Chilean pilot study on the risk of lung cancer associated with codon 72 polymorphism in the gene of protein p53

TP53 Pro47Ser and Arg72Pro polymorphisms and colorectal cancer predisposition in an ethnic Kashmiri population

“…Although most polymorphisms are functionally neutral, some affect regulation of gene expression or the function of the coded protein (Costa et al, 2008). Several studies have been carried out on the association of TP53 polymorphism with increased risk for various cancers (Sjalander et al, 1996;Thomas et al, 1999;Lee et al, 2000;Hiyama et al, 2002;Irarrazabal et al, 2003;Zhu et al, 2007). However, in CRC the data available on the TP53 polymorphic status are somewhat ambiguous, where several studies found no association (Sjalander et al, 1995;Sayhan et al, 2001;Hamajima et al, 2002;Schneider-Stock et al, 2004).…”

Association of <i>p53 codon 248</i> (<i>exon7</i>) with urinary bladder cancer risk in the North Indian population

“…Several studies have reported on association of p53 polymorphisms with increased risk for various cancers such as esophageal (9), gastric (10), lung carcinoma (11) and colorectal cancer (12), respectively. Although the possibility that polymorphic variants in p53 might contribute to cancer susceptibility has been extensively investigated, the issue remains highly complicated.…”

Famacogénica del cáncer: Estudio de variaciones genéticamente determinadas en la susceptibilidad a cáncer por exposición a xenobióticos

“…Es por ello que la farmacogenética persigue la búsqueda y evaluación de múltiples factores o biomarcadores que en su conjunto describan en mejor forma el potencial genético-metabólico individual frente a cancerígenos. En este contexto, paralelamente se estudian variantes alélicas de antioncogenes, enzimas de reparación y genes de resistencia a drogas 116,[120][121][122][123][124][125][126][127] . Asimismo, otro aspecto de gran interés es el estudio de aquellas enzimas de biotransformación específicamente asociadas al metabolismo de los más de 100 agentes químicos utilizados en quimioterapia.…”