Relationship between growth hormone 1 genetic polymorphism and susceptibility to colorectal cancer

Gao, Chang–Ming; Gong, Jianping; Wu, Jianzhong; Cao, Hongyan; Ding, Jiannan; Zhou, Jian; Liu, Yanting; Li, Suping; Cao, Jia; Matsuo, Keitaro; Takezaki, Toshiro; Tajima, Kazuo

doi:10.1038/jhg.2010.3

Cited by 9 publications

(10 citation statements)

References 20 publications

(15 reference statements)

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“…Our results with GH1 are supported by two previous reports 14 15. Le Marchand et al initally suggested a reduction in risk of colorectal cancer with the homozygous variant genotype 14, and results from Gao and colleagues also report a reduced risk of colorectal cancer associated with this same GH1 genetic variant 15.…”

Section: Discussionsupporting

confidence: 90%

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Body size, IGF and growth hormone polymorphisms, and colorectal adenomas and hyperplastic polyps

Wernli¹,

Newcomb²,

Wang³

et al. 2010

Growth Hormone & IGF Research

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Objective-We examined the risk of colorectal polyps in relation to body size factors and candidate polymorphisms in selected genes of insulin-like growth factor (IGF1) (rs5742612), IGF1 receptor (IGF1R) (rs2229765), IGF binding protein 3 (IGFBP3) (rs2854746) and growth hormone (GH1) (rs2665802).Design-Cases with colorectal adenomas (n=519), hyperplastic polyps (n=691), or both lesions (n=227), and controls (n=772), aged 20-74 years, were recruited from patients who underwent colonoscopy between December 2004 -September 2007 at a large integrated-health plan in Washington state. Subjects participated in a 45-minute telephone interview to ascertain body size and physical activity, and provided a buccal DNA sample for genetic analysis. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable polytomous regression.Results-Compared to those of normal weight, higher body mass index (BMI) was associated with elevated risk of colorectal adenomas (OR=1.7, 95% CI 1.2-2.3 BMI≥30 kg/m 2 , ptrend=0.002) and both lesions (OR=2.2, 95% CI 1.4-3.2 BMI≥30 kg/m 2 , p-trend=0.003), but there was no relationship with hyperplastic polyps. Obesity at age 18 and a weight gain of ≥21 kg since age 18 were also significantly associated with an increased risk of colorectal adenomas and both lesions, but not hyperplastic polyps. There was a reduced risk of colorectal adenomas (OR=0.6, 95% CI 0.4-0.9) and hyperplastic polyps (OR=0.7, 95% CI 0.5-0.9) associated with the homozygous variant genotype for GH1. Few meaningful results were evident for the other polymorphisms.Conclusions-There is an increased risk of colorectal adenomas and presence of both adenomas and hyperplastic polyps in relation to increasing body size. Some genetic variation in GH1 might contribute to a reduced risk of colorectal adenomas and hyperplastic polyps.

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Section: Discussionsupporting

confidence: 90%

“…Thus, it is reasonable to consider that polymorphisms which may affect these hormonal concentrations could also be associated with precursor lesions. Two studies study has demonstrated that a genetic polymorphism in GH1 is associated with a decreased colorectal cancer risk 14,15…”

Section: Introductionmentioning

confidence: 99%

Body size, IGF and growth hormone polymorphisms, and colorectal adenomas and hyperplastic polyps

Wernli¹,

Newcomb²,

Wang³

et al. 2010

Growth Hormone & IGF Research

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“…Smoking is an important environmental risk factor in human cancers, but in previous study (Gao et al, 2010), we found no relationship between cigarette smoking and colorectal cancer risk. In the present study, we also found no interaction between smoking and XRCC1 polymorphisms on the risk of colorectal cancer.…”

Section: Discussionmentioning

confidence: 70%

“…The background characteristics of cases and controls have been described in previous articles (Cao et al, 2008;Gao et al, 2010). The proportional distribution of females in controls was higher than that in colorectal cases.…”

Section: Resultsmentioning

confidence: 93%

Polymorphisms in XRCC1 Gene, Alcohol drinking, and Risk of Colorectal Cancer: a Case-control Study in Jiangsu Province of China

Gao¹,

Ding²,

Li³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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To evaluate the relationship between alcohol drinking, XRCC1 codon 194 and 399 polymorphisms and risk of colorectal cancer, we conducted a case-control study with 315 colorectal cancer cases (105 colon, 210 rectal) and 439 population-based controls in Jiangsu Province of China. The XRCC1 codon 194 and 399 genotypes were identified using polymerase chain reaction and restrictrion fragment length polymorphism methods (PCR-RFLP). A structured questionnaire was used to elicit detailed information. Odds ratios (ORs) were estimated with an unconditional logistic model. In this study no significant differences were observed among the studied groups with regard to the genotype distribution of the XRCC1 codons 194 and 399 and the risk of colorectal cancer did not appear to be significantly influenced by genotype alone, whereas alcohol consumption showed a positive association (P for trend <0.01). When combined effects of XRCC1 polymorphisms and alcohol consumption were analyzed, we found that the 194Trp or 399Gln alleles further increased the colorectal cancer risk due to high alcohol intake. These findings support the conclusion that colorectal cancer susceptibility may be altered by gene-environment interactions.

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“…The background characteristics of cases and controls have been described previously (Gao et al, 2010). The proportional distribution of females in controls was significantly higher than that in colorectal cases.…”

Section: Resultsmentioning

confidence: 88%

Polymorphisms in the Thymidylate Synthase Gene and Risk of Colorectal Cancer

Gao¹,

Ding²,

Li³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Relationship between growth hormone 1 genetic polymorphism and susceptibility to colorectal cancer

Cited by 9 publications

References 20 publications

Body size, IGF and growth hormone polymorphisms, and colorectal adenomas and hyperplastic polyps

Body size, IGF and growth hormone polymorphisms, and colorectal adenomas and hyperplastic polyps

Polymorphisms in XRCC1 Gene, Alcohol drinking, and Risk of Colorectal Cancer: a Case-control Study in Jiangsu Province of China

Polymorphisms in the Thymidylate Synthase Gene and Risk of Colorectal Cancer

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