Chikungunya

Hassan, Rashedul; Rahman, MM; Moniruzzaman, Md.; Rahim, Abdur; Barua, Satyajit; Biswas, Rajib; Biswas, Pranab Kumar; Mowla, Syed Ghulam Mogni; Chowdhury, MA Jalil

doi:10.1186/1752-1947-8-67

Cited by 30 publications

(34 citation statements)

References 8 publications

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“…In fact, this disease manifestation is so common in CHIKV-induced disease, it has been reported that the presence of concurrent high fever and arthralgia has a specificity of 99.6% and positive predictive value of 84.6% for the diagnosis of CHIKV infection [38]. However, it should be noted that other arboviruses such as dengue, Zika, and other alphaviruses can have similar clinical presentations, including fever and arthralgia.…”

Section: Joint Diseasementioning

confidence: 99%

A Review of Chikungunya Virus-induced Arthralgia: Clinical Manifestations, Therapeutics, and Pathogenesis

Goupil

2016

TORJ

105

102

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Background:Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that circulates predominantly in tropical and subtropical regions, potentially affecting over 1 billion people. Recently, an outbreak began in the western hemisphere and has resulted in over 1.8 million reported suspected cases. Infection often results in severe fever, rash and debilitating polyarthralgia lasting weeks to months. Additionally, the current literature reports that CHIKV can result in a severe chronic arthralgia and/or arthritis that can last months to years following the initial infection.Objective:The purpose of this review is to evaluate the literature and summarize the current state of knowledge regarding CHIKV-associated disease, including clinical presentation, diagnosis, risk factors for development of severe disease, treatment, and pathogenesis in human patients. Additionally, recommendations are presented regarding avenues for clinical research to help further elucidate the pathogenesis of joint disease associated with CHIKV infection.Conclusion:While there is an association between initial CHIKV infection and acute disease, a causal relationship with development of chronic arthralgia has not been established at this time. Potential causes of chronic CHIKV-induced arthritis have been postulated, including viral persistence, induction of autoimmune disease, and exacerbation of pre-existing joint disease. While there are numerous reports of chronic CHIKV-associated arthralgia and/or arthritis, there is currently no evidence of a definitive link between initial infection and development of chronic disease. Additional, prospective clinical research on CHIKV-associated disease is necessary to further determine the potential role of virus and development of chronic joint disease.

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Section: Joint Diseasementioning

confidence: 99%

A Review of Chikungunya Virus-induced Arthralgia: Clinical Manifestations, Therapeutics, and Pathogenesis

Goupil

2016

TORJ

105

102

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“…In 1999, in Chittagong Medical College Hospital, a young boy was suspected to have chikungunya (Personal communication Prof M A Faiz). A case series of 6 chikungunya was reported in 2013 27 . Another review was reported in next year with updated information.…”

Section: Bangladesh Situationmentioning

confidence: 99%

Amin¹,

Rahman²,

Islam³

2017

J. Medicine

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“…[1][2][3] The name is derived from the Mekonde word meaning 'that which contorts or bends up' in reference to the stopped posture developed as a result of the arthritic symptoms of the disease. 4 Chikungunya virus or CHIK virus is a Group IV (+) RNA virus belonging to family Togaviridae, Genus Alphavirus and species Cikungunya virus.…”

Section: Introductionmentioning

confidence: 99%