Uniformly dispersed iron oxide–cellulose ferromagnetic nanocomposites were successfully obtained by ultrasonication, as a clean and energy-saving method.
The paper focuses on the advances in the field of pain treatment by transdermal delivery of specific drugs. Starting from a short description of the skin barrier, the pharmacodynamics and pharmacokinetics including absorption, distribution, action mechanism, metabolism and toxicity, aspects related to the use of pain therapy drugs are further discussed. Most recent results on topical anesthetic agents as well as the methods proved to overcome the skin barrier and to provide efficient delivery of the drug are also discussed. The present review is proposing to summarize the recent literature on the pharmacotherapeutic principles of local anesthetics and non-steroidal anti-inflammatory drugs, generally used to alleviate pain but also the drugs as nanoformulations with potential applications in transdermal delivery. A special attention is given to efficient formulations meant for transdermal penetration enhancement of anesthetics where the drug is encapsulated into macrocyclic molecules (cyclodextrins, cyclodextrin derivatives), liposomes or polymer nanoparticles and hydrogels.
Barium titanate submicronic particles were prepared, for the first time, by a solidstate reaction route, where the classical ball grinding/mixing and drying steps were replaced by ultrasonication and microwave assisted processes, respectively, resulting in significant reduction in both drying duration and temperature of the thermal treatment. The structure of the prepared samples was analyzed by Fourier transform infrared spectroscopy and X-ray powder diffraction, while the morphology and particle size were followed by means of scanning electron microscopy and dynamic light scattering. Dielectric properties were evaluated in the frequency range of 10 6 -10 À2 Hz. The obtained results showed that the employed synthesis process leads to well-defined tetragonal phase BaTiO 3 particles with relatively high tetragonality and average particle diameter of around 500 nm. The study on the dielectric behavior reveals that the obtained materials are appropriate for applications as passive electronic elements. The goal of the paper is to demonstrate the effectiveness of the ultrasonic treatment in the preparation of well-defined perovskite-like BaTiO 3 particles by a solid-state process.
K E Y W O R D Sbarium titanate, solid-state reaction, ultrasonication
Polymer films with high refractive index are suitable for a wide range of applications, such as optical fibers, lens and other components for optoelectronic devices. In this work, polyvinyl alcohol films were prepared from aqueous solutions, which were homogenized by ultrasonication. In order to increase the refractive index, the polymer was reinforced with barium titanate nanoparticles, which are previously ultrasonicated for an adequate dispersion inside the host polymer. The dispersion of the refractive index in visible domain was analyzed as a function of filler percent introduced in polymer, showing that an increase in sample s polarizability determined an increase in the refractive index values. The reinforcement caused a decrease of Abbe number indicating a higher light dispersion in the samples. Optical dispersion parameters were extracted from dispersion curves, revealing a reduction of band gap from 3.448 eV for pure polymer to 2.605 eV for the sample containing 2% barium titanate. Doping with the ceramic nanofiller determined a increase in optical conductivity and real part of dielectric constant as a result of appearance of new level states in the band gap. The increase of third order nonlinear optical susceptibility and nonlinear refractive index indicates the suitability of the analyzed nanocomposites for nonlinear optics applications.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.