Chiral covalent organic frameworks: design, synthesis and property

Han, Xing; Chen, Yuan; Hou, Bang; Liu, Lujia; Li, Haiyang; Tan, Chunxia; Cui, Yong

doi:10.1039/d0cs00009d

Cited by 267 publications

(157 citation statements)

References 189 publications

(244 reference statements)

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“…The structures and properties of COFs are determined by the reactive and functional groups of their building blocks, which have been discussed in detail in some other reviews [40][41][42][43]. Typically, COFs are synthesized through reactions between different functional groups, and some widely used building blocks and linkages for COFs are listed in Table 1.…”

Section: Performance Optimization Of 2d/3d Cofsmentioning

confidence: 99%

Recent Progress in Nanoscale Covalent Organic Frameworks for Cancer Diagnosis and Therapy

Yao

Liu

2021

Nano-Micro Lett.

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Covalent organic frameworks (COFs) as a type of porous and crystalline covalent organic polymer are built up from covalently linked and periodically arranged organic molecules. Their precise assembly, well-defined coordination network, and tunable porosity endow COFs with diverse characteristics such as low density, high crystallinity, porous structure, and large specific-surface area, as well as versatile functions and active sites that can be tuned at molecular and atomic level. These unique properties make them excellent candidate materials for biomedical applications, such as drug delivery, diagnostic imaging, and disease therapy. To realize these functions, the components, dimensions, and guest molecule loading into COFs have a great influence on their performance in various applications. In this review, we first introduce the influence of dimensions, building blocks, and synthetic conditions on the chemical stability, pore structure, and chemical interaction with guest molecules of COFs. Next, the applications of COFs in cancer diagnosis and therapy are summarized. Finally, some challenges for COFs in cancer therapy are noted and the problems to be solved in the future are proposed.

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Section: Performance Optimization Of 2d/3d Cofsmentioning

confidence: 99%

Recent Progress in Nanoscale Covalent Organic Frameworks for Cancer Diagnosis and Therapy

Yao

Liu

2021

Nano-Micro Lett.

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“…The ability of a chiral probe to distinguish between two enantiomers of a chiral molecule, or the so called chirality recognition, is a very important consideration for biochemistry 1 and organic chemistry. 2,3 The human body has numerous chiral receptors itself. For example, (R)-limonene smells more like lemons while (S)-limonene smells more like oranges.…”

Section: Introductionmentioning

confidence: 99%

Dispersion forces in chirality recognition – a density functional and wave function theory study of diols

Aniban

Hartwig

Wuttke

et al. 2021

Phys. Chem. Chem. Phys.

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“…Specific to the catalytic environment, Bronsted acid‐base, Lewis acid‐base, redox active sites, chiral centers, steric hindrance and adjustable channels have been all engaged to meet the needs of promoting the catalytic activity. [ 14–18 ] Furthermore, the coordination and electronic states of active sites in the periodical structure are identified by high resolution spectroscopy techniques, and the interactions with reactants are visualized by operando experiments. [ 19–23 ] The theoretical calculations further benefit from the explicit structure of MOFs, laying the guidance for optimization of the catalytic activity.…”

Section: Introductionmentioning

confidence: 99%

Engineering Nanoscale Metal‐Organic Frameworks for Heterogeneous Catalysis

et al. 2021

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Metal‐organic frameworks (MOFs) are porous crystalline materials composed of metal ions (or clusters) and organic ligands. Targeted preparation of nanoscale MOFs has been successfully achieved through numerous synthetic methods and is beneficial to improve the utilization of catalytic sites. On one hand, the dynamic bonds and rich selection of both metal centers and organic molecules enable broadening the types and functions of MOFs, thus offering the basis for rational design of heterogeneous catalysts at the molecular level. On the other hand, the reversible nature of connections between metal centers and organic ligands brings serious challenges about its stability under harsh reaction conditions. To optimize the catalytic performance of MOFs, considerable efforts have been devoted to tune the chemical environment of active sites by introducing electronic or channel confinement effect as well as controlling their size growth at nanoscale for increasing the surface coordination unsaturated sites. In this review, the state‐of‐the‐art development of nanoscale MOFs is summarized and particular focus is placed on regulation strategies of catalytic sites. The authors also propose the current challenges, the problems awaiting to be solved and opportunities in the future.

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Chiral covalent organic frameworks: design, synthesis and property

Abstract: Owing to the unique structural features and facile tunability of the subcomponents and channels, chiral COFs show great potential in heterogeneous catalysis, enantioselective separation, and recognition.

Cited by 267 publications

References 189 publications

Recent Progress in Nanoscale Covalent Organic Frameworks for Cancer Diagnosis and Therapy

Recent Progress in Nanoscale Covalent Organic Frameworks for Cancer Diagnosis and Therapy

Dispersion forces in chirality recognition – a density functional and wave function theory study of diols

Engineering Nanoscale Metal‐Organic Frameworks for Heterogeneous Catalysis

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