Chitosan‐Based Drug Delivery Systems

Peptu, Cristian; Humelnicu, Andra Cristina; Rotaru, Razvan; Fortună, Maria Emiliana; Patraș, Xenia; Teodorescu, Mirela; Tamba, Bogdan Ionel; Harabagiu, Valeria

doi:10.1002/9781119450467.ch11

Cited by 4 publications

(6 citation statements)

References 210 publications

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“…The treatment of superficial candidiasis involves the development of mucoadhesive pharmaceutical systems for the local administration of antifungal agents. The polysaccharide-based therapeutic systems are known for achieving specific functions in a complex biological environment, since they are considered one of the most propitious subjects lying on the frontier between chemistry, biology, medicine, and bioengineering [6]. Undoubtedly, natural polymers are promptly recognized and embraced by the human body considering their biochemical similarity with extracellular matrix components [7].…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Based Therapeutic Systems for Superficial Candidiasis Treatment. Synergetic Activity of Nystatin and Propolis

Humelnicu¹,

Samoilă²,

Cojocaru³

et al. 2022

Polymers

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The paper deals with new approaches to chitosan (CS)-based antifungal therapeutic formulations designed to fulfill the requirements of specific applications. Gel-like formulations were prepared by mixing CS dissolved in aqueous lactic acid (LA) solution with nystatin (NYS) powder and/or propolis (PRO) aqueous solution dispersed in glycerin, followed by water evaporation to yield flexible mesoporous (pore widths of 2–4 nm) films of high specific surfaces between 1 × 103 and 1.7 × 103 m2/g. Morphological evaluation of the antifungal films showed uniform dispersion and downsizing of NYS crystallites (with initial sizes up to 50 μm). Their mechanical properties were found to be close to those of soft tissues (Young’s modulus values between 0.044–0.025 MPa). The films presented hydration capacities in physiological condition depending on their composition, i.e., higher for NYS-charged (628%), as compared with PRO loaded films (118–129%). All NYS charged films presented a quick release for the first 10 min followed by a progressive increase of the release efficiency at 48.6%, for the samples containing NYS alone and decreasing values with increasing amount of PRO to 45.9% and 42.8% after 5 h. By in vitro analysis, the hydrogels with acidic pH values around 3.8 were proven to be active against Candida albicans and Candida glabrata species. The time-killing assay performed during 24 h on Candida albicans in synthetic vagina-simulative medium showed that the hydrogel formulations containing both NYS and PRO presented the faster slowing down of the fungal growth, from colony-forming unit (CFU)/mL of 1.24 × 107 to CFU/mL < 10 (starting from the first 6 h).

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Section: Introductionmentioning

confidence: 99%

Chitosan-Based Therapeutic Systems for Superficial Candidiasis Treatment. Synergetic Activity of Nystatin and Propolis

Humelnicu¹,

Samoilă²,

Cojocaru³

et al. 2022

Polymers

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“…Although chitin is insoluble in most organic solvents, CS is soluble in dilute acidic solutions with pH < 6 due to the presence of primary amino groups (with pKa = 6.3) which become protonated. An increase in pH above 6, leads to the deprotonation of amino groups and CS loses its soluble character [ 9 ]. Chitosan represents a natural polymer with outstanding properties such as bioadhesivity, biocompatibility, biodegradability, non-toxicity, bioavailability, etc., which justify its attractiveness, especially for bio-related applications [ 2 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…An increase in pH above 6, leads to the deprotonation of amino groups and CS loses its soluble character [ 9 ]. Chitosan represents a natural polymer with outstanding properties such as bioadhesivity, biocompatibility, biodegradability, non-toxicity, bioavailability, etc., which justify its attractiveness, especially for bio-related applications [ 2 , 9 ]. Moreover, CS shows important biological activity, including antiviral, antifungal, and antibacterial properties; antihyperglycemic, hypocholesterolemic, and antitumoral effects; genetic material transfection; and wound healing promotion [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Chitosan Grafted Poly (Ethylene Glycol) Methyl Ether Acrylate Particulate Hydrogels for Drug Delivery Applications

Savin

Delaite

Tiron

et al. 2022

Gels

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Chitosan (CS) crosslinking has been thoroughly investigated, but the chemical reactions leading to submicronic hydrogel formulations pose problems due to various physical/chemical interactions that limit chitosan processability. The current study employs the chemical modification of chitosan by Michael addition of poly (ethylene glycol) methyl ether acrylate (PEGA) to the amine groups to further prepare chitosan particulate hydrogels (CPH). Thus, modified CS is subjected to a double crosslinking, ionic and covalent, in water/oil emulsion. The studied process parameters are polymer concentration, stirring speed, and quantity of ionic crosslinker. The CPH were structurally and morphologically characterized through infrared spectroscopy, scanning electron microscopy, light scattering granulometry, and zeta potential, showing that modified CS allows better control of dimensional properties and morphology as compared with neat CS. Swelling properties were studied in acidic and neutral pH conditions, showing that pH-dependent behavior was maintained after grafting and double crosslinking. The applicability of the prepared materials was further tested for drug loading and in vitro delivery of levofloxacin (LEV), showing excellent capacity. CPH were found to be cyto- and hemocompatible demonstrating their potential for effective use as a controlled release system for different biomedical applications.

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“…[ 31 ]. In particular, the chitosan, a natural polymer derived from chitin, causes an increase in the permeability of the epithelial membrane that favors the permanence of the drug at the absorption site and its paracellular transport [ 32 , 33 , 34 ]. Specifically, in this work, CsA, after being covalently linked with the carboxylated chitosan, was dispersed inside a polymeric matrix based on chitosan which was subsequently subjected to contact with the target site, facilitating the dispersion of the drug thanks to a high permeability and flow.…”

Section: Introductionmentioning

confidence: 99%

Chitosan Membranes Filled with Cyclosporine A as Possible Devices for Local Administration of Drugs in the Treatment of Breast Cancer

et al. 2021

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The aim of this work is the design, preparation and characterization of membranes based on cyclosporine A (CsA) and chitosan carboxylate (CC) to be used as an implantable subcutaneous medical device for a prolonged therapeutic effect in the treatment of breast cancer. The choice to use CsA is due to literature data that have demonstrated its possible antitumor activity on different types of neoplastic cells. To this end, CsA was bound to CC through an amidation reaction to obtain a prodrug to be dispersed in a chitosan-based polymeric membrane. The reaction intermediates and the final product were characterized by Fourier transform infrared spectroscopy (FT-IR) and proton nuclear magnetic resonance (1H-NMR). Membranes were analyzed by differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). The data obtained showed the effective formation of the amide bond between CsA and CC and the complete dispersion of CsA inside the polymeric membrane. Furthermore, preliminary tests, conducted on MDA-MB-231, a type of breast cancer cell line, have shown a high reduction in the proliferation of cancer cells. These results indicate the possibility of using the obtained membranes as an interesting strategy for the release of cyclosporin-A in breast cancer patients.

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Chitosan‐Based Drug Delivery Systems

Cited by 4 publications

References 210 publications

Chitosan-Based Therapeutic Systems for Superficial Candidiasis Treatment. Synergetic Activity of Nystatin and Propolis

Chitosan-Based Therapeutic Systems for Superficial Candidiasis Treatment. Synergetic Activity of Nystatin and Propolis

Chitosan Grafted Poly (Ethylene Glycol) Methyl Ether Acrylate Particulate Hydrogels for Drug Delivery Applications

Chitosan Membranes Filled with Cyclosporine A as Possible Devices for Local Administration of Drugs in the Treatment of Breast Cancer

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