Childhood trachoma in a nonendemic area. Danish trachoma patients and their close contacts, 1963 to 1973

Mordhorst, Carl H.; Wang, San-Pin; Grayston, J. T.

doi:10.1001/jama.239.17.1765

Cited by 18 publications

(2 citation statements)

References 9 publications

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“…However, the acute inflammatory changes always subsided and, in the absence of bacterial infection, did not lead to chronic progressive changes. The limited extension of superficial blood vessels in the cornea resembled the micropannus observed by Mordhorst et al in children after protracted eye infection with genital chlamydiae (14).…”

Section: Discussionsupporting

confidence: 65%

Long-term clinical, microbiological, and immunological observations of a volunteer repeatedly infected with Chlamydia trachomatis

Hanna¹,

Jawetz²,

Dawson³

et al. 1982

J Clin Microbiol

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A blind volunteer was inoculated in one eye with an isolate of Chlamydia trachomatis in 1961 and followed for 20 years. During this time, many observations were made of his clinical responses to the first inoculation and several subsequent inoculations with the same and other strains, chlamydial shedding, and antibody and cell-mediated immune responses. Evidence is presented that partial resistance to chlamydial eye infection developed during repeated infections and that antibodies, cell-mediated immune reactions, and specific antigen in conjunctival cells persisted for many years after the last infection. The antibody response was directed mainly against the original infecting immunotype, regardless of whether the response was restimulated by infection with the same immunotype or with other immunotypes. The lymphocyte stimulation response appeared to be species specific.

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Section: Discussionsupporting

confidence: 65%

Long-term clinical, microbiological, and immunological observations of a volunteer repeatedly infected with Chlamydia trachomatis

Hanna¹,

Jawetz²,

Dawson³

et al. 1982

J Clin Microbiol

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“…'5 162930 Isolation of C trachomatis from infected Fallopian tubes has confirmed that this agent is a major cause of salpingitis;31133 isolation from Bartholin's ducts shows that it causes bartholinitis.34 It is the commonest cause of epididymitis in young men.35 Because C trachomatis is sexually transmitted, it is commonly associated with other sexually transmitted infections;3 15 Chlamydial ophthalmia neonatorum may cause local complications in the eye if treatment is started after the thirteenth day of life,30 or if reinfection occurs. 38 The incubation of chlamydial ophthalmia is often longer than that of the gonococcal form, but chlamydial ophthalmia may be present at birth and both forms may occur after caesarian section, if this is carried out after the membranes have ruptured. Infants are commonly premature,'6 which may be due to infection of fetal membranes over the infected cervix.…”

Section: Complications Of Chlamydial Infectionmentioning

confidence: 99%

Epidemiology of infection by serotypes D to K of chlamydia trachomatis.

Dunlop¹,

Darougar²,

Treharne³

1980

Sexually Transmitted Infections

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Erythromycin Ointment for Ocular Prophylaxis of Neonatal Chlamydial Infection

Hammerschlag

Chandler

Alexander

et al. 1980

JAMA

101

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We compared the efficacy of erythromycin ophthalmic ointment vs 1% silver nitrate drops for the prevention of neonatal conjunctivitis or respiratory tract infection from Chlamydia trachomatis. The organism was isolated from the cervix of 67 (12%) of 572 pregnant women. They gave birth to 559 infants who were randomly assigned to either prophylaxis immediately after birth. Thirty-six of 60 infants born to Chlamydia-positive women received silver nitrate; 24 received erythromycin. Twelve (33%) of the 36 infants who received silver nitrate had chlamydial conjunctivitis, but none of the 24 infants who received erythromycin did. Ten (29%) of 36 infants receiving silver nitrate had chlamydial nasopharyngeal infection (three later had pneumonia), as opposed to five (21%) of 24 who received erythromycin (one had pneumonia). Thus, erythromycin ointment is effective in prevention of chlamydial conjunctivitis, but it may not reduce nasopharyngeal infection or subsequent pneumonia.

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Childhood trachoma in a nonendemic area. Danish trachoma patients and their close contacts, 1963 to 1973

Cited by 18 publications

References 9 publications

Long-term clinical, microbiological, and immunological observations of a volunteer repeatedly infected with Chlamydia trachomatis

Long-term clinical, microbiological, and immunological observations of a volunteer repeatedly infected with Chlamydia trachomatis

Epidemiology of infection by serotypes D to K of chlamydia trachomatis.

Erythromycin Ointment for Ocular Prophylaxis of Neonatal Chlamydial Infection

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