Introduction:
Hydrodynamically balanced system (HBS) possesses prolonged and continuous
delivery of the drug to the gastrointestinal tract which improves the rate and extent of
medications that have narrow absorption window. The objective of this work was to develop
Hydrodynamically Balanced System (HBS) of Metoprolol Succinate (MS) as a model drug for
sustained stomach specific.
Materials and Methods:
Experimental batches were designed according to 3(2) Taguchi factorial
design. Total 9 batches were prepared of batch size 100 capsule each. Formulations were
prepared by physically blending of MS with polymers followed by encapsulation into hard
gelatin capsule shell of size 0. Polymers used were Low Molecular Weight Chitosan (LMWCH),
Crushed Puffed Rice (CPR) and Hydroxypropyl Methylcellulose K15 M (HPMC K15M). Two
factors used were buoyancy time (Y1) and time taken for 60% drug release (T60%; Y2).
Results:
The drug excipient interaction studies were performed by thermal analysis method
which depicts that there is no any drug excipient interaction occurs. In vitro buoyancy studies
and drug release studies reveals that the efficacy of HBS to remain gastro retentive for prolonged
period and concurrently sustained the release of MS in highly acidic medium. All formulations
followed zero order kinetics.
Conclusion:
Developed HBS of MS with hydrogel forming polymers could be an ideal delivery
system for sustained stomach specific delivery and would be useful for the cardiac patients
where the prolonged therapeutic action is required.