2017
DOI: 10.4103/0973-029x.203791
|View full text |Cite
|
Sign up to set email alerts
|

Nonfamilial cherubism: A case report and review of literature

Abstract: Cherubism is a rare hereditary developmental condition of the jaws and generally inherited as an autosomal dominant trait. It is also known as familial fibrous dysplasia of the jaws, familial multilocular cystic disease and hereditary fibrous dysplasia of the jaws. The gene for cherubism is mapped to chromosome 4p16.3 may lead to pathologic activation of osteoclasts and disruption of jaw morphogenesis. The lesion usually appears between 2 and 5 years shows a predilection for the mandible and causes a bilateral… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
7
0
14

Year Published

2018
2018
2022
2022

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 9 publications
(21 citation statements)
references
References 13 publications
0
7
0
14
Order By: Relevance
“…Clinically, it is presented as a hard and asymptomatic swelling in the affected areas. In addition, submandibular and upper cervical lymphadenopathy has been also reported [23], [45]. Radiographically, it is characterized by bilateral, multilocular radiolucent lesions in the mandible.…”
Section: • Cherubismmentioning
confidence: 99%
See 2 more Smart Citations
“…Clinically, it is presented as a hard and asymptomatic swelling in the affected areas. In addition, submandibular and upper cervical lymphadenopathy has been also reported [23], [45]. Radiographically, it is characterized by bilateral, multilocular radiolucent lesions in the mandible.…”
Section: • Cherubismmentioning
confidence: 99%
“…Cherubism is a rare hereditary non-neoplastic bone lesion that the affects only the jaw bones that typically appears at the age of 2-7 years [45]. There is no sex predilection and the hallmark of cherubism is the development of symmetrical expansile lesions in the mandible and/or the maxilla that begins to regress with the onset of puberty [23].…”
Section: • Cherubismmentioning
confidence: 99%
See 1 more Smart Citation
“…Bone lesions generally start at the angle and ascending ramus of the mandible. Involvements of the mandibular body, coronoid process, and mandibular canal displacement have been also found in some cases [45]. Maxillary involvement is rare and less extensive [23], [45].…”
Section: • Cherubismmentioning
confidence: 99%
“…Cherubism is usually inherited in an autosomal-dominant fashion with variable penetrance (100% in males and 50%-70% in females) and expressivity. However, there are a few reported nonfamilial inheritance cases [8,9] . Mutations in the gene SH3BP2 have been identified as causal of cherubism in most patients [10] .…”
Section: Introductionmentioning
confidence: 99%