Section: Groupsmentioning

confidence: 85%

Tissue Distribution, Histopathological and Genotoxic Effects of Magnetite Nanoparticles on Ehrlich Solid Carcinoma

Bassiony

El-Ghor

Salaheldin

et al. 2022

Biol Trace Elem Res

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Nanoparticles can potentially cause adverse effects on cellular and molecular level. The present study aimed to investigate the histopathological changes and DNA damage effects of magnetite nanoparticles (MNPs) on female albino mice model with Ehrlich solid carcinoma (ESC). Magnetite nanoparticles coated with L-ascorbic acid (size ~ 25.0 nm) were synthesized and characterized. Mice were treated with MNPs day by day, intraperitoneally (IP), intramuscularly (IM), or intratumorally (IT). Autopsy samples were taken from the solid tumor, thigh muscle, liver, kidney, lung, spleen, and brain for assessment of iron content, histopathological examination, and genotoxicity using comet assay. The liver, spleen, lung, and heart had significantly higher iron content in groups treated IP. On the other hand, tumor, muscles, and the liver had significantly higher iron content in groups treated IT. MNPs induced a significant DNA damage in IT treated ESC. While a significant DNA damage was detected in the liver of the IP treated group, but no significant DNA damage could be detected in the brain. Histopathological findings in ESC revealed a marked tumor necrosis, 50% in group injected IT but 40% in group injected IP and 20% only in untreated tumors. Other findings include inflammatory cell infiltration, dilatation, and congestion of blood vessels of different organs of treated groups in addition to appearance of metastatic cancer cells in the liver of non-treated tumor group. MNPs could have an antitumor effect but it is recommended to be injected intratumorally to be directed to the tumor tissues and reduce its adverse effects on healthy tissues.

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“…Beyond showing complete destruction of a thrombus in the HIFU focal zone in as little as 15 s in a flow model, destruction of clots using P@hMSNs produced far fewer microemboli than both direct mechanical thrombectomy and other HIFU treatments. We also show that this microembolic matter was converted to “nano-embolic” matter, which should be harmless as it shares many compositional similarities as nanoscale drug delivery vehicles and naturally forming fibrin protofibrils. − Thus, P@hMSNs represent a type of contrast agent that can destroy occlusive blood clots safely and completely with minimal risk of postprocedure side effects.…”

Section: Introductionmentioning

confidence: 90%

Phospholipid-Coated Hydrophobic Mesoporous Silica Nanoparticles Enhance Thrombectomy by High-Intensity Focused Ultrasound with Low Production of Embolism-Inducing Clot Debris

Blum

Gyorkos

Narowetz

et al. 2019

ACS Appl. Mater. Interfaces

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Here we report the efficacy of a nanoparticleassisted high-intensity focused ultrasound (HIFU) treatment that selectively destroys blood clots while minimizing generation of microparticles, or microemboli, that can cause further complications postsurgery. Treatment of malignant blood clots (thrombi) and the resulting emboli are critical problems for numerous patients, and treatments addressing these conditions would benefit from advancements in noninvasive procedures such as HIFU. While recanalization of occlusive blood clots is currently addressed with surgical intervention that seeks to minimize formation of large emboli, there is a danger of microemboli (micrometer-size particles) that have been theorized to be responsible for the poor correlation between apparent surgical success and patient outcome. Here, the addition of phospholipid-coated hydrophobically modified silica nanoparticles (P@hMSNs) improved the efficacy of HIFU treatment by serving as cavitation nuclei for mechanical disruption of thrombi. This treatment was evaluated for the ability to clear the HIFU focal area of a thick and dense thrombus within 10 min. Moreover, it was found that the use of P@hMSN+HIFU treatment generated a significantly smaller microembolic load as compared to comparison techniques, including a HIFU + microbubble contrast agent, HIFU alone, and direct mechanical disruption. This reduction in the microembolic load can occur either with primary removal of the clot by P@ hMSN+HIFU or by insonation of the clot fragments after mechanical thrombectomy. Lastly, this method was evaluated in a flow model, where nonocclusive model thrombi and model emboli were mechanically ablated within the focal area within 15 s. Together, these results represent a combination therapy capable of resolving thrombi and microembolisms resulting from thrombectomy through localized destruction of clotted material.

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Time-dependent biodistribution, clearance and biocompatibility of magnetic fibrin nanoparticles: an in vivo study

Cited by 14 publications

References 41 publications

Blood Circulation, Biodistribution, and Pharmacokinetics of Dextran-Modified Black Phosphorus Nanoparticles

Blood Circulation, Biodistribution, and Pharmacokinetics of Dextran-Modified Black Phosphorus Nanoparticles

Tissue Distribution, Histopathological and Genotoxic Effects of Magnetite Nanoparticles on Ehrlich Solid Carcinoma

Phospholipid-Coated Hydrophobic Mesoporous Silica Nanoparticles Enhance Thrombectomy by High-Intensity Focused Ultrasound with Low Production of Embolism-Inducing Clot Debris

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