Cherubism: A rare case report

Kaur, Manpreet; Shah, Sonali; Babaji, Prashant; Singh, Jaideep; Nair, Divya; Kamble, Suresh S.

doi:10.4103/0976-9668.136283

Cited by 9 publications

(4 citation statements)

References 16 publications

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“…With the enlarged mandible and floating teeth appearance and short stature, cherubism was initially considered as a differential diagnosis. Cherubism [ 15 ] is a childhood disorder characterized by abnormal bone tissue in the lower part of the face. Both upper and lower jaws are enlarged due to the replacement of the bone by cysts.…”

Section: Discussionmentioning

confidence: 99%

Unusually Large Brown tumor of Mandible in a Case of Secondary Hyperparathyroidism Mimicking Cherubism

et al. 2018

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We report here a case of unusually large brown tumor of mandible mimicking cherubism in a patient with secondary hyperparathyroidism (HPT). The patient is a young male with a large head and a protruding jaw with an open mouth appearance. Initial clinical appearance looked like cherubism. However further clinical, biochemical, and radiological evaluation revealed a large brown tumor in a case of prolonged secondary HPT, which was confirmed on histopathology. All of the typical advanced radiological features of HPT were noted, highlighting the severity of progression of the disease. This case emphasizes the need for surveillance of serum calcium levels on routine biochemical investigations as to enable an early diagnosis of HPT. With timely proper management, such cases should be on the decline in the future.

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Section: Discussionmentioning

confidence: 99%

Unusually Large Brown tumor of Mandible in a Case of Secondary Hyperparathyroidism Mimicking Cherubism

et al. 2018

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“…The prevalence in male is 100% when compared with female 50%–70%, i.e., 2:1 ratio. [ 5 ] Two forms exist hereditary (familial) and nonhereditary (nonfamilial). [ 9 ]…”

Section: Discussionmentioning

confidence: 99%

“…Perivascular fibrosis leading to mesenchymal disorder and decreased oxygenation is widely accepted theory for its pathogenesis. [ 5 ]…”

Section: Introductionmentioning

confidence: 99%

Nonfamilial cherubism: A case report and review of literature

Deshmukh

Joshi

Deo

2017

J Oral Maxillofac Pathol

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Cherubism is a rare hereditary developmental condition of the jaws and generally inherited as an autosomal dominant trait. It is also known as familial fibrous dysplasia of the jaws, familial multilocular cystic disease and hereditary fibrous dysplasia of the jaws. The gene for cherubism is mapped to chromosome 4p16.3 may lead to pathologic activation of osteoclasts and disruption of jaw morphogenesis. The lesion usually appears between 2 and 5 years shows a predilection for the mandible and causes a bilateral swelling giving rise to a cherubic chubby appearance. The eosinophilic cuffing of blood vessels appears to be specific for cherubism. The diagnosis is based on clinical, radiographic and histopathologic findings. The purpose of this article is to present a rare case of nonfamilial cherubism as there are very few cases reported and to review the literature with its cone beam computed tomography findings.

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“…Boys are more affected than girls with the proportion of 2 : 1. Although the condition is known to regress spontaneously at puberty, surgical management is sometimes required for cosmetic reasons [1–11]. …”

Section: Introductionmentioning

confidence: 99%

Case Report of Nonfamilial Cherubism in a Toddler: Description of Clinic-Radiographic Features and Osseous-Dental Treatments

Kheir

2016

Case Reports in Medicine

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Cherubism is a rare familial disease that occurs between the ages two and five years and regresses after puberty. Most of the cherubism cases show familial history, but there are some cases without familial histories of disorder. A two-year-old boy with a painless symmetrical progressive swelling of the jaws had visited maxillofacial radiology department. Panoramic radiograph revealed well-defined multilocular, radiolucent areas of both jaws. Computed tomography of the jaws showed well-defined, bilateral, multilocular, expansile lesions with thinning of cortical plate of maxilla and mandible and displacing the unerupted first molar anteriorly. Clinical, radiologic, and histopathologic characteristics confirmed the diagnosis of cherubism.

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Cherubism: A rare case report

Cited by 9 publications

References 16 publications

Unusually Large Brown tumor of Mandible in a Case of Secondary Hyperparathyroidism Mimicking Cherubism

Unusually Large Brown tumor of Mandible in a Case of Secondary Hyperparathyroidism Mimicking Cherubism

Nonfamilial cherubism: A case report and review of literature

Case Report of Nonfamilial Cherubism in a Toddler: Description of Clinic-Radiographic Features and Osseous-Dental Treatments

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