Chitosan-based nanocomposites for the repair of bone defects

Keller, Laetitia; Regiel-Futyra, Anna; Gimeno, Marina; Eap, Sandy; Mendoza, Gracia; Andreu, Vanesa; Wagner, Quentin; Kyzioł, Agnieszka; Sebastián, Víctor; Stochel, Grażyna; Arruebo, Manuel; Benkirane‐Jessel, Nadia

doi:10.1016/j.nano.2017.06.007

Cited by 45 publications

(20 citation statements)

References 46 publications

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“…In one study, CS/chondroitin/nano-bioglass-based polyelectrolyte composite material was developed with improved bioactivity, such as accumulation of apatite and increased expression of type-1 collagen by MG63 osteoblast-like cells in vitro and with osteointegration of the scaffold in vivo [67]. CS possesses active biomineralization properties and these could be further increased by introducing other polymers such as fucoidan [17,68] and bioglass [69].…”

Section: Bonementioning

confidence: 99%

Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine

et al. 2019

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Over the last few decades, chitosan has become a good candidate for tissue engineering applications. Derived from chitin, chitosan is a unique natural polysaccharide with outstanding properties in line with excellent biodegradability, biocompatibility, and antimicrobial activity. Due to the presence of free amine groups in its backbone chain, chitosan could be further chemically modified to possess additional functional properties useful for the development of different biomaterials in regenerative medicine. In the current review, we will highlight the progress made in the development of chitosan-containing bioscaffolds, such as gels, sponges, films, and fibers, and their possible applications in tissue repair and regeneration, as well as the use of chitosan as a component for drug delivery applications.

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Section: Bonementioning

confidence: 99%

Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine

et al. 2019

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“…In many applications, silica has been combined with MMT, since it provides better dispersion and exfoliation in MMT nanocomposites. [72,158,166] Other hybrids combine [175] silica and CS for fuel cells, [164] biomaterial for bone regeneration, [167,168] among others. More examples are shown in Table 13.…”

Section: Nano-oxidesmentioning

confidence: 99%

An application‐oriented roadmap to select polymeric nanocomposites for advanced applications: A review

2019

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Polymeric nanocomposites are the materials incorporating nanosized inclusions into the polymer matrixes. The result of the addition of nanoparticles/fibers is a drastic improvement in properties that may include mechanical, electrical, thermal conductivity, or even the acoustical properties. Polymer nanocomposites have spawned huge interest for the development of high‐performance products such as lightweight sensors, thin‐film capacitors, batteries, flame retardant products, biodegradable and biocompatible materials, and so on. The field of polymer nanocomposites has been at the forefront of research in the polymer community for the past few decades and an extremely large number of scientific papers have been published. Nevertheless, application‐oriented guidelines for selecting the ecofriendly nanocomposites for advanced industrial applications are missing in the state of the art. This review article summarizes the current state‐of‐the‐art polymeric nanocomposites, highlighting prominent nanofillers categorized based on their applications, origins, dimensional characteristics, and so on. Each filler type contains a short description of its main feature together with the most relevant and potential applications. To address the global concern about nondegradable wastes, novel green alternatives of each nanofiller type are discussed. Special attention is also given to the biocompatibility properties of the composites. This study provides a state‐of‐the‐art road map to select multifunctional polymeric nanocomposites from huge varieties for advanced industrial applications.

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“…Bone diseases are one of the most common body injuries, and are associated with high health expenses exceeding billions of dollars annually [ 84 ]. Prevalence of such defects is increasing; thereby, they are considered an epidemic health challenge [ 85 ]. The bone benefits from the ability to repair itself throughout the life.…”

Section: Introductionmentioning

confidence: 99%

Mesenchymal stem cells: amazing remedies for bone and cartilage defects

et al. 2020

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Skeletal disorders are among the leading debilitating factors affecting millions of people worldwide. The use of stem cells for tissue repair has raised many promises in various medical fields, including skeletal disorders. Mesenchymal stem cells (MSCs) are multipotent stromal cells with mesodermal and neural crest origin. These cells are one of the most attractive candidates in regenerative medicine, and their use could be helpful in repairing and regeneration of skeletal disorders through several mechanisms including homing, angiogenesis, differentiation, and response to inflammatory condition. The most widely studied sources of MSCs are bone marrow (BM), adipose tissue, muscle, umbilical cord (UC), umbilical cord blood (UCB), placenta (PL), Wharton’s jelly (WJ), and amniotic fluid. These cells are capable of differentiating into osteoblasts, chondrocytes, adipocytes, and myocytes in vitro. MSCs obtained from various sources have diverse capabilities of secreting many different cytokines, growth factors, and chemokines. It is believed that the salutary effects of MSCs from different sources are not alike in terms of repairing or reformation of injured skeletal tissues. Accordingly, differential identification of MSCs’ secretome enables us to make optimal choices in skeletal disorders considering various sources. This review discusses and compares the therapeutic abilities of MSCs from different sources for bone and cartilage diseases.

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Chitosan-based nanocomposites for the repair of bone defects

Cited by 45 publications

References 46 publications

Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine

Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine

An application‐oriented roadmap to select polymeric nanocomposites for advanced applications: A review

Mesenchymal stem cells: amazing remedies for bone and cartilage defects

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