Cellulose Nanocrystal–Fibrin Nanocomposite Hydrogels Promoting Myotube Formation

Wang, Kun; Mosser, Gervaise; Haye, Bernard; Baccile, Niki; Griel, Patrick Le; Pernot, Pétra; Cathala, Bernard; Trichet, Léa; Coradin, Thibaud

doi:10.1021/acs.biomac.1c00422

Cited by 13 publications

(8 citation statements)

References 65 publications

(106 reference statements)

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“…Therefore, it is recognized by some researchers as a highly efficient choice for drug carriers, whether via in vivo or in vitro delivery routes ( Kehr et al, 2015 ; Du et al, 2021 ). In addition, NHs also have outstanding biomimetic properties and histocompatibility, so they can place some special tissues for clinical treatment, such as cartilage, skeletal muscle, and cardiac tissues ( Asadi et al, 2018 ; Piantanida et al, 2019 ; Zhao et al, 2020 ; Peper et al, 2021 ; Wang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

A Bibliometric and Visual Analysis of Nanocomposite Hydrogels Based on VOSviewer From 2010 to 2022

Zhao

Zhang

2022

Front. Bioeng. Biotechnol.

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Background: Nanocomposite hydrogels (NHs) are stable composite materials formed by dispersing nanomaterials in hydrogels and have broad development prospects in the biomedical field. In this study, we aimed to systematically and comprehensively evaluate the trends and hot spots of biomedical applications of NHs from 2010 to 2022.Methods: In total, 713 articles and reviews related to NH applications in the biomedical field from 2010 to 2022 were retrieved from the Web of Science Core Collection (WOSCC). Two scientometric software programs, VOSviewer and Microsoft Excel 2019, were used to visually perform bibliometric analysis in terms of research trends, sources, the contribution of journals, co-citation, and the co-occurrence of keywords.Results: From 1 January 2010 to 3 February 2022, the number of annual scientific publications about NHs exhibited an upward trend, and research articles were published in a larger proportion (more than 77%). The top three countries in NH research were China, the United States, and India. Meanwhile, Tabriz University of Medical Sciences, the Chinese Academy of Sciences, and Tshwane University of Technology were the most active and contributive. In the contribution of journals, the journal Advanced Functional Materials had the highest number of publications, and the journal Int J Biol Macro had the most citations. Varaprasad K was the most prolific author, and Haraguchi K ranked first among co-cited authors. In the ranking of frequency in the co-cited references, Nanocomposite Hydrogels for Biomedical Applications, published by Gaharwar AK, was the most frequently cited reference. The keyword with the highest frequency was “drug delivery.”Conclusion: This study performed a full overview of NHs using bibliometrics and identified current trends and hot spots. This information may help researchers focusing on NHs to identify developments in this field.

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Section: Introductionmentioning

confidence: 99%

A Bibliometric and Visual Analysis of Nanocomposite Hydrogels Based on VOSviewer From 2010 to 2022

Zhao

Zhang

2022

Front. Bioeng. Biotechnol.

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“…In a further step, the ability of seeded cells to differentiate and form myotubes was studied. It was noticed that pure fibrin gel obtained by the acidic route yields to fewer and shorter myotubes compared to fibrin gels obtained using the common neutral pH route, although C2C12 proliferation rates were similar for both types of gels [ 13 ]. This points out that, although the acidic pathway does allow obtaining fibrin networks, they have distinct structures and properties from common ones [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…In vitro, in the absence of factor XIII, fibrin hydrogels usually show fast biodegradability and low storage modulus values [ 5 , 6 ]. There are many approaches to solve these problems, such as increasing fibrinogen and thrombin concentration [ 7 , 8 ], adding chemical cross-linkers [ 9 , 10 ] or mixing fibrinogen with particles or other polymers to form composite hydrogels [ 11 , 12 , 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Fibrin-Type I Collagen Biomaterials via an Acidic Gel

et al. 2022

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Fibrin-Type I collagen composite gels have been widely studied as biomaterials, in which both networks are usually formed simultaneously at a neutral pH. Here, we describe a new protocol in which mixed concentrated solutions of collagen and fibrinogen were first incubated at acidic pH to induce fibrinogen gel formation, followed by a pH change to neutral inducing collagen fiber formation. Thrombin was then added to form fibrin-collagen networks. Using this protocol, mixed gels containing 20 mg.mL−1 fibrin and up to 10 mg.mL−1 collagen could be prepared. Macroscopic observations evidenced that increasing the content of collagen increases the turbidity of the gels and decreases their shrinkage during the fibrinogen-to-fibrin conversion. The presence of collagen had a minor influence on the rheological properties of the gels. Electron microscopy allowed for observation of collagen fibers within the fibrin network. 2D cultures of C2C12 myoblasts on mixed gels revealed that the presence of collagen favors proliferation and local alignment of the cells. However, it interferes with cell differentiation and myotube formation, suggesting that further control of in-gel collagen self-assembly is required to elaborate fully functional biomaterials.

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“…Development of fibrin based composite hydrogels supplemented with different types polymer materials could be an effective strategy. Recently, Wang K. et al (2021) combined cellulose nanocrystals (CNC) with fibrinogen and obtained CNC reinforced fibrin nanocomposite hydrogel, and the obtained hydrogel with improved mechanical stability showed an improvement in the formation of long myotubes (up to 800 μm).…”

Section: Transglutaminase Catalysed Formation Of Polymer Hydrogelmentioning

confidence: 99%

Transglutaminase-Catalyzed Bottom-Up Synthesis of Polymer Hydrogel

Lai

Bao

Zhu

et al. 2022

Front. Bioeng. Biotechnol.

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Enzyme catalysis has attracted increasing attention for application in the synthesis of polymer hydrogel due to the eco-friendly process and the devisable catalytic reaction. Moreover, bottom-up approaches combining enzyme catalysts and molecular self-assembly have been explored for synthesizing hydrogel with complex architectures. An enzyme widely distributed in nature, transglutaminase (TGase) has been confirmed to catalyze the formation of isopeptide bonds between proteins, which can effectively improve the gelation of proteins. In this mini-review, TGase-catalyzed synthesis of polymer hydrogels, including fibrin hydrogels, polyethylene glycol hydrogels, soy protein hydrogels, collagen hydrogels, gelatin hydrogels and hyaluronan hydrogels, has been reviewed in detail. The catalytic process and gel formation mechanism by TGase have also been considered. Furthermore, future perspectives and challenges in the preparation of polymer hydrogels by TGase are also highlighted.

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Cellulose Nanocrystal–Fibrin Nanocomposite Hydrogels Promoting Myotube Formation

Cited by 13 publications

References 65 publications

A Bibliometric and Visual Analysis of Nanocomposite Hydrogels Based on VOSviewer From 2010 to 2022

A Bibliometric and Visual Analysis of Nanocomposite Hydrogels Based on VOSviewer From 2010 to 2022

Synthesis of Fibrin-Type I Collagen Biomaterials via an Acidic Gel

Transglutaminase-Catalyzed Bottom-Up Synthesis of Polymer Hydrogel

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