Chitosan-based biocatalytic nanoparticles for pollutant removal from wastewater

Alarcón-Payán, Dulce A.; Koyani, Rina D.; Vázquez-Duhalt, Rafael

doi:10.1016/j.enzmictec.2017.02.008

Cited by 29 publications

(15 citation statements)

References 65 publications

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“…In modern medicine, the application of nanostructures in different forms has been proposed: nanoparticles as biomarkers for imaging [ 2 ], magnetic hyperthermia [ 3 ], arrays as drug delivery systems [ 4 ], charged magnetic particles proposed as targeted therapy, and drug release as is the case in this study. The development of modern technology for its practical application and performance requires intelligent materials to innovate and lead different challenges such as biophysics [ 5 ], aerospace [ 6 ], biotechnology [ 7 ], biomedicine [ 8 ], among other current challenges [ 9 , 10 ], versatile materials that represent a challenge for nanoscience and nanotechnology. Among the smart materials, CS can be highlighted, widely known, and applied in biomedicine due to its biocompatibility, biodegradability, and adhesiveness, among other favorable properties.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of a Fe3O4@PNIPAM-Chitosan Nanocomposite and Its Potential Application in Vincristine Delivery

et al. 2021

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In this research, we conducted a systematic evaluation of the synthesis parameters of a multi-responsive core-shell nanocomposite (Fe3O4 nanoparticles coated by poly(N-isopropylacrylamide) (PNIPAM) in the presence of chitosan (CS) (Fe3O4@PNIPAM-CS). Scanning electron microscopy (SEM) was used to follow the size and morphology of the nanocomposite. The functionalization and the coating of Fe3O4 nanoparticles (Nps) were evaluated by the ζ-potential evolution and Fourier Transform infrared spectroscopy (FTIR). The nanocomposite exhibited a collapsed structure when the temperature was driven above the lower critical solution temperature (LCST), determined by dynamic light scattering (DLS). The LCST was successfully shifted from 33 to 39 °C, which opens the possibility of using it in physiological systems. A magnetometry test was performed to confirm the superparamagnetic behavior at room temperature. The obtained systems allow the possibility to control specific properties, such as particle size and morphology. Finally, we performed vincristine sulfate loading and release tests. Mathematical analysis reveals a two-stage structural-relaxation release model beyond the LCST. In contrast, a temperature of 25 °C promotes the diffusional release model. As a result, a more in-depth comprehension of the release kinetics was achieved. The synthesis and study of a magnetic core-shell nanoplatform offer a smart material as an alternative targeted release therapy due to its thermomagnetic properties.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of a Fe3O4@PNIPAM-Chitosan Nanocomposite and Its Potential Application in Vincristine Delivery

et al. 2021

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“…This process depends on the use of complexation between positively charged chitosan and negatively charged TPP by electrostatic forces [ 70 ]. Neither harmful chemicals nor critical operations are required in this process and it is very simple and mild [ 70 ]; thus, this method is one of the most common methods described for the formation of chitosomes in the literature [ 43 , 71 , 72 , 73 ].…”

Section: Resultsmentioning

confidence: 99%

Investigation of the Potential of Nebivolol Hydrochloride-Loaded Chitosomal Systems for Tissue Regeneration: In Vitro Characterization and In Vivo Assessment

et al. 2021

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In this study, we evaluated the synergistic effect of nebivolol hydrochloride (NVH), a third-generation beta-blocker and NO donor drug, and chitosan on the tissue regeneration. Ionic gelation method was selected for the preparation of NVH-loaded chitosomes using chitosan lactate and sodium tripolyphosphate. The effect of different formulation variables was studied using a full factorial design, and NVH entrapment efficiency percentages and particle size were selected as the responses. The chosen system demonstrated high entrapment efficiency (73.68 ± 3.61%), small particle size (404.05 ± 11.2 nm), and good zeta potential value (35.6 ± 0.25 mV). The best-achieved formula demonstrated spherical morphology in transmission electron microscopy and amorphization of the crystalline drug in differential scanning calorimetry and X-ray diffraction. Cell culture studies revealed a significantly higher proliferation of the fibroblasts in comparison with the drug suspensions and the blank formula. An in vivo study was conducted to compare the efficacy of the proposed formula on wound healing. The histopathological examination showed the superiority of NVH-loaded chitosomes on the wound proliferation and the non-significant difference in the collagen deposition after 15 days of the injury to that of intact skin. In conclusion, NVH-loaded chitosomes exhibited promising results in enhancing skin healing and tissue regeneration.

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“…Halogenated organics, like 2,4,6-trichlorophenol and other chlorophenols, are environmental toxic compounds. 1 They were released into the surface and ground water and soil with the development of chemical industry. 2 Due to the high toxicity and persistence in the environment, halogenated organics can cause serious harm to the environment and human health.…”

Section: Introductionmentioning

confidence: 99%

“…I G U R E 4 SEM (a,b) and confocal (c) images for DHP&Zn-CP(1,638,1,460),(1,645,1,460),(1,645,1,510), and (1,645, 1,541) can be identified from the asynchronous map. The Noda's rules confirm that the unordered structure (1,460 and 1,541 cm −1 ) exchanges before the α-helix (1,645 cm −1 ) and β-sheet (1,638 cm −1 ) structures.The TYR residue (1,510 cm −1 ) exhibited a faster H-D exchange than the α-helix (1,645 cm −1 ).…”

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A peroxidase coordinating to Zn (II) preventing heme bleaching and resistant to the interference of H₂O₂

Jiang

Feng

2020

Biotechnology Progress

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Dehaloperoxidase (DHP) catalyzes detoxifying halophenols. It is a heme-containing enzyme using H 2 O 2 as the oxidant. Heme bleaching from the active site is of great concern. In addition, the interference of DHP by H 2 O 2 leads to the inactivation of the enzyme. To solve these two problems, DHP is coordinated to Zn (II) in PBS buffer to form a biomineralized composite (DHP&Zn-CP). DHP&Zn-CP was characterized by measuring SEM and confocal images, as well as energy dispersive X-ray spectrometry mapping. Fluorescence spectra demonstrated that DHP&Zn-CP can prevent heme bleaching. Two-dimensional FTIR spectra were measured, dynamically providing insight into the structural change of DHP along the coordination process. Raman spectra were performed to analyze the structural change. The optical spectra confirmed that the forming of DHP&Zn-CP had a little effect on the structures of DHP. For the dehalogenation of 2,4,6-trichlorophenol, DHP&Zn-CP can tolerate the presence of H 2 O 2 and is resistant to the interference by H 2 O 2. The catalytic efficiency of DHP&Zn-CP is much higher than that of free DHP.

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Chitosan-based biocatalytic nanoparticles for pollutant removal from wastewater

Cited by 29 publications

References 65 publications

Synthesis and Characterization of a Fe3O4@PNIPAM-Chitosan Nanocomposite and Its Potential Application in Vincristine Delivery

Synthesis and Characterization of a Fe3O4@PNIPAM-Chitosan Nanocomposite and Its Potential Application in Vincristine Delivery

Investigation of the Potential of Nebivolol Hydrochloride-Loaded Chitosomal Systems for Tissue Regeneration: In Vitro Characterization and In Vivo Assessment

A peroxidase coordinating to Zn (II) preventing heme bleaching and resistant to the interference of H₂O₂

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Chitosan-based biocatalytic nanoparticles for pollutant removal from wastewater

Cited by 29 publications

References 65 publications

Synthesis and Characterization of a Fe3O4@PNIPAM-Chitosan Nanocomposite and Its Potential Application in Vincristine Delivery

Synthesis and Characterization of a Fe3O4@PNIPAM-Chitosan Nanocomposite and Its Potential Application in Vincristine Delivery

Investigation of the Potential of Nebivolol Hydrochloride-Loaded Chitosomal Systems for Tissue Regeneration: In Vitro Characterization and In Vivo Assessment

A peroxidase coordinating to Zn (II) preventing heme bleaching and resistant to the interference of H2O2

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Product

Resources

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A peroxidase coordinating to Zn (II) preventing heme bleaching and resistant to the interference of H₂O₂