Chitosan-based advanced materials for docetaxel and paclitaxel delivery: Recent advances and future directions in cancer theranostics

Abstract

Paclitaxel (PTX) and docetaxel (DTX) are key members of taxenes with high anti-tumor activity against various cancer cells. These chemotherapeutic agents suffer from a number of drawbacks and it seems that low solubility in water is the most important one. Although much effort has been made in improving the bioavailability of PTX and DTX, the low bioavailability and minimal accumulation at tumor sites are still the challenges faced in PTX and DTX therapy.As a consequence, biomaterial-synthesized NPs have attracted much attention due to unique properties. Among them, chitosan (CS) is of interest due to its great biocompatibility. CS is a positively charged polysaccharide with the capability of interaction with negatively charged biomolecules. Besides, it can be processed into the sheet, micro/nano-particles, scaffold, and is dissolvable in mildly acidic pH similar to the pH of the tumor microenvironment. Keeping in mind the different applications of CS in the preparation of nanocarriers for delivery of PTX and DTX, in the present review, we demonstrate that how CS functionalized-nanocarriers and CS modification can be beneficial in enhancing the bioavailability of PTX and DTX, targeted delivery at tumor site, image-guided delivery and co-delivery with other anti-tumor drugs or genes.

Optimization of Chitosan–Alginate Microparticles for Delivery of Mangostins to the Colon Area Using Box–Behnken Experimental Design

“…Chitosan with amino groups is soluble at low pH and insoluble at high pH. It also has good biocompatibility, biodegradability, and nontoxicity, and it can be readily modified for delivering drugs and bioactive compounds [17][18][19][20][21][22]. Owing to these properties, chitosan is widely used in colon-targeted drug delivery formulations.…”

Biomaterial-based strategies for maxillofacial tumour therapy and bone defect regeneration

“…Interestingly, in addition to PLGA, other components, including PVA and PEG, led to a negatively charged surface, which bypassed the disruption of the reticuloendothelial system, thus increasing the antitumour efficacy. Based on the fact that chitosan (CS)-based materials are promising carriers for drug delivery 48,49 , especially due to the improvement in water solubility, Ilaria Cacciotti et al 50 51 was used to deliver lipid-coated CDDP nanoparticles (LCC-NPs) via the transdermal route to treat oral squamous cancer, and the apoptotic index (58.6%) of cancer cells, as well as the low systemic toxicity (including nephrotoxicity, pulmonary toxicity, and hepatotoxicity), confirmed the efficiency and safety of this anticancer treatment. In addition, as three-dimensional water-rich materials, hydrogels have an excellent drug loading capacity and biocompatibility and are ideal tools for improving anticancer drug control and release kinetics [52][53][54] .…”

Multifunctional Polymeric Nanoplatforms for Brain Diseases Diagnosis, Therapy and Theranostics

“…Completed correction of the memory defect in an experimental model of AD [139] PLGA functionalized with OX26-type monoclonal antibody TMZ Cytotoxicity improvement of TMZ [140] PLGA-b-PEG-ascorbic acid Galantamine (GLM) High biodistribution, therapeutic, and sustained action of the drug [141] [44,[163][164][165][166][167][168][169][170][171][172]. Among them, polyesters have great potential because of their biocompatibility and biodegradability.…”

“…Synthetic polymers have been widely used for the delivery of bioactive agents and drugs [44,[163][164][165][166][167][168][169][170][171][172]. Among them, polyesters have great potential because of their biocompatibility and biodegradability.…”