Recent Progress in Nanoscale Covalent Organic Frameworks for Cancer Diagnosis and Therapy

Yao, Shuncheng; Liu, Zhongfan; Li, Linlin

doi:10.1007/s40820-021-00696-2

Cited by 51 publications

(25 citation statements)

References 116 publications

(154 reference statements)

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“…Compared to conventional medicine, nanoparticle formulations usually have improved biodistribution and enhanced accumulations in tumors, thus exhibiting elevated therapeutic efficiencies with reduced side effects [2][3][4][5]. Moreover, taking advantage of their unique properties, nanoparticles can function as imaging agents for tumor tracking, remodel the tumor microenvironment, and even serve as drug-free therapeutics, providing versatile platforms for cancer diagnosis and therapy [6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Nanozymes: Versatile Platforms for Cancer Diagnosis and Therapy

2022

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Natural enzymes usually suffer from high production cost, ease of denaturation and inactivation, and low yield, making them difficult to be broadly applicable. As an emerging type of artificial enzyme, nanozymes that combine the characteristics of nanomaterials and enzymes are promising alternatives. On the one hand, nanozymes have high enzyme-like catalytic activities to regulate biochemical reactions. On the other hand, nanozymes also inherit the properties of nanomaterials, which can ameliorate the shortcomings of natural enzymes and serve as versatile platforms for diverse applications. In this review, various nanozymes that mimic the catalytic activity of different enzymes are introduced. The achievements of nanozymes in different cancer diagnosis and treatment technologies are summarized by highlighting the advantages of nanozymes in these applications. Finally, future research directions in this rapidly developing field are outlooked."Image missing"

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Section: Introductionmentioning

confidence: 99%

Nanozymes: Versatile Platforms for Cancer Diagnosis and Therapy

2022

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“…Conventional fluorescence imaging generally adopts visible light as the excitation light source, and the generated fluorescence is usually located in the visible light region 90 . The high absorption and scattering of these lights by human tissues lead to a short penetration depth of conventional fluorescence imaging 91 .…”

Section: Rons Imaging Probesmentioning

confidence: 99%

Emerging early diagnostic methods for acute kidney injury

Xiao¹,

Huang²,

Yang³

et al. 2022

Theranostics

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Many factors such as trauma and COVID-19 cause acute kidney injury (AKI). Late AKI have a very high incidence and mortality rate. Early diagnosis of AKI provides a critical therapeutic time window for AKI treatment to prevent progression to chronic renal failure. However, the current clinical detection based on creatinine and urine output isn't effective in diagnosing early AKI. In recent years, the early diagnosis of AKI has made great progress with the advancement of information technology, nanotechnology, and biomedicine. These emerging methods are mainly divided into two aspects: First, predicting AKI through models construct by machine learning; Second, early diagnosis of AKI through detection of newly-discovered early biomarkers. Currently, these methods have shown great potential and become an attractive tool for the early diagnosis of AKI. Therefore, it is very important to discuss and summarize these methods for the early diagnosis of AKI. In this review, we first systematically summarize the application of machine learning in AKI prediction algorithms and specific scenarios. In addition, we introduce the key role of early biomarkers in the progress of AKI, and then comprehensively summarize the application of emerging detection technologies for early AKI. Finally, we discuss current challenges and prospects of machine learning and biomarker detection. The review is expected to provide new insights for early diagnosis of AKI, and provided important inspiration for the design of early diagnosis of other major diseases.

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“…103–106 Generally, COFs are chemically stable in water and organic solvents as well as under acidic, alkaline, and oxidizing conditions. These features enable the use of COFs as functional materials for various applications under different conditions, including for adsorption and separation, 107–111 catalysis, 112–115 nanomedicine, 116–120 sensing, 121–124 photochemistry, 125 electrochemistry, 126 energy storage, 127 and many others.…”

Section: Introductionmentioning

confidence: 99%