Polymorphisms of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 and colorectal cancer risk in Chinese males

Gao, Chang–Ming; Takezaki, Toshiro; Wu, Jianzhong; Zhang, Xiaomei; Cao, Hongyan; Ding, Jiannan; Liu, Yanting; Li, Suping; Cao, Jia; Matsuo, Keitaro; Hamajima, Nobuyuki; Tajima, Kazuo

doi:10.3748/wjg.14.5078

Cited by 41 publications

(46 citation statements)

References 17 publications

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“…13,14 In this study, we found that the protective effect of the GH1 1663A/A genotype for colorectal cancer was more notable in nonsmokers of cigarettes and nondrinkers of alcohol. The relationship between GH1 and habitual smoking and drinking is unclear, but GH1 increases production of both IGF-1 and IGFBP-3, accounting in part for the relatively high correlation between plasma IGF-1 and IGFBP-3.…”

Section: Discussionmentioning

confidence: 52%

Relationship between growth hormone 1 genetic polymorphism and susceptibility to colorectal cancer

Gao

Gong

et al. 2010

J Hum Genet

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The aim of this study was to evaluate the relationship between smoking, alcohol drinking and genetic polymorphism of the growth hormone 1 gene (GH1) T1663A with reference to colorectal cancer. We conducted a case-control study with 315 cases of colorectal cancer and 438 population-based controls in the Jiangsu Province, China. GH1 T1663A genotypes were identified using PCR-RFLP (restriction fragment length polymorphism) methods. Information on smoking and drinking was collected using a questionnaire. Odds ratios (ORs) were estimated with an unconditional logistic model. The distribution of T/T and A/A genotypes was significantly different between controls and cases (v 2 MH ¼3.877, P¼0.049). Compared with the GH1 T/T genotype, the A/A genotype was at a decreased risk of developing colorectal cancer (sex-, age-, body mass index-, smokingand alcohol drinking-adjusted OR¼0.56, 95% confidence interval: 0.34-0.90). Smoking was not associated with the risk of colorectal cancer, whereas alcohol drinking was associated with an increased risk of colorectal cancer. Among nonsmokers or nondrinkers, individuals who had the GH1 A/A genotype were at a decreased risk of developing colorectal cancer compared with individuals who had the GH1 T allele. These results show that the GH1 T1663A A/A genotype can decrease the risk for colorectal cancer.

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Section: Discussionmentioning

confidence: 52%

Relationship between growth hormone 1 genetic polymorphism and susceptibility to colorectal cancer

Gao

Gong

et al. 2010

J Hum Genet

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“…Neither was there a significant gene-environment interaction between alcohol consumption and polymorphisms in ADH1B rs1229984 and ALDH2 rs671 (18). In a recent study in a Chinese Han population, Gao et al found that rs671 A/G and A/A genotypes were protective against the risk of colorectal cancer (19). However another study by Sangrajrang et al did not find any affect of the ALDH2 rs671 polymorphism on the risk of breast cancer (20).…”

Section: Discussionmentioning

confidence: 87%

A variant allele of ADH1B and ALDH2, is associated with the risk of esophageal cancer

Gong

Ding

et al. 2012

Experimental and Therapeutic Medicine

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Abstract. Alcoholic beverages are causally related to esophageal cancer. The genetic polymorphisms of the alcohol-metabolizing enzymes ADH1B rs1229984 and ALDH2 rs671 may modulate individual differences in alcohol-oxidizing capability. A case-control study was conducted to evaluate the genetic effects of these two functional single nucleotide polymorphisms (SNPs) on the development of esophageal cancer. A total of 380 esophageal squamous cell carcinoma cases and 380 controls were recruited. Genotypes were determined by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Variant alleles of the functional polymorphism ADH1B rs1229984 SNP were associated with an increased risk of esophageal cancer [adjusted odds ratio (OR)=2.39, 95% confidence interval (CI)=1.42-4.03 for ADH1B rs1229984 GG vs. AA]. There was a borderline-significantly decreased risk between the ALDH2 rs671 genotype and esophageal cancer (adjusted OR=0.47, 95% CI=0.22-1.00 for ALDH2 rs671 AA vs. GG). Stratified analyses indicated that both of these effects were more evident among male, younger subjects and smokers. In conclusion, the functional polymorphisms ADH1B rs1229984 and ALDH2 rs671 may contribute to susceptibility to esophageal cancer, particularly among male, younger subjects and smokers. IntroductionEsophageal cancer is an extremely aggressive cancer, of which China has high-incidence regions (1). Esophageal squamous cell carcinoma (ESCC) is a subtype of esophageal cancer which accounts for >90% of cases (2). Esophageal cancer is known to be associated with environmental carcinogens. Epidemiological studies indicate that use of tobacco and consumption of alcohol are major risk factors for esophageal cancer. However, only a subset of individuals exposed to tobacco and alcohol develop esophageal cancer, suggesting a role of host susceptibility factors in cancer development. The genetic basis of esophageal cancer is complex and appears to involve multiple genes. Some studies have suggested that genetic polymorphisms might explain individual differences in susceptibility to esophageal cancer (3).Alcohol intake may be causally related to cancer of the oral cavity, pharynx, larynx and esophagus. Ethanol is oxidized to acetaldehyde and then to acetate by alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH); both of which have genetic polymorphisms. The genetic polymorphisms of alcohol-metabolizing enzymes modulate individual differences in alcohol-oxidizing capability and drinking behavior (4).In humans, the major enzymes involved in the alcohol-metabolizing pathways are alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2). Alcohol is first oxidized by ADH to acetaldehyde, which is oxidized to acetate by ALDH. These enzymes are mainly expressed in the liver, but are also present in the gastrointestinal tract (5). A variant allele of

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“…Genotyping of ADH2 and ALDH2 was determined by PCR and denaturing high-performance liquid chromatography. 13 There were three genotypes, namely, G/G, G/A and A/A, for ADH2 Arg47His(rs1229984) and ALDH2 Glu487Lys(rs671, ss676), respectively.…”

Section: Dna Extraction and Genotypingmentioning

confidence: 99%

Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for esophageal cancer in a Chinese population

Ding

Cao

et al. 2009

J Hum Genet

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To investigate the relationship among alcohol dehydrogenase-2 (ADH2) and aldehyde dehydrogenase-2 (ALDH2) genetic polymorphisms, alcohol consumption and the susceptibility to esophageal cancer in a Chinese population, we conducted a case-control study with 221 cases and 191 population-based controls in the Taixing city of Jiangsu Province of China. ADH2 and ALDH2 genotypes were examined using PCR and denaturing high-performance liquid chromatography. Alcohol drinkers with the ALDH2 A allele showed a significantly increased risk of esophageal cancer compared with drinkers with the ALDH2 G/G genotype (odds ratio (OR)¼3.08, 95% confidence interval ( Keywords: alcohol dehydrogenase 2; aldehyde dehydrogenase 2; alcohol drinking; case-control study; esophageal cancer INTRODUCTION Epidemiological studies have consistently shown that alcohol drinking is a risk factor for esophageal cancer. 1 When ethanol is consumed, it is metabolized primarily by alcohol dehydrogenase (ADH) into acetaldehyde, an intermediate metabolite, and then it is metabolized by aldehyde dehydrogenase (ALDH) into acetic acid. 2 Acetaldehyde, a well-known carcinogen in animals, has an important role in alcohol toxicity in humans. 3 Most studies, conducted mainly in Japan, have revealed associations between the ADH2 or ALDH2 polymorphism and esophageal cancer risk. [4][5][6][7][8] found that Chinese alcoholic patients with the ADH2 G and ALDH2 A alleles were more susceptible to esophageal cancer. Wu et al. 10 also found a multiplicative effect of lifetime alcoholic consumption and genotypes (ADH2 and ALDH2) on esophageal cancer risk, but those were only found in Taiwanese males.Taixing City, located in the middle part of Jiangsu Province, China, has relatively high incidence and mortality rates for esophageal cancer

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Polymorphisms of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 and colorectal cancer risk in Chinese males

Cited by 41 publications

References 17 publications

Relationship between growth hormone 1 genetic polymorphism and susceptibility to colorectal cancer

Relationship between growth hormone 1 genetic polymorphism and susceptibility to colorectal cancer

A variant allele of ADH1B and ALDH2, is associated with the risk of esophageal cancer

Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for esophageal cancer in a Chinese population

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