Chitosan/carboxymethyl cellulose wound dressings supplemented with biologically synthesized silver nanoparticles from the ligninolytic fungus Anamorphous Bjerkandera sp. R1

Echavarría, Jerónimo Osorio; Vanegas, Natalia Andrea Gómez; Orozco, Claudia Patricia Ossa

doi:10.1016/j.heliyon.2022.e10258

Cited by 15 publications

(5 citation statements)

References 85 publications

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“…In addition, the timing of wound healing is critical for preventing abnormal tissue regeneration 9 . Consequently, several studies were conducted involving the use of natural polymers like chitin, 10 chitosan, 11 alginate, 12 Carboxymethyl cellulose, 13 and pectin 14 to develop wound dressings. As well as preventing bacterial infections, wound dressings maintain a moist environment in the wound, absorb excessive exudate, and accelerate tissue regeneration 4 .…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of carboxymethyl cellulose/polyethylene glycol films containing bromelain/curcumin: In vitro evaluation of wound healing activity

Mojahedi,

Zargar Kharazi,

Poorazizi

2024

Polymer Engineering & Sci

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In this study, a wound‐healing membrane was fabricated based on carboxymethyl cellulose (CMC) and polyethylene glycol (PEG) containing curcumin (Cur) and bromelain (Br). Citric acid (CA) was used as a cross‐linking agent. This membrane showed an ideal degree of swelling, which was significantly dependent on the concentration and duration of cross‐linked CA. The chemical characterization showed the CA cross‐linker mechanism was more associated with chemical reactions with CMC carboxyl groups, and PEG hydroxyl groups played an important role in forming a hybrid polymer network. It greatly enhanced mechanical and adhesive properties, so the stress strength was improved from 29.4 to 38.52 Mpa. The hydrophilicity of the membrane surface according to the water contact angle assay showed the membrane surface is suitable for adhesion, growth, migration, and proliferation of skin cells. The drug delivery assay demonstrated that the Br and Cur were released during 48 h, but the Br followed the burst release in comparison with Cur. Antibacterial properties showed that CMC/PEG‐Cur/Br have ideal antibacterial properties for preventing the growth of bacteria. In summary, the engineered CMC/PEG containing Cur/Br films with desired cell viability properties and antibacterial activity can potentially improve and accelerate skin regeneration for chronic wound healing.Highlights Hydrogel film was prepared based on carboxymethyl cellulose (CMC), polyethylene glycol (PEG), and citric acid as cross‐linking agent. CMC/PEG film were induced controlling curcumin (Cur) and bromelain (Br) release for wound healing process. CMC/PEG film revealed a wide range of physiochemical, mechanical, adhesion, and biological properties behavior. Incorporation of Cur and Br promoted in vitro biocompatibility, L‐929 cells attachments, and cell migration.

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Section: Introductionmentioning

confidence: 99%

Preparation and characterization of carboxymethyl cellulose/polyethylene glycol films containing bromelain/curcumin: In vitro evaluation of wound healing activity

Mojahedi,

Zargar Kharazi,

Poorazizi

2024

Polymer Engineering & Sci

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“…These qualities include the stimulation of fibroblast proliferation, the production of collagen, the enhancement of inflammatory cell activities, and the engagement of integrins. Hence, it is imperative to undertake chemical alterations to the structure of CS in order to enhance its physicochemical qualities for further utilisation [ 12 , 38 , 39 ]. The CS polymer is a modified form of CS that exhibits the ability to interact with cells, leading to favourable outcomes in terms of cell development and wound healing.…”

Section: Introductionmentioning

confidence: 99%

Facile fabrication and biological investigations of metal oxides intercalated in kaolinite clay-based dressing material to improve wound healing ability in nursing care after post-operative period

Cheng,

Yao,

Fan

et al. 2024

Heliyon

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“…[ 15,16 ] Chitosan and its derivatives, as the most abundant amino polysaccharides in nature, could create a polyelectrolyte complex by creating a strong bond with materials with opposite charges. [ 17 ] Biological properties such as bio‐adhesion, anti‐cancer, antibacterial, reducing inflammation and pain, antioxidant, and blood coagulant (hemostatic) have distinguished chitosan from other natural polymers. Also, due to its adhesive properties, chitosan can be used effectively in connecting hard and soft tissues.…”

Section: Introductionmentioning

confidence: 99%

“…Echavarría et al. [ 17 ] showed that chitosan and CMC hydrogels combined with silver nanoparticles have good mechanical properties and antibacterial activity against Escherichia coli (E. coli) . This compound can be used as a bioadhesive without any toxicity against bleeding.…”

Section: Introductionmentioning

confidence: 99%

Engineering Wet‐Resistant and Osteogenic Nanocomposite Adhesive to Control Bleeding and Infection after Median Sternotomy

Shokri,

Kharaziha,

Ahmadi Tafti

et al. 2024

Adv Healthcare Materials

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Median sternotomy surgery stands as one of the prevailing strategies in cardiac surgery. In this study, the cutting‐edge bone adhesive is designed, inspired by the impressive adhesive properties found in mussels and sandcastle worms. We have created an osteogenic nanocomposite coacervate adhesive by integrating a cellulose‐polyphosphodopamide interpenetrating network, quaternized chitosan, and zinc, gallium‐doped hydroxyapatite nanoparticles. This adhesive is characterized by robust catechol–metal coordination which effectively adheres to both hard and soft tissues with a maximum adhesive strength of 900 ±38 kPa on the sheep sternum bone, surpassing that of commercial bone adhesives. The release of zinc and gallium cations from nanocomposite adhesives and quaternized chitosan matrix imparts remarkable antibacterial properties and promotes rapid blood coagulation, in vitro and ex vivo. It is also proved that this nanocomposite adhesive exhibits significant in vitro bioactivity, stable degradability, biocompatibility, and osteogenic ability. Furthermore, the capacity of nanocomposite coacervate to adhere to bone tissue and support osteogenesis contributes to the successful healing of a sternum bone defect in a rabbit model in vivo. In summary, these nanocomposite coacervate adhesives with promising characteristics are expected to provide solutions to clinical issues faced during median sternotomy surgery.This article is protected by copyright. All rights reserved

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Chitosan/carboxymethyl cellulose wound dressings supplemented with biologically synthesized silver nanoparticles from the ligninolytic fungus Anamorphous Bjerkandera sp. R1

Cited by 15 publications

References 85 publications

Preparation and characterization of carboxymethyl cellulose/polyethylene glycol films containing bromelain/curcumin: In vitro evaluation of wound healing activity

Preparation and characterization of carboxymethyl cellulose/polyethylene glycol films containing bromelain/curcumin: In vitro evaluation of wound healing activity

Facile fabrication and biological investigations of metal oxides intercalated in kaolinite clay-based dressing material to improve wound healing ability in nursing care after post-operative period

Engineering Wet‐Resistant and Osteogenic Nanocomposite Adhesive to Control Bleeding and Infection after Median Sternotomy

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