Chilblain lupus erythematosus is associated with antibodies to SSA/Ro

Franceschini, Franco; Calzavara-Pinton, P; Quinzanini, M; Cavazzana, Ilaria; Bettoni, Lorenzo; Zane, Cristina; Facchetti, Fabio; Airò, Paolo; McCauliffe, Daniel P.; Cattaneo, Roberto

doi:10.1191/096120399678847632

Cited by 47 publications

(11 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pathological features are similar to those observed in DLE. Contrary to the results of Franceschini et al, 32 there was no association in this study between chilblain lupus and the presence of anti-Ro/SSA antibodies.…”

Section: Discussioncontrasting

confidence: 86%

Cutaneous lesions of the digits in systemic lupus erythematosus: 50 cases

Bouaziz¹,

Barète

Pelletier

et al. 2007

Lupus

View full text Add to dashboard Cite

The objective of this study was to observe the clinical and pathologic features of digital lesions in a cohort of 50 patients with systemic lupus erythematosus (SLE). Biopsy and pictures of digital lesions were performed in 50 consecutive patients with SLE and digital lesions. A clinical diagnosis of vasculitis was previously suggested in 36% of cases. Pictures were reviewed by three dermatologists and all the tissue sections were analysed by the same pathologist. Files of patients were reviewed retrospectively. Activity of SLE was established according to the lupus activity index (LAI). Digital lesions in SLE were frequently painful (60%) with a finger-pulp inflammation (70%). According to clinical and pathological correlation, five patients had acute cutaneous lupus, five subacute cutaneous lupus, 21 discoid lupus and 15 chilblain lupus. Two patients presented vasculitis: one had an urticarial vasculitis concomitantly to a lupus flare, the other had an erythema elevatum diutinum, independent of SLE evolution. Thrombosis of dermal vessels was present in two patients with SLE-associated antiphospholipid syndrome and in two patients with chilblain lupus. LAI was >1.5 in only seven patients. These results highlight the tendency to clinically overestimate the prevalence of cutaneous vasculitis of the fingers in patients without active SLE. Clinical features of cutaneous lupus of the digits are polymorphous. So, a pathological examination of the lesions is often necessary for diagnosis and proper management.

show abstract

Section: Discussioncontrasting

confidence: 86%

Cutaneous lesions of the digits in systemic lupus erythematosus: 50 cases

Bouaziz¹,

Barète

Pelletier

et al. 2007

Lupus

View full text Add to dashboard Cite

show abstract

“…Anti-Ro/SsA and antiphospholipid antibodies have also been found to be positive in a few studies. [ 7 ] Su et al .,[ 8 ] proposed the Mayo Clinic Diagnostic criteria for a confirmative diagnosis of CHLE. Major criteria include skin lesions in acral locations induced by exposure to cold or a drop in temperature, and evidence of lupus erythematosus in the skin lesions by histopathologic examination or DIF.…”

Section: Discussionmentioning

confidence: 99%

Chilblain lupus erythematosus in an adolescent girl

Bansal

Goel²

2014

Indian Dermatol Online J

View full text Add to dashboard Cite

Chilblain Lupus Erythematosus (CHLE) is a rare form of cutaneous lupus erythematosus (LE), more frequently seen in middle aged females. It is characterized by erythematous to violaceous plaques over the acral areas induced by exposure to cold or drop in temperature unlike lesions of lupus erythematosus that worsen with sun exposure. Here, we present a case of chilblain lupus erythematosus in an adolescent girl with few unique features not previously reported.

show abstract

“…Previous studies also reported higher frequency of nailfold bleeding in SLE patients than in normal subjects. 22,29 Andrade et al 3 inferred that the occurrence of micropetechiae of focal distribution was related to everyday microtrauma that may occur in healthy individuals. They also stated that because it is a dynamic phenomenon, agreement may be low in two consecutive readings (72%) with variable intervals from weeks to months.…”

Section: Resultsmentioning

confidence: 99%

Achados capilaroscópicos no lúpus eritematoso

Facina

Pucinelli

Vasconcellos

et al. 2006

An. Bras. Dermatol.

View full text Add to dashboard Cite

BACKGROUND -Capillaroscopy is an useful diagnostic tool that is non-invasive, reproducible, able to assess the capillaries in the periungal region and that assists in the differential diagnosis of connective tissue diseases. OBJETIVES -The aim of the study was to distinguish chronic cutaneous lupus erythematosus and systemic lupus erythematosus from controls assessed by nailfold capillaroscopy. METHODS -Seventy patients with lupus erythematosus (37 with chronic cutaneous lupus erythematosus and 33 with systemic lupus erythematosus) were studied by the technique of capillary microscopy and compared to 32 controls. RESULTS -The presence of ectatic (p=0.027; p=0.001), meandering (p=0.001; p=0.007), corkscrew capillaries (p=0.011; p=0.005) and nailfold bleeding (p=0.004; p=0.001) distinguished between the two groups of patients (chronic cutaneous lupus erythematosus and systemic lupus erythematosus) from controls. The variable meandering loops could be predictive for systemic lupus erythematosus (OR=8.308). The independent variables ectatic loops (OR=12.164) end nailfold bleedings (OR=5.652) were predictive for chronic cutaneous lupus erythematosus. CONCLUSIONSCapillaroscopy can help in the management of patients, since the presence of typical capillaroscopic abnormalities seems to be related to the development of lupus erythematosus. The independent predictive variables for systemic lupus erythematosus were meandering loops, and, for chronic cutaneous lupus erythematosus, ectasic loops and nailfold bleedings. Keywords: Capillaries; Lupus erythematosus, discoid; Lupus erythematosus, systemic; Microscopic angioscopy (p=0,027; p=0,001), enovelados (p=0,001; p=0,007) e em saca-rolhas (p=0,011;p=0,005), além de hemorragias capilares (p=0,004; p=0,001) Resumo: FUNDAMENTOS -A capilaroscopia é método não invasivo e reprodutível capaz de analisar diretamente os capilares na região periungueal, auxiliando no diagnóstico diferencial das doenças do tecido conectivo. OBJETIVOS -Estudar, por meio da capilaroscopia periungueal, pacientes com lúpus eritematoso cutâneo crôni-co, lúpus eritematoso sistêmico e grupo controle. MÉTODOS -Foram analisados 70 pacientes pela capilaroscopia periungueal, sendo 37 com lúpus eritematoso cutâneo crônico e 33 com forma sistêmica, comparados a 32 indivíduos sadios. RESULTADOS -A presença de capilares ectasiados

show abstract

Chilblain lupus erythematosus is associated with antibodies to SSA/Ro

Cited by 47 publications

References 15 publications

Cutaneous lesions of the digits in systemic lupus erythematosus: 50 cases

Cutaneous lesions of the digits in systemic lupus erythematosus: 50 cases

Chilblain lupus erythematosus in an adolescent girl

Achados capilaroscópicos no lúpus eritematoso

Contact Info

Product

Resources

About