Chitosan based supramolecular polypseudorotaxane as a pH-responsive polymer and their hybridization with mesoporous silica-coated magnetic graphene oxide for triggered anticancer drug delivery

Pourjavadi, Ali; Tehrani, Zahra Mazaheri; Jokar, Safura

doi:10.1016/j.polymer.2015.08.050

Cited by 47 publications

(13 citation statements)

References 48 publications

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“…Chitosan can be directly adsorbed by hydrogen bonding onto the surface to form a single protective layer. When pH drops, the amine groups get protonated, and the polymer shell swells reversely, allowing the release and making it a good on/off pH-responsive system [ 140 , 141 , 142 , 143 ]. The covalent bonding of chitosan onto the surface through cross-linking chemistry has also been reported [ 155 , 156 , 157 , 158 ].…”

Section: Supramolecular Structures As Pore-capping Agentsmentioning

confidence: 99%

pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

2017

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The application of nanotechnology to medicine constitutes a major field of research nowadays. In particular, the use of mesoporous silica and carbon nanoparticles has attracted the attention of numerous researchers due to their unique properties, especially when applied to cancer treatment. Many strategies based on stimuli-responsive nanocarriers have been developed to control the drug release and avoid premature release. Here, we focus on the use of the subtle changes of pH between healthy and diseased areas along the body to trigger the release of the cargo. In this review, different approximations of pH-responsive systems are considered: those based on the use of the host-guest interactions between the nanocarriers and the drugs, those based on the hydrolysis of acid-labile bonds and those based on supramolecular structures acting as pore capping agents.

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Section: Supramolecular Structures As Pore-capping Agentsmentioning

confidence: 99%

pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

2017

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“…Recently, graphene-based hybrids, especially graphene-metal or metal-oxide nanoparticles hybrids have attracted considerable attention due to their ability to impart multifunctional properties to polymer nanocomposites [2][3][4][5][6][7]. The synergistic effects of graphene and functional nanoparticles may result in enhanced properties which favour their application in catalysis [5], energy storage [6], and electromagnetic wave absorption [7].…”

Section: Introductionmentioning

confidence: 99%

A novel route for tethering graphene with iron oxide and its magnetic field alignment in polymer nanocomposites

Zhang

Ladani

et al. 2016

Polymer

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We present a new route for tethering graphene nanoplatelets (GNPs) with Fe 3 O 4 nanoparticles to enable their alignment in an epoxy using a weak magnetic field. The GNPs are first stabilised in water using poly(vinylpyrrolidone) (PVP) and Fe 3 O 4 nanoparticles are then attached via coprecipitation. The resultant Fe 3 O 4 /PVP-GNPs nanohybrids are superparamagnetic and can be aligned in an epoxy resin, before gelation, by applying a weak magnetic field as low as 0.009 T.A theoretical model describing the alignment process is presented. The resulting nanocomposites exhibit anisotropic properties with significantly improved electrical conductivities (three orders of magnitude) in the alignment direction and dramatically increased fracture energy (about 530%) when the nanohybrids are aligned transverse to the crack growth direction, compared with the unmodified epoxy. Compared with the randomly-oriented nanocomposites, these aligned nanocomposites show approximately 50% increase in toughness transverse to the alignment direction and a seven-fold increase in electrical conductivity in the alignment direction.

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“…The extent of drug release can be controlled by changing the pH and the bursting of shell at 5.5 pH showed maximum release. Furthermore, this coreshell nanocomposite is quite soluble and formed stable colloid in biological fluids [4]. Hydrophobic drugs can also be delivered to the tumor cells using GO.…”

Section: Drug Delivery and Cancer Therapymentioning

confidence: 99%

Graphene Oxide for Biomedical Applications

K¹,

Modak²,

Paik³

2017

JNMR

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Graphene oxide (GO) is one of the most promising functional materials used in various applications like energy storage (batteries and supercapacitors) sensors, photocatalysis, electronics and in biomedicine. The last 10 years literature on GO for biomedical applications revealed and confirmed the scope of its potential capabilities as biomaterial. GO alone and its modified form with different materials (surface functionalization, immobilization of nanoparticles and composite formation) also proved as a multifunctional candidate for medical biotechnology. A material for its use in biomedical applications must be biocompatible and nontoxic to the living cells.. Although there are some concerns about the toxicity of the GO in specific cases, a dosage range and size effects reported in the literature to use it as a nontoxic materials. In view of all these points, an effort has been made to review and emphasize the scope of GO as a biomedical agent for the applications like targeted drug delivery, cancer theranostics, bioimaging and biosensors etc. Further, potential applications along with the future scope and limitations of GO have also been highlighted in this review.

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Chitosan based supramolecular polypseudorotaxane as a pH-responsive polymer and their hybridization with mesoporous silica-coated magnetic graphene oxide for triggered anticancer drug delivery

Cited by 47 publications

References 48 publications

pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

A novel route for tethering graphene with iron oxide and its magnetic field alignment in polymer nanocomposites

Graphene Oxide for Biomedical Applications

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