Chitosan-based drug delivery systems

Bernkop‐Schnürch, Andreas; Dünnhaupt, Sarah

doi:10.1016/j.ejpb.2012.04.007

Cited by 793 publications

(431 citation statements)

References 72 publications

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“…In order to overcome this solubility-problem, chitin is generally converted into the more soluble chitosan (its N-deacetylated form), which can be dissolved into weak acid environments. The enhanced solubility of chitosan allows its use in several technological fields, such as in membranes for water softening processes [52], in water treatments as adsorbing material (alone or grafted to selected nanometric substrates) [53][54][55][56], in the agriculture industry as a protective agent against oxidation [57], as a bioplastic for food packaging [58,59], in the cosmetic industry as a moisturizing/conditioning agent [50], as carbon precursors for the development of cathodes in Li-S batteries [60], and in biomedicine as a drug delivery system and/or as hydrogels [61][62][63], as an antimicrobial agent/coating [34,64,65], and as technical anti-allergic textiles/sutures [66,67].…”

Section: The Chitin Industry Case Studymentioning

confidence: 99%

Aquatic-Derived Biomaterials for a Sustainable Future: A European Opportunity

Nisticò

2017

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Abstract:The valorization of aquatic-derived biowastes as possible feedstock for the production of value-added chemicals and materials is proposed here as a sustainable alternative compared to the exploitation of the more conventional (fossil) resources. In this context, the comprehension of the opportunity related to the valorization of the shellfish industry biowaste for the production of useful materials, especially focusing on chitin and its derived byproducts, is investigated. The large amount of waste produced each year by the shellfish processing industry seems to be an appealing opportunity for the European market to produce valuable products from underutilized waste. In order to highlight this important market-opportunity, the actual European situation concerning the shellfish volume of production is presented. The industrial processes necessary for the recovery of chitin, chitosan, and their derivatives are largely described, together with a wide description of their peculiar (and interesting) physicochemical properties. Even if nowadays the scientific literature suggests that this class of biopolymers is very appealing, further research is still necessary for overcoming some criticisms still present in the extraction and valorization of such substrates. However, the principles of both circular economy and green chemistry encourage the reduction of such biowastes and their exploitation as an alternative resource for a global sustainable future.

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Section: The Chitin Industry Case Studymentioning

confidence: 99%

Aquatic-Derived Biomaterials for a Sustainable Future: A European Opportunity

Nisticò

2017

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“…The gel strength is also a rate-limiting step for the sustaining of drug (Soni et al, 2016). The gel strength can be increased by increasing the viscosity and this is achieved by the changing in the grades, addition with some another polymer or change in the concentration (Bernkop-Schnürch et al, 2012;Garg et al, 2008;Boldhane et al, 2010). Selection of HPMC and HMWCH is based on the previously reported work by one of the authors of this study (Soni et al, 2016;Verma et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Crushed Puffed Rice-HPMC-Chitosan based Single-Unit Hydro-dynamically Balanced System for the Sustained Stomach Specific Delivery of Metoprolol Succinate

2017

J App Pharm Sci

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Purpose: Developed and evaluated a Hydrodynamically Balanced System (HBS) capsule system using natural and novel biodegradable polymer used as Crushed Puffed Rice (CPR) alone and in combination with auxiliary polymers (High Molecular Weight Chitosan; HMWCH and Hydroxypropyl methylcellulose; HPMC K15) for stomach specific delivery.Method: A total of nine formulations was prepared by manual shaking method and filled in colorless hard capsule shell size 1. The prepared capsule was evaluated for parameters such as drug content, in vitro buoyancy and drug release in 0.1M HCl, drug delivery kinetics.Results: Average floating time for the formulation is 08 hours. CPR is used as a buoyancy imparting agent due to its floating behavior; it floats in 0.1 M HCl (pH 1.2) and remained unwetted for the time period of 05 hours. CPR, HPMC K15, and HMWCH have a significant effect (p < 0.05) on MS retarding. Formulation D1-D9 follows zero order model and Fickian diffusion which was confirmed by R 2 value and Akaike Information Criteria (AIC). Conclusion:The data obtained from the study suggests that CPR in combination with HMWCH or HPMC K15 or HPMC K15 + HMWCH has sufficient potential to be used as a carrier for stomach specific drug delivery.

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“…Chitosan is a cationic copolymer of β-(1-4)-linked 2-acetamido-2-deoxy-d-glucopyranase and 1-amino-2-deoxy-d-glucopyranase. Due to its physicochemical characteristics, namely permeation enhancing properties, chitosan is an adequate material for drug delivery ocular devices [29]; however, it has very low mechanical integrity and enzymatically degrades, e.g, by the action of lysozyme [30].…”

Section: Introductionmentioning

confidence: 99%