2020
Abstract: Chiroptical spectroscopy exploring the interaction of matter with polarized light provides many tools for molecular structure and interaction studies. Here, some recent discoveries are reviewed, primarily in the field of vibrational optical activity. Technological advances results in the development of more sensitive vibrational circular dichroism (VCD), Raman optical activity (ROA) or circular polarized luminescence (CPL) spectrometers. Significant contributions to the field also come from the light scatterin…
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Cited by 49 publications
(43 citation statements)
References 276 publications
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“…As the wavelengths associated with vibrational transitions are about ten times longer than for the electronic transitions of CD in the UV/vis range (electronic CD, ECD), typical VCD g-factors are smaller than those observed in ECD and remain on the order of 10 −4 . 18 Significantly enhancing chiroptical activity requires a breakdown of the electric dipole approximation, which indicates that g-factors that exceed the 'molecular' limit can be achieved either by decreasing the wavelength of light 19 or by exploiting larger molecules and structures. But is there evidence for this?…”
Section: ½( + )mentioning
confidence: 99%
“…By measuring the difference in intensity between the two polarization states during the ROA experiment, information regarding the molecular absolute conguration (AC) and the conformation can be obtained. [1][2][3][4][5][6][7][8] One of the main applications of ROA is the empirical determination of the structural aspects of proteins, such as their secondary structure. [6][7][8] For small organic (bio)molecules (peptides, carbohydrates, natural products) the ROA spectra have proven to be substantially more difficult to interpret solely based on empirical data.…”
Section: Introductionmentioning
confidence: 99%
“…Indeed, chirality accounts for structural and functional diversity of biological molecules, is essential for pharmacy and important in material sciences. Need for characterization of chiral substances motivated fast development of Vibrational Circular Dichroism (VCD) and Raman Optical Activity (ROA) 1,2 which have become complementary to much more sensitive Electronic Circular Dichroism (ECD). This is due to the distinctiveness and specificity of weak but abundant vibrational bands contrasting with a low number of intense but broad electronic ones.…”
Section: Introductionmentioning
confidence: 99%
“…Since its discovery, 1 spectroscopy of Raman optical activity (ROA) has developed into many forms 2 and has been applied for various systems, such as organic molecules, 3 sugars, [4][5][6] peptides, 7,8 proteins, [9][10][11] nucleic acids, and even whole viruses. [12][13][14][15] The ROA measures a small difference in the scattering of right-and left-circularly polarized light, and is therefore more sensitive to enantiomers or other variations in molecular structure than upolarized Raman scattering.…”
mentioning
confidence: 99%
“…Interaction of light with chiral molecules is a fascinating topic, discovered already in early experiments of Faraday and Pasteur, [1] followed much later by spectroscopy of vibrational circular dichroism (VCD), [2] Raman optical activity (ROA) and many other techniques. [3] Quite recently, for example, enhanced VCD was pointed out as a useful tool for studies of protein fibrils associated with neurodegenerative diseases, [4] resonance ROA spectra were found sensitive to carotenoid aggregation [5] or paramagnetic excited states of halogen gases. [6] Also "chirality transfer" phenomena when chiral molecules make non-chiral ones optically active attracted atten-tion because of multiple aspects.…”
mentioning
confidence: 99%
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