IntroductionEnvironmental enteric dysfunction (EED) is a subacute inflammatory condition of the small intestinal mucosa with unclear aetiology that may account for more than 40% of all cases of stunting. Currently, there are no universally accepted protocols for the diagnosis, treatment and ultimately prevention of EED. The Bangladesh Environmental Enteric Dysfunction (BEED) study is designed to validate non-invasive biomarkers of EED with small intestinal biopsy, better understand disease pathogenesis and identify potential therapeutic targets for interventions designed to control EED and stunting.Methods and analysisThe BEED study is a community-based intervention where participants are recruited from three cohorts: stunted children aged 12–18 months (length for age Z-score (LAZ) <−2), at risk of stunting children aged 12–18 months (LAZ <−1 to −2) and malnourished adults aged 18–45 years (body mass index <18.5 kg/m2). After screening, participants eligible for study provide faecal, urine and plasma specimens to quantify the levels of candidate EED biomarkers before and after receiving a nutritional intervention. Participants who fail to respond to nutritional therapy are considered as the candidates for upper gastrointestinal endoscopy with biopsy. Histopathological scoring for EED will be performed on biopsies obtained from several locations within the proximal small intestine. Candidate EED biomarkers will be correlated with nutritional status, the results of histochemical and immunohistochemical analyses of epithelial and lamina propria cell populations, plus assessments of microbial community structure.Ethics and disseminationEthics approval was obtained in all participating institutes. Results of this study will be submitted for publication in peer-reviewed journals.Trial registration numberClinicalTrials.gov ID: NCT02812615. Registered on 21 June 2016.
Objective: Not only has COVID-19 caused unprecedented changes in every sphere of human lives, but it has also simultaneously triggered a wide range of psychological problems within the community. Naturally, parents are prone to being anxious about their children amidst this pandemic. This becomes particularly serious when their children are being affected and hospitalized due to exposure to COVID-19, leading to increased anxiety and depression. Our study aims to assess the level of anxiety and depression and the predictor factors for depression and anxiety among the parents of hospitalized COVID-19-infected children. Method: This cross-sectional study incorporated 160 parents of COVID-19 infected children who were admitted to Mugda Medical College Hospital, Dhaka Shishu (Children) Hospital, and Kurmitola General Hospital between April 2020 and October 2020. Result: The study has revealed that among the 160 participants, every one in five parents (19.37%) was suffering from moderate to severe anxiety, while 43.10% of parents were suffering from moderate and moderately severe depression. More than fifty per cent of the respondents were suffering from minimal anxiety (54.38%), while 43.80% of parents were suffering from minimal depression. City dwellers were more prone to developing both anxiety and depression. Conclusion: About 43.1% of parents suffered from moderate and moderately severe depression, while 54.38% of parents suffered from minimal anxiety. These parents need to be addressed, and proper support & intervention must be ensured.
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