Chitosan: A compound for drug delivery system in gastric cancer-a review

Shafabakhsh, Rana; Yousefi, Bahman; Asemi, Zatollah; Nikfar, Banafsheh; Mansournia, Mohammad Alì; Hallajzadeh, Jamal

doi:10.1016/j.carbpol.2020.116403

Cited by 82 publications

(46 citation statements)

References 51 publications

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“…Chitin has good mechanical strength, is biocompatible, bioactive and biodegradable, but has limited utilization due to low solubility. Therefore, it is converted into chitosan by deacetylation in the presence of hydroxide at high temperatures [ 38 ]. Chitin is extracted from marine organisms such as lobsters and molluscs, and from crab shells, insects, yeast, and fungi.…”

Section: Chitosan-based Nanoparticlesmentioning

confidence: 99%

“…Protonation of the amino group in an acidic medium results in cation formation. Chitosan exhibits unique behavior because of its cationic nature [ 38 , 41 ]. Modification of chitosan and the stability of drugs delivered using chitosan decrease the adverse effects of diseases and increase the biocompatibility of drugs for various diseases [ 42 ].…”

Section: Chitosan-based Nanoparticlesmentioning

confidence: 99%

“…Complexation of chitosan with anionic charged polymers results in an interesting gelation property [ 43 ]. Methods generally applied for the preparation of chitosan nanoparticles include the microemulsion method, ionic gelation, and micro-emulsion solvent diffusion method [ 3 , 38 ]. In the microemulsion method, chitosan nanoparticles are prepared, and micellar droplets are cross-linked in the presence of glutaraldehyde.…”

Section: Chitosan-based Nanoparticlesmentioning

confidence: 99%

“…The main problem related to cancer treatment is finding a drug delivery system that fits the requirements. Shafabakhsh et al [ 38 ] reported a review of gastric cancer treatment using chitosan nanoparticles. The authors investigated the effect of the anticancer drug norcantharidin conjugated with carboxymethyl modified chitosan.…”

Section: Chitosan-based Nanoparticlesmentioning

confidence: 99%

“…In comparison with the simple drug, the carboxymethyl/chitosan encapsulated the drug successfully and suppressed the migration and proliferation of gastric cancer cells. This study reported that carboxymethyl chitosan could increase gene expression and may provide a favorable drug delivery system for gastric cancer treatments [ 38 , 63 ]. Moreover, chitosan nanoparticles used for the treatment of H. pylori infection have been shown to improve the effect of amoxicillin; chitosan nanoparticles improve the release time of the drug by preventing them from enzymatic and acidic breakdown through bonding to the mucus barrier of the stomach and drug release into the mucus barrier, thus leading to greater efficacy at the infected site [ 64 , 65 ].…”

Section: Chitosan-based Nanoparticlesmentioning

confidence: 99%

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A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

et al. 2020

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Biodegradable natural polymers have been investigated extensively as the best choice for encapsulation and delivery of drugs. The research has attracted remarkable attention in the pharmaceutical industry. The shortcomings of conventional dosage systems, along with modified and targeted drug delivery methods, are addressed by using polymers with improved bioavailability, biocompatibility, and lower toxicity. Therefore, nanomedicines are now considered to be an innovative type of medication. This review critically examines the use of natural biodegradable polymers and their drug delivery systems for local or targeted and controlled/sustained drug release against fatal diseases.

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Section: Chitosan-based Nanoparticlesmentioning

confidence: 99%

Section: Chitosan-based Nanoparticlesmentioning

confidence: 99%

Section: Chitosan-based Nanoparticlesmentioning

confidence: 99%

Section: Chitosan-based Nanoparticlesmentioning

confidence: 99%

Section: Chitosan-based Nanoparticlesmentioning

confidence: 99%

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A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

et al. 2020

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Investigation of the properties of chitosan–Pluronic based nanogel drug delivery systems utilizing various Pluronic types

Nguyen,

Nguyen

et al. 2024

Polymer Engineering & Sci

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This research aimed to create self‐assembled nanogel particles using chitosan grafted with various types of Pluronic to encapsulate curcumin, a hydrophobic biological agent. The study explored the properties of CS–Pluronic nanogels using Pluronic types L61, P123, F127, and F68, each varying in hydrophilic–lipophilic balance (HLB) index. Findings indicated that the critical micelle concentration (CMC) of Pluronics and CS–Pluronic copolymers did not depend on the HLB values but were influenced by the structural characteristics of each Pluronic type. The efficiency of curcumin encapsulation within the nanogels correlated with the CMC values of the CS–Pluronic copolymers, where lower CMC values resulted in higher encapsulation efficiencies. The curcumin‐loaded nanogels were spherical, positively charged, and had an average diameter under 200 nm. Controlled, pH‐dependent release of curcumin was observed in vitro studies conducted at 37°C in PBS at pH levels of 7.4 and 5.0, with a faster release in acidic conditions. Biocompatibility testing indicated that nanogel biocompatibility was influenced by the HLB value of Pluronic, with lower HLB values associated with reduced biocompatibility. Cytotoxicity testing revealed that curcumin‐loaded nanogels had increased cytotoxicity on MCF‐7 cells compared to free curcumin. CS–P123 emerged as the most effective carrier, meeting biocompatibility and stability requirements during storage.Highlights CS–Pluronic serves as an effective hydrophobic drug delivery system. The capacity of CS–Pluronic to encapsulate hydrophobic drugs is determined by its CMC value rather than its HLB index. CS–Pluronic is a copolymer known for its excellent biocompatibility. CS–Pluronic increases the toxicity of curcumin in nanogels compared to free curcumin.

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