Chitosan: An undisputed bio-fabrication material for tissue engineering and bio-sensing applications

Baranwal, Anupriya; Kumar, Ashutosh; Priyadharshini, A.; Oggu, Gopi Suresh; Bhatnagar, Ira; Srivastava, Ananya; Chandra, Pranjal

doi:10.1016/j.ijbiomac.2018.01.006

Cited by 159 publications

(65 citation statements)

References 154 publications

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“…The hADSCs also showed higher focal adhesions when they were developed on GO films, alongside expanded interaction between actin. The synergistic effect of a hybrid graphene oxide–chitosan system and biomimetic mineralization on osteoblast functions . Therefore, graphene‐based materials have variety of applications in tissue engineering field.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Graphene and Graphene‐Based Materials in Biomedical Science

Swetha

Manisha

Prasad

2018

Part & Part Syst Charact

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Graphene and its composite materials are very important in many disciplines of science and have been used enormously by researchers since their discovery in 2004. These are a new group of compounds, and are also wonderful model systems for quantum behavior studies. Their properties like exceptional conductivity, biocompatibility, surface area, mechanical strength, and thermal properties make them rising stars in the scientific community. Graphene and its composite compounds are utilized widely in different medical applications, for example, biosensing of biological compounds responsible for disease development, bioimaging of various cells, tissues, microorganisms, animal models, etc. In addition, they are used for enhancing and supporting the stem cell differentiation, i.e., regenerative medicine for regeneration studies of various human organs, tissue engineering in biology for the development of carrier materials, as well as in bone reformation. This review focuses on the modification procedure involved in the fabrication of graphene‐based biomaterials for various applications and recent developments in research related to graphene and graphene‐based materials in biosensing, optical sensing, gas sensing, drug, gene, protein delivery, tissue engineering, and bioimaging. In addition, the potential toxicological effects of graphene‐based biomaterials are discussed.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Graphene and Graphene‐Based Materials in Biomedical Science

Swetha

Manisha

Prasad

2018

Part & Part Syst Charact

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“…The swelling of the samples increased when the CS content was increased in the blend because of the decrease in the network density of the blends. Consequently, more free volume was accessible in the polymer network, and more water could be absorbed …”

Section: Resultsmentioning

confidence: 99%

“…Chitosan (CS), a cationic natural polymer derived from chitin, has been widely used in various fields, including drug delivery and biotechnology . This polymer possesses great biocompatibility, biodegradability, antibacterial properties, hemostatic activity, and low mechanical properties . As a hydrophilic synthetic polymer, poly(vinyl alcohol) (PVA) is used in diverse commercial and biomedical applications because of its unique chemical and physical properties.…”

Section: Introductionmentioning

confidence: 99%

Effect of electron‐beam irradiation followed by annealing on the physical properties of poly(vinyl alcohol)–chitosan blend films at different weight ratios

Jahanabadi

Sheikh²,

Mahdavi

et al. 2019

J of Applied Polymer Sci

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The aim of this study was to examine the effect of electron‐beam irradiation followed by annealing on the physical properties of poly(vinyl alcohol) (PVA)–chitosan (CS) blend films. Solution‐cast films containing various ratios of polymers were exposed to irradiation doses of 26, 39, and 52 kGy at room temperature and then annealed at 100 °C. The results show that at all doses, with an increase in the weight ratio of CS, the gel content of the samples decreased, and the water absorption of the samples increased. The irradiation dose ranged from 26 to 39 kGy; this led to an increased gel content and a decreased degree of swelling in the samples. However, at 52 kGy, an increase in the amount of swelling was observed. X‐ray diffraction analysis and scanning electronic microscopy images of the samples revealed that the increase in the irradiation dose reduced the crystallinity and increased the surface heterogeneity, respectively. The tensile strength of the blends decreased with decreasing PVA–CS weight ratio. This property of the samples increased with dose from 26 to 39 kGy and decreased at 52 kGy. The elongation at break of the samples decreased with both an increase in the irradiation dose and a decrease in the CS content. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47820.

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“…to form nanocomposites, chitosan can either act as a substrate material that will contribute the bonding sites or just function as dispersion material that makes the component material more stable and the surface coating process easier . Nanomaterial such as carbon nanotubes and graphene nanosheets are usually added into chitosan as enhancement materials . It is reported that the graphene nanosheets can improve the uniformity and evenness of chitosan thin film and promote DNA hybridization reaction.…”

Section: Recent Developmentsmentioning

confidence: 99%

Recent development in chitosan nanocomposites for surface‐based biosensor applications

Jiang

Cheng

2019

Electrophoresis

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Recent years have witnessed ever expanding use of biosensors in the fields of environmental monitoring, homeland security, pharmaceutical, food and bioprocessing, and agricultural industries. To produce effective and reliable biosensors, good quality immobilization of biological recognition elements is critical. Chitosan and its nanocomposites emerge as an excellent immobilization matrix on biosensor surface. As a natural polysaccharide, chitosan has many useful characteristics, such as high permeability and mechanical strength, biocompatibility and non‐toxicity, availability, and low cost. Due to the presence of amino and hydroxyl groups on chitosan, chitosan can easily crosslink with a variety of nanomaterials. This investigation of chitosan nanocomposite‐based biosensors presents recent development and innovations in the preparation of chitosan nanocomposites in coordination with biosensors for various bio‐detection applications, including chitosan nanocomposites formed with carbon nanomaterials, various inorganic and biological complexes. These chitosan nanocomposite based biosensors have demonstrated good sensitivity selectivity and stability for the detection of different types of targets ranging from glucose, proteins, DNAs, small biomolecules to bacteria. It is in our hope that this review will offer guidance for the development of novel biosensors and open up opportunities in the field of biosensor research.

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Chitosan: An undisputed bio-fabrication material for tissue engineering and bio-sensing applications

Cited by 159 publications

References 154 publications

Graphene and Graphene‐Based Materials in Biomedical Science

Graphene and Graphene‐Based Materials in Biomedical Science

Effect of electron‐beam irradiation followed by annealing on the physical properties of poly(vinyl alcohol)–chitosan blend films at different weight ratios

Recent development in chitosan nanocomposites for surface‐based biosensor applications

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