Chiral HPLC analysis of formoterol stereoisomers and thermodynamic study of their interconversion in aqueous pharmaceutical formulations

Akapo, Samuel O.; McCrea, Chithra; Gupta, June; Roach, Mark; Skinner, Wayne S.

doi:10.1016/j.jpba.2008.12.004

Cited by 22 publications

(14 citation statements)

References 18 publications

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“…However, the best chromatographic properties for the separation of ( R / S )‐warfarin and ( R / S )‐propranolol enantiomers were obtained when AGP was bonded to silica monolith. This chiral selector was also used for separation of other β‐blocker enantiomers and formoterol stereoisomers . AGP stationary phase may be also applied for drug–protein interaction measurements .…”

Section: Stationary Phases With Bonded Proteinsmentioning

confidence: 99%

Amino acids, peptides, and proteins as chemically bonded stationary phases – A review

Bocian

Skoczylas

Buszewski

2015

J of Separation Science

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The selectivity of chromatographic separation depends mostly on the stationary phase and mobile phase composition. Despite being a material with bonded simple organic molecule, a wide group of stationary phases contain immobilized compound that possesses biological activity. Stationary phases that contain amino acids and peptides as well as enzymes and proteins are alternative materials that may be used for liquid chromatographic separations and are reviewed in this work. In the case of peptide-bonded stationary phases, most of these types of materials were elaborated in the 1970s and 1980s; however, over the last few years a growing interest has been observed which is connected with hydrophilic interaction liquid chromatography. The most important application of amino acid and peptide-bonded stationary phases is connected with separation of amino acids, their derivatives, and peptides. The main advantage of such materials is the ability for chiral separations.

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Section: Stationary Phases With Bonded Proteinsmentioning

confidence: 99%

Amino acids, peptides, and proteins as chemically bonded stationary phases – A review

Bocian

Skoczylas

Buszewski

2015

J of Separation Science

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“…22,23 There is no significant inversion of the 2 individual enantiomers back to the racemate. 24 Arformoterol, the (R;R) entaniomer of formoterol was approved by the FDA in 2006 as a solution for inhalation in patients with chronic obstructive pulmonary disease (COPD). There are little pharmacokinetic data for the (R;R)-and (S;S)-enantiomers, but the area under the curve and half-life after single or 14 days of dosing are similar indicating no accumulation of the (S;S) enantiomer.…”

Section: Arformoterolmentioning

confidence: 99%

Chiral Switch Drugs for Asthma and Allergies: True Benefit or Marketing Hype

Blake

Raissy

2013

Pediatric Allergy, Immunology, and Pulmonology

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“…Literature survey reveals that several analytical methods have been published for the estimation of Formoterol Fumarate alone or in combination with other drugs. Some of these methods include HPLC [12][13][14][15] , GC 16 and UV spectrophotometry 17 . Various methods have been reported for estimation of Mometasone Furoate alone or in combination with other drugs including UV spectrophotometry 18 and supercritical fluid chromatography 19 .…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric Method for Simultaneous Estimation of Formoterol Fumarate and Mometasone Furoate in Respicaps

R¹,

Jain²

2013

Int. Res. J. Pharm.

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The present work represents a UV-Spectrophotometric method for the simultaneous estimation of Formoterol Fumarate (FF) and Mometasone Furoate (MF) in respicaps dosage form. This method is based on area under curve (AUC) in the wavelength range of 210-220nm and 242-252nm. Linearity was found in the concentration ranges of 3-18μg/ml and 6-21μg/ml, for Formoterol Fumarate and Mometasone Furoate, respectively. This method was validated as per International Conference on Harmonization (ICH) guidelines. Validation results suggest that the proposed method is simple, rapid, accurate, sensitive and precise that can be applied for routine estimation of FF and MF in bulk drug and combined dosage form

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Chiral HPLC analysis of formoterol stereoisomers and thermodynamic study of their interconversion in aqueous pharmaceutical formulations

Cited by 22 publications

References 18 publications

Amino acids, peptides, and proteins as chemically bonded stationary phases – A review

Amino acids, peptides, and proteins as chemically bonded stationary phases – A review

Chiral Switch Drugs for Asthma and Allergies: True Benefit or Marketing Hype

Spectrophotometric Method for Simultaneous Estimation of Formoterol Fumarate and Mometasone Furoate in Respicaps

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