Chinese Alcoholic Patients With Esophageal Cancer Are Genetically Different From Alcoholics With Acute Pancreatitis and Liver Cirrhosis

You, Chao; Wang, Liang Shun; Hsieh, Tsai Yuan; Chu, Chen Wei; Chang, Full Young; Chu, Heng-Cheng

doi:10.1111/j.1572-0241.2000.02328.x

Cited by 84 publications

(53 citation statements)

References 17 publications

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“…The hazard ratio of hospitalization for alcoholism in men and women with the slow alcohol degradation ADH1B Á 1/1 genotype was 3.9 (95% CI: 1.0-16) and 2.7 (95% CI: 0. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20].…”

Section: Resultsmentioning

confidence: 99%

Alcoholism and alcohol drinking habits predicted from alcohol dehydrogenase genes

et al. 2007

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Alcohol drinking habits and alcoholism are partly genetically determined. Alcohol is degraded primarily by alcohol dehydrogenase (ADH) wherein genetic variation that affects the rate of alcohol degradation is found in ADH1B and ADH1C. It is biologically plausible that these variations may be associated with alcohol drinking habits and alcoholism. By genotyping 9080 white men and women from the general population, we found that men and women with ADH1B slow vs fast alcohol degradation drank more alcohol and had a higher risk of everyday drinking, heavy drinking, excessive drinking and of alcoholism. For example, the weekly alcohol intake was 9.8 drinks (95% confidence interval (CI): 9.1-11) among men with the ADH1B Á 1/1 genotype compared to 7.5 drinks (95% CI: 6.4-8.7) among men with the ADH1B Á 1/2 genotype, and the odds ratio (OR) for heavy drinking was 3.1 (95% CI: 1.7-5.7) among men with the ADH1B Á 1/1 genotype compared to men with the ADH1B Á 1/2 genotype. Furthermore, individuals with ADH1C slow vs fast alcohol degradation had a higher risk of heavy and excessive drinking. For example, the OR for heavy drinking was 1.4 (95% CI: 1.1-1.8) among men with the ADH1C Á 1/2 genotype and 1.4 (95% CI: 1.0-1.9) among men with the ADH1B Á 2/2 genotype, compared with men with the ADH1C Á 1/1 genotype. Results for ADH1B and ADH1C genotypes among men and women were similar. Finally, because slow ADH1B alcohol degradation is found in more than 90% of the white population compared to less than 10% of East Asians, the population attributable risk of heavy drinking and alcoholism by ADH1B Á 1/1 genotype was 67 and 62% among the white population compared with 9 and 24% among the East Asian population.

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Section: Resultsmentioning

confidence: 99%

Alcoholism and alcohol drinking habits predicted from alcohol dehydrogenase genes

et al. 2007

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“…Furthermore, persons with combined genotypes of ADH2 G/G and ALDH2 G/A are at a high risk of developing esophageal squamous cell carcinoma. Chao et al [14] reported that Chinese alcoholic patients with ADH2 G and ALDH2 A alleles are more susceptible to esophageal cancer. However, Ohhira et al [15] showed that 10 patients with hepatocellular carcinoma (HCC) associated with pure alcoholic liver disease all have ALDH2 G/G genotype.…”

Section: Discussionmentioning

confidence: 99%

“…In theory, when ADH2 activity is increased or ALDH2 activity is decreased, the blood acetaldehyde level also increases in drinkers, thus increasing the risk of developing colorectal cancer. However, inconsistent results have been reported in many studies on the relation between ADH2 and ALDH2 gene polymorphisms and cancer susceptibility [11][12][13][14][15][16][17][18] . Yokoyama et al [11] found ALDH2 G/A genotype encoding inactive ALDH2 and ADH2 G/G genotype encoding the low-activity form of ADH2 can enhance the risk of esophageal cancer in Japanese alcoholics.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 and colorectal cancer risk in Chinese males

Gao¹,

Takezaki²,

Wu³

et al. 2008

WJG

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AIM: To evaluate the relationship between drinking and polymorphisms of alcohol dehydrogenase 2 (ADH2 ) and/or aldehyde dehydrogenase 2 (ALDH2 ) for risk of colorectal cancer (CRC) in Chinese males. METHODS: A case-control study was conducted in 190 cases and 223 population-based controls. ADH2 Arg47His (G-A) and ALDH2 Glu487Lys (G-A) genotypes were identified by PCR and denaturing high-performance liquid chromatography (DHPLC). Information on smoking and drinking was collected and odds ratio (OR) was estimated. RESULTS:

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“…3 Most studies, conducted mainly in Japan, have revealed associations between the ADH2 or ALDH2 polymorphism and esophageal cancer risk. [4][5][6][7][8] Chao et al 9 found that Chinese alcoholic patients with the ADH2 G and ALDH2 A alleles were more susceptible to esophageal cancer. Wu et al 10 also found a multiplicative effect of lifetime alcoholic consumption and genotypes (ADH2 and ALDH2) on esophageal cancer risk, but those were only found in Taiwanese males.…”

Section: Introductionmentioning

confidence: 99%

Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for esophageal cancer in a Chinese population

Ding

Cao

et al. 2009

J Hum Genet

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To investigate the relationship among alcohol dehydrogenase-2 (ADH2) and aldehyde dehydrogenase-2 (ALDH2) genetic polymorphisms, alcohol consumption and the susceptibility to esophageal cancer in a Chinese population, we conducted a case-control study with 221 cases and 191 population-based controls in the Taixing city of Jiangsu Province of China. ADH2 and ALDH2 genotypes were examined using PCR and denaturing high-performance liquid chromatography. Alcohol drinkers with the ALDH2 A allele showed a significantly increased risk of esophageal cancer compared with drinkers with the ALDH2 G/G genotype (odds ratio (OR)¼3.08, 95% confidence interval ( Keywords: alcohol dehydrogenase 2; aldehyde dehydrogenase 2; alcohol drinking; case-control study; esophageal cancer INTRODUCTION Epidemiological studies have consistently shown that alcohol drinking is a risk factor for esophageal cancer. 1 When ethanol is consumed, it is metabolized primarily by alcohol dehydrogenase (ADH) into acetaldehyde, an intermediate metabolite, and then it is metabolized by aldehyde dehydrogenase (ALDH) into acetic acid. 2 Acetaldehyde, a well-known carcinogen in animals, has an important role in alcohol toxicity in humans. 3 Most studies, conducted mainly in Japan, have revealed associations between the ADH2 or ALDH2 polymorphism and esophageal cancer risk. [4][5][6][7][8] found that Chinese alcoholic patients with the ADH2 G and ALDH2 A alleles were more susceptible to esophageal cancer. Wu et al. 10 also found a multiplicative effect of lifetime alcoholic consumption and genotypes (ADH2 and ALDH2) on esophageal cancer risk, but those were only found in Taiwanese males.Taixing City, located in the middle part of Jiangsu Province, China, has relatively high incidence and mortality rates for esophageal cancer

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Chinese Alcoholic Patients With Esophageal Cancer Are Genetically Different From Alcoholics With Acute Pancreatitis and Liver Cirrhosis

Cited by 84 publications

References 17 publications

Alcoholism and alcohol drinking habits predicted from alcohol dehydrogenase genes

Alcoholism and alcohol drinking habits predicted from alcohol dehydrogenase genes

Polymorphisms of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 and colorectal cancer risk in Chinese males

Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for esophageal cancer in a Chinese population

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