pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

Gisbert-Garzarán, Miguel; Manzano, Miguel; Vallet‐Regí, María

doi:10.3390/bioengineering4010003

Cited by 62 publications

(40 citation statements)

References 206 publications

(211 reference statements)

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“…These drug loading results show the extraordinary capability of GYSMNP@PF127 to load high contents of DOX on its high surface area. This ability can be ascribed to the π-π stacking interactions between the aromatic rings of DOX and the carbonaceous structure of graphene-based nanoshells [50], as well as to some surface groups. The post-synthetic functionalization of GYSMNP allowed a high negative surface charge (zeta potential values ca.…”

Section: Dox Loading Studiesmentioning

confidence: 99%

Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery

Rodrigues

Baldi

Doumett

et al. 2018

Materials Science and Engineering: C

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The synthesis of hydrophilic graphene-based yolk-shell magnetic nanoparticles functionalized with copolymer pluronic F-127 (GYSMNP@PF127) is herein reported to achieve an efficient multifunctional biomedical system for mild hyperthermia and stimuli-responsive drug delivery. In vitro tests revealed the extraordinary ability of GYSMNP@PF127 to act as smart stimuli-responsive multifunctional nanomedicine platform for cancer therapy, exhibiting (i) an outstanding loading capacity of 91% (w/w, representing 910 μg mg −1) of the chemotherapeutic drug doxorubicin, (ii) a high heating efficiency under an alternating (AC) magnetic field (intrinsic power loss ranging from 2.1-2.7 nHm 2 kg −1), and (iii) a dual pH and thermal stimuli-responsive drug controlled release (46% at acidic tumour pH vs 7% at physiological pH) under AC magnetic field, in just 30 min. Additionally, GYSMNP@PF127 presents optimal hydrodynamic diameter (D H = 180 nm) with negative surface charge, high haemocompatibility for blood stream applications and tumour cellular uptake of drug nanocarriers. Due to its physicochemical, magnetic and biocompatibility properties, the developed graphene-based magnetic nanocarrier shows high promise as dual exogenous (AC field)/endogenous (pH) stimuli-responsive actuators for targeted thermo-chemotherapy, combining magnetic hyperthermia and controlled drug release triggered by the abnormal tumour environment. The presented strategy and findings can represent a new way to design and develop highly stable added-value graphene-based nanostructures for the combined treatment of cancer.

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Section: Dox Loading Studiesmentioning

confidence: 99%

Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery

Rodrigues

Baldi

Doumett

et al. 2018

Materials Science and Engineering: C

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“…In wound healing, the pH value is suggested as a parameter for both diagnostic and theranostic purposes [8]. Moreover, recent advances in the field of stimuli-responsive drug delivery [9,10] allow for utilization of the pH as an endogenous trigger for drug release in wound healing [11] and solid tumors [9,12,13].…”

Section: Introductionmentioning

confidence: 99%

Early pH Changes in Musculoskeletal Tissues upon Injury—Aerobic Catabolic Pathway Activity Linked to Inter-Individual Differences in Local pH

Berkmann

Martin

Ellinghaus

et al. 2020

IJMS

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Local pH is stated to acidify after bone fracture. However, the time course and degree of acidification remain unknown. Whether the acidification pattern within a fracture hematoma is applicable to adjacent muscle hematoma or is exclusive to this regenerative tissue has not been studied to date. Thus, in this study, we aimed to unravel the extent and pattern of acidification in vivo during the early phase post musculoskeletal injury. Local pH changes after fracture and muscle trauma were measured simultaneously in two pre-clinical animal models (sheep/rats) immediately after and up to 48 h post injury. The rat fracture hematoma was further analyzed histologically and metabolomically. In vivo pH measurements in bone and muscle hematoma revealed a local acidification in both animal models, yielding mean pH values in rats of 6.69 and 6.89, with pronounced intra- and inter-individual differences. The metabolomic analysis of the hematomas indicated a link between reduction in tricarboxylic acid cycle activity and pH, thus, metabolic activity within the injured tissues could be causative for the different pH values. The significant acidification within the early musculoskeletal hematoma could enable the employment of the pH for novel, sought-after treatments that allow for spatially and temporally controlled drug release.

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“…However, this also means that the cargo molecules might easily diffuse out of the pores before reaching the target area. This premature release can be minimized using the so-called stimuli-responsive gatekeepers, which are structures able to open and close the pore entrances on-demand in response to certain stimuli [16,[50][51][52]. In this manner, premature and non-specific drug release would be minimized, and the release would only take place upon application of a convenient stimulus at the diseased area ( Figure 2).…”

Section: Mesoporous Silica Nanoparticles As Smart Drug Delivery Systemsmentioning

confidence: 99%

Mesoporous Silica Nanoparticles for the Treatment of Complex Bone Diseases: Bone Cancer, Bone Infection and Osteoporosis

2020

Self Cite

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Bone diseases, such as bone cancer, bone infection and osteoporosis, constitute a major issue for modern societies as a consequence of their progressive ageing. Even though these pathologies can be currently treated in the clinic, some of those treatments present drawbacks that may lead to severe complications. For instance, chemotherapy lacks great tumor tissue selectivity, affecting healthy and diseased tissues. In addition, the inappropriate use of antimicrobials is leading to the appearance of drug-resistant bacteria and persistent biofilms, rendering current antibiotics useless. Furthermore, current antiosteoporotic treatments present many side effects as a consequence of their poor bioavailability and the need to use higher doses. In view of the existing evidence, the encapsulation and selective delivery to the diseased tissues of the different therapeutic compounds seem highly convenient. In this sense, silica-based mesoporous nanoparticles offer great loading capacity within their pores, the possibility of modifying the surface to target the particles to the malignant areas and great biocompatibility. This manuscript is intended to be a comprehensive review of the available literature on complex bone diseases treated with silica-based mesoporous nanoparticles—the further development of which and eventual translation into the clinic could bring significant benefits for our future society.

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pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

Cited by 62 publications

References 206 publications

Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery

Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery

Early pH Changes in Musculoskeletal Tissues upon Injury—Aerobic Catabolic Pathway Activity Linked to Inter-Individual Differences in Local pH

Mesoporous Silica Nanoparticles for the Treatment of Complex Bone Diseases: Bone Cancer, Bone Infection and Osteoporosis

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