Chitin and chitosan composites for bone tissue regeneration

Akpan, E. I.; Gbenebor, O. P.; Adeosun, S. O.; Cletus, Odili

doi:10.1016/b978-0-12-817966-6.00016-9

Cited by 7 publications

(5 citation statements)

References 319 publications

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“…For instance, endothelial cells preferentially bind to scaffolds with smaller pores (≤80 µm), while fibroblasts bind favorably to bigger pores (>90 µm) [ 55 ]. Nutrients and oxygen can easily diffuse through such a scaffold with large pores whereas angiogenesis and cell migration are facilitated by the pore interconnectivity [ 56 , 57 ].…”

Section: Resultsmentioning

confidence: 99%

Facile Fabrication of Transparent and Opaque Albumin Methacryloyl Gels with Highly Improved Mechanical Properties and Controlled Pore Structures

Mehwish

Lee

2022

Gels

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For porous protein scaffolds to be employed in tissue-engineered structures, the development of cost-effective, macroporous, and mechanically improved protein-based hydrogels, without compromising the original properties of native protein, is crucial. Here, we introduced a facile method of albumin methacryloyl transparent hydrogels and opaque cryogels with adjustable porosity and improved mechanical characteristics via controlling polymerization temperatures (room temperature and −80 °C). The structural, morphological, mechanical, and physical characteristics of both porous albumin methacryloyl biomaterials were investigated using FTIR, CD, SEM, XRD, compression tests, TGA, and swelling behavior. The biodegradation and biocompatibility of the various gels were also carefully examined. Albumin methacryloyl opaque cryogels outperformed their counterpart transparent hydrogels in terms of mechanical characteristics and interconnecting macropores. Both materials demonstrated high mineralization potential as well as good cell compatibility. The solvation and phase separation owing to ice crystal formation during polymerization are attributed to the transparency of hydrogels and opacity of cryogels, respectively, suggesting that two fully protein-based hydrogels could be used as visible detectors/sensors in medical devices or bone regeneration scaffolds in the future.

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Section: Resultsmentioning

confidence: 99%

Facile Fabrication of Transparent and Opaque Albumin Methacryloyl Gels with Highly Improved Mechanical Properties and Controlled Pore Structures

Mehwish

Lee

2022

Gels

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“…45,46 Any material's biocompatibility can be influenced by its size, shape, material composition, surface wettability ( protein adsorption and cell adhesion), surface roughness/texture (to improve the scaffold-tissue response and determine cell behavior), and charge. 47,48 For biocompatibility, adverse reactions should be minimal at the interface between blood and tissue. 49,50 Therefore, the chitosan scaffold's biocompatibility with tissues led to minimal cytotoxicity.…”

Section: Papermentioning

confidence: 99%

Bioceramic and polycationic biopolymer nanocomposite scaffolds for improved wound self-healing and anti-inflammatory properties: an in vitro study

2023

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“…But the resulting hydrogels present low mechanical properties. Thus, chitosan is often modified or combined with other biomaterials to improve its mechanical properties [60,61]. One example is the work of Zafeiris and co-workers, where they combined chitosan with HAp and proposed to crosslink chitosan with genipin to improve its mechanical properties [61].…”

Section: Natural Based Polymersmentioning

confidence: 99%