Chiral Recognition Methods in Analytical Chemistry: Role of the Chiral Ionic Liquids

Singh, Avtar; Kaur, Nirmaljeet; Chopra, Harish Kumar

doi:10.1080/10408347.2019.1565985

Cited by 38 publications

(18 citation statements)

References 58 publications

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“…They are useful in organic synthesis or “green” chemistry . Chiral ionic liquids may be used for asymmetric synthesis or analytical enantioseparations . Although they are natural targets for chiroptical spectroscopies, so far they have been studied relatively rarely by these techniques.…”

Section: Vibrational Circular Dichroismmentioning

confidence: 99%

Recent Trends in Chiroptical Spectroscopy: Theory and Applications of Vibrational Circular Dichroism and Raman Optical Activity

2020

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Chiroptical spectroscopy exploring the interaction of matter with polarized light provides many tools for molecular structure and interaction studies. Here, some recent discoveries are reviewed, primarily in the field of vibrational optical activity. Technological advances results in the development of more sensitive vibrational circular dichroism (VCD), Raman optical activity (ROA) or circular polarized luminescence (CPL) spectrometers. Significant contributions to the field also come from the light scattering and electronic structure theories, and their implementation in computer systems. Finally, new chiroptical phenomena have been observed, such as enhanced circular dichroism of biopolymers (protein fibrils, nucleic acids), plasmonic and resonance chirality‐transfer ROA experiments. Some of them are not yet understood or attributed to instrumental artifacts so far. Nevertheless, these unknown territories also indicate the vast potential of the chiroptical spectroscopy, and their investigation is even more challenging.

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Section: Vibrational Circular Dichroismmentioning

confidence: 99%

Recent Trends in Chiroptical Spectroscopy: Theory and Applications of Vibrational Circular Dichroism and Raman Optical Activity

2020

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Section: Classification and Application Of Ilsmentioning

confidence: 99%

“…The obvious consequence of the rapidly expanding interest in ionic liquids is the growing number of applications in which these ionic salts are being used [ 10 , 29 , 30 , 31 ], for purposes as diverse as catalysis [ 32 , 33 ], fuel cells [ 34 ], safe electrolytes [ 35 , 36 ], lubrication [ 37 , 38 ], biomass treatment [ 39 ] and energy storage [ 17 , 40 , 41 ]. In the field of analytical chemistry, ILs have gained greatest popularity in various types of extractions, separations and identification techniques, i.e., gas chromatography (GC), liquid chromatography (LC), capillary electrophoresis (CE), electrochemistry or mass spectrometry (MS) [ 24 , 26 , 42 , 43 ]. The first attempts to use ionic liquids as solvents for kinetics or electrochemistry were described by Swain in 1967 [ 44 ].…”

Section: Classification and Application Of Ilsmentioning

confidence: 99%

“…To date, only a few reviews on the synthesis and utility of chiral ionic liquids have been published. Some of them focus their attention on the synthesis of CILs [22,23], the role of CILs in chiral recognition of the enantiomers using various analytical techniques such as NMR and spectroscopy [24,25], liquid and gas chromatography [24][25][26] and capillary electrophoresis [24,26]. This review collectively describes the advantages of using CILs for enantioseparation in tandem with extraction including aqueous biphasic system (ABS) extraction systems, solid-liquid two-phase systems, liquid-liquid extraction systems with hydrophilic CILs, liquid-liquid extraction systems with hydrophobic CILs, solid-phase extraction and induced-precipitation techniques and separation techniques such as liquid chromatography and countercurrent chromatography.…”

Section: Introductionmentioning

confidence: 99%

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Chiral Ionic Liquids: Structural Diversity, Properties and Applications in Selected Separation Techniques

Flieger

Feder‐Kubis

Tatarczak-Michalewska

2020

IJMS

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Ionic liquids (ILs) are chemical compounds composed of ions with melting points below 100 °C exhibiting a design feature. ILs are commonly used as the so-called green solvents, reagents or highly efficient catalysts in varied chemical processes. The huge application potential of ionic liquids (IL) justifies the growing interest in these compounds. In the last decade, increasing attention has been devoted to the development of new methods in the synthesis of stable chiral ionic liquids (CILs) and their application in various separation techniques. The beginnings of the successful use of CILs to separate enantiomers date back to the 1990 s. Most chiral ILs are based on chiral cations or chiral anions. There is also a limited number of CILs possessing both a chiral cation and a chiral anion. Due to the high molecular diversity of both ions, of which at least one has a chiral center, we have the possibility to design a large variety of optically active structures, thus expanding the range of CIL applications. Research utilizing chiral ionic liquids only recently has become more popular. However, it is the area that still has great potential for future development. This review aimed to describe the diversity of structures, properties and examples of applications of chiral ionic liquids as new chiral solid materials and chiral components of the anisotropic environment, providing chiral recognition of enantiomeric analytes, which is useful in liquid chromatography, countercurrent chromatography and other various CIL-based extraction techniques including aqueous biphasic (ABS) extraction systems, solid–liquid two-phase systems, liquid–liquid extraction systems with hydrophilic CILs, liquid–liquid extraction systems with hydrophobic CILs, solid-phase extraction and induced-precipitation techniques developed in the recent years. The growing demand for pure enantiomers in the pharmaceutical and food industries sparks further development in the field of extraction and separation systems modified with CILs highlighting them as affordable and environmentally friendly both chiral selectors and solvents.

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“…Their paramount role has been observed in various applications including electrochemistry, catalysis, material science, analytical chemistry, biomass processing, separation sciences, pharmaceutical chemistry, etc. . The properties of ILs can be easily tuned by selecting a suitable pair of cation and anion .…”

Section: Introductionmentioning

confidence: 99%

Exploring the Potential of Supported Ionic Liquids as Building Block Systems in Catalysis

Kaur

Chopra

2020

ChemistrySelect

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Supported ionic liquid catalysts have gained significant attention in recent years to overcome the limitations of the homogeneous and heterogeneous catalysis. The thin film containing dispersed homogeneous catalyst in the ionic liquid have been immobilized onto various porous solid supports having a high surface area to synthesize supported ionic liquids (SILs) that acted as potential organocatalysts in organic green synthesis. Support materials, ionic liquids, and molecularly dispersed catalysts have played a significant role in increasing the catalytic activity of the SIL catalysts. In the present review, the literature of the last decade concerning the synthesis of SIL catalysts by using different strategies as well as their applications in organic synthesis is incorporated. The main emphasis of the present work is to critically analyze the recent developments in the supported molecular dispersed catalysts (such as lewis acids, organometallic complexes, metal nanoparticles, and chemical functionality associated with cation/ anion of ionic liquids) using ILs and explore their potential to act as building block systems in catalysis.

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Chiral Recognition Methods in Analytical Chemistry: Role of the Chiral Ionic Liquids

Cited by 38 publications

References 58 publications

Recent Trends in Chiroptical Spectroscopy: Theory and Applications of Vibrational Circular Dichroism and Raman Optical Activity

Recent Trends in Chiroptical Spectroscopy: Theory and Applications of Vibrational Circular Dichroism and Raman Optical Activity

Chiral Ionic Liquids: Structural Diversity, Properties and Applications in Selected Separation Techniques

Exploring the Potential of Supported Ionic Liquids as Building Block Systems in Catalysis

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