Childhood- and later-onset vitiligo have diverse epidemiologic and clinical characteristics

Early-onset childhood vitiligo is associated with a more extensive and progressive course

“…Similar rates of disease progression were found in a study of 126 pediatric and 107 adult patients, where the mean number of years from disease onset until progression to other sites was 4.1 and 2.7 years for childhood-versus adult-onset groups (P \ .06). 6 Taken together, earlier onset of disease may be associated with a greater predisposition for progression and prolonged disease course.…”

“…4 Although adult-and childhoodonset vitiligo share similar features, a few key differences have been identified. Compared with their adult counterparts, pediatric patients with vitiligo have a higher proportion of segmental vitiligo 1,5,6 and lower rates of associated autoimmune diseases. 7,8 Little is known about the characteristics of vitiligo presenting in early childhood (\3 years of age).…”

A Practical Approach to the Diagnosis and Treatment of Vitiligo in Children

“…24 The term "universalis" refers to the almost virtually universal depigmentation (>60% to 90% of the body surface area) (Fig 2). Hairs may be partially spared.…”

Halo Nevus Arising from Congenital Melanocytic Nevus Featuring an Early Onset Vitiligo

“…Barona et al [8] stated that the presence of a halo nevus indicates a risk factor of vitiligo progression and a prospective observational study suggest that non-segmental vitiligo-associated halo nevus affects age of onset and depigmentation pattern, and has a more frequent familial background of autoimmunity [9]. Moreover, patients with multiple non-segmented vitiligo with congenital melanocytic nevus had a higher frequency of halo nevi at distance, which suggests a relationship between vitiligo and halo nevus [9,10]. This relation was even more significant in halo nevus from congenital melanocytic nevus with higher presentation of vitiligo.…”