Chitosan and polyethylene glycol based membranes with antibacterial properties for tissue regeneration

Pereira, Inês C.; Duarte, Ana Sofia; Neto, Ana S.; Ferreira, José Maria F.

doi:10.1016/j.msec.2018.11.029

Cited by 39 publications

(20 citation statements)

References 62 publications

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“…Antimicrobial polymers are also used for preventing microbial contamination and infection. These include polymers such as bacteriostatic poly(ethylene glycol) (PEG) that prevents colonization of bacteria and polymer/biopolymers that have been designed with direct killing mechanisms . There have been several promising candidates for use in the medical field that have been identified, including polymorbornenes, polymethacrylates, poly‐β‐Lactams, polymaleimides, and polycarbonates.…”

Section: Developments In Wound Treatmentmentioning

confidence: 99%

Antimicrobial Peptide‐Based Electrospun Fibers for Wound Healing Applications

Dart

Bhave

Kingshott

2019

Macromolecular Bioscience

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Current wound healing treatments such as bandages and gauzes predominantly rely on passively protecting the wound and do not offer properties that increase the rate of wound healing. While these strategies are strong at protecting any infection after application, they are ineffective at treating an already infected wound or assisting in tissue regeneration. Next‐generation wound healing treatments are being developed at a rapid pace and have a variety of advantages over traditional treatments. Features such as gas exchange, moisture balance, active suppression of infection, and increased cell proliferation are all central to developing the next successful wound healing dressing. Electrospinning has already been shown to have the qualities required to be a key technique of next generation polymer‐based wound healing treatments. Combined with antimicrobial peptides (AMPs), electrospun dressings can indeed become a formidable solution for the treatment of both acute and chronic wounds. The literature on combining electrospinning and AMPs is now starting to increase and this review aims to give a comprehensive overview of the current developments that combine electrospinning technology and AMPs in order to make multifunctional fibers effective against infection in wound healing.

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Section: Developments In Wound Treatmentmentioning

confidence: 99%

Antimicrobial Peptide‐Based Electrospun Fibers for Wound Healing Applications

Dart

Bhave

Kingshott

2019

Macromolecular Bioscience

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“…It is well known that co-doped CHAp scaffolds exhibited synergetic effects with enhanced antibacterial properties as well [94][95][96][97][98][99]. Therefore, the CHAp coating by a simultaneous incorporation of Ag + and Zn 2+ ions to study a cumulative effect of dopants was also synthesized using the sol-gel technique [89].…”

Section: Sol-gel Synthesis Of Cation-substituted Chap Layersmentioning

confidence: 99%

Sol–gel synthesis of calcium phosphate-based coatings – A review

Ishikawa

Kareiva²

2020

chemija

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Calcium phosphate (CP)-based biomaterials, especially nanostructured ones, show a high biocompatibility and increased biological properties. The coatings composed of stoichiometric hydroxyapatite have been extensively used to improve integration of metallic implants in the host bone. However, these coatings exhibited several drawbacks that limited their successful application. It was concluded in numerous articles that the sol–gel derived coatings can undergo cracking and delamination and are scarcely uniform. In this review article the recent advances on the sol–gel synthesis of different phosphate coatings and thin films are summarized. The attention is paid to coatings and thin films of calcium hydroxyapatite (CHAp), other phosphates, bioglasses and different composite materials. The state of the art, limitations, potentialities, open challenges, and the future scenarios for the application of CP bioceramics are highlighted in this study.

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“…Recent studies have demonstrated the advantages of using chitosan sponges (CS) to assemble a tissue‐engineering scaffold because of their biocompatibility and degradation rates 5‐7 . A study by Zhou et al showed that chitosan hydrogel is biocompatible and presents no hepatic or renal toxicity in rats 8 .…”

Section: Introductionmentioning

confidence: 99%

Urine‐derived stem cells loaded onto a chitosan‐optimized biphasic calcium‐phosphate scaffold for repairing large segmental bone defects in rabbits

et al. 2021

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The treatment of large segmental bone defects can be challenging for orthopedic surgeons. The development of bone tissue engineering technology, including the selection of seeding cells and the construction of scaffolds, provides a promising solution. In this study, we investigated osteogenic differentiation of human urine‐derived stem cells (hUSCs, a newly identified class of stem cells), and developed a novel porous hybrid scaffold using biphasic calcium phosphate (BCP) bioceramic ornamented with chitosan sponges (CS). We combined hUSCs with a CS/BCP hybrid scaffold to construct tissue‐engineered bone and evaluated whether the combination promotes bone regeneration in large segmental bone defects in rabbits. The study showed that hUSCs can differentiate into osteoblasts, and the hUSCs adhered, proliferated, and differentiated on CS/BCP hybrid scaffolds. Micro–computed tomography measurements, biomechanical detection, and histological analyses revealed that the combination of hUSCs and the CS/BCP hybrid scaffold enhanced bone regeneration more effectively compared with conventional pure BCP scaffolds, indicating that hUSCs can be used as a cell source for bone tissue engineering and that cell‐scaffold–based biomimetic bone may be a promising approach to the repair of bone defects.

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Chitosan and polyethylene glycol based membranes with antibacterial properties for tissue regeneration

Cited by 39 publications

References 62 publications

Antimicrobial Peptide‐Based Electrospun Fibers for Wound Healing Applications

Antimicrobial Peptide‐Based Electrospun Fibers for Wound Healing Applications

Sol–gel synthesis of calcium phosphate-based coatings – A review

Urine‐derived stem cells loaded onto a chitosan‐optimized biphasic calcium‐phosphate scaffold for repairing large segmental bone defects in rabbits

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