Chemotherapy-Induced Peripheral Neuropathy Treated with Dorsal Root Ganglion Stimulation

Groenen, Pauline S.; Helmond, Noud van; Chapman, Kenneth B.

doi:10.1093/pm/pny209

Cited by 14 publications

(16 citation statements)

References 9 publications

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“…Neuromodulation has shown promise in various neuropathic pain states 136 . A number of case reports indicate that neuromodulation may help refractory CIPN 137,138 , but RCT data are lacking.…”

Section: Non-pharmacologicalmentioning

confidence: 99%

Recent advances in understanding chemotherapy-induced peripheral neuropathy

Gordon-Williams

Farquhar-Smith

2020

F1000Res

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Chemotherapy-induced peripheral neuropathy (CIPN) is a common cause of pain and poor quality of life for those undergoing treatment for cancer and those surviving cancer. Many advances have been made in the pre-clinical science; despite this, these findings have not been translated into novel preventative measures and treatments for CIPN. This review aims to give an update on the pre-clinical science, preventative measures, assessment and treatment of CIPN.

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Section: Non-pharmacologicalmentioning

confidence: 99%

Recent advances in understanding chemotherapy-induced peripheral neuropathy

Gordon-Williams

Farquhar-Smith

2020

F1000Res

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“…Central neuropathic pain includes central lesions [ 5 ] and diseases (e.g., stroke [ 6 ], multiple sclerosis [ 7 ]), whereas peripheral nerve injuries or pathological changes induce peripheral neuropathic pain [ 8 ]. Besides, chemotherapy drugs- and diabetes-induced neuropathy are usually classified as peripheral neuropathic pain [ 9 , 10 ]. So far, there has not been enough evidence that interventional management is safe and effective for neuropathic pain.…”

Section: Introductionmentioning

confidence: 99%

Effects of alkaloids on peripheral neuropathic pain: a review

et al. 2020

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Neuropathic pain is a debilitating pathological pain condition with a great therapeutic challenge in clinical practice. Currently used analgesics produce deleterious side effects. Therefore, it is necessary to investigate alternative medicines for neuropathic pain. Chinese herbal medicines have been widely used in treating intractable pain. Compelling evidence revealed that the bioactive alkaloids of Chinese herbal medicines stand out in developing novel drugs for neuropathic pain due to multiple targets and satisfactory efficacy. In this review, we summarize the recent progress in the research of analgesic effects of 20 alkaloids components for peripheral neuropathic pain and highlight the potential underlying molecular mechanisms. We also point out the opportunities and challenges of the current studies and shed light on further in-depth pharmacological and toxicological studies of these bioactive alkaloids. In conclusion, the alkaloids hold broad prospects and have the potentials to be novel drugs for treating neuropathic pain. This review provides a theoretical basis for further applying some alkaloids in clinical trials and developing new drugs of neuropathic pain.

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“…A study indicates that older age, cardiovascular drugs, and preexisting nerve compression syndromes are likely to increase neuropathy risk [7]. Conventional therapy options for CIPN include antidepressants, anticonvulsants, neuromodulation, and physical therapy [8]. A recent RCT proved that sensorimotor training and whole-body vibration training were promising to reduce symptoms [9].…”

Section: Introductionmentioning

confidence: 99%

“…A recent RCT proved that sensorimotor training and whole-body vibration training were promising to reduce symptoms [9]. Clinical reports show dorsal root ganglion (DRG) stimulation may be useful for alleviating the neuropathic pain [8]. There are 15 CIPN-directed clinical trials sponsored by the National Cancer Institute, and it is concluded that alpha-lipoic acid, intravenous calcium/magnesium, vitamin E, or glutathione acts as the prevention, and nortriptyline, gabapentin, lamotrigine, amifostine, or duloxetine acts as symptomatic treatment [10].…”

Section: Introductionmentioning

confidence: 99%

The Method of Activating Blood and Dredging Collaterals for Reducing Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis

Jin

Yan

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Background. Chemotherapy-induced peripheral neuropathy (CIPN) remains as a big unsolved challenge for cancer patients and oncologists. However, there is no effective treatment to prevent and cure it. This systematic review and meta-analysis chiefly aimed to assess the effectiveness and safety on the method of activating blood and dredging collaterals in traditional Chinese medicine (TCM) for reducing CIPN. Methods. Two authors comprehensively searched all the randomized controlled trials (RCTs) via PubMed, Cochrane, China National Knowledge Infrastructure (CNKI), and Wanfang Database of China Science Periodical Database (CSPD). The Review Manager (RevMan) 5.0 was used to conduct the meta-analysis. Results. 20 trials including 1481 participants were analyzed. 15 trials tested the incidence of all-grade CIPN which was significantly lower in intervention arm and 16 trails presented that the result of high-grade CIPN was the same. The total effective rate of the use of Chinese herbs was 77.19% versus 45.79% in the comparator group. Besides, the use of Chinese herbs statistically promoted the sensory nerve conduction velocity (SNCV) and the motor nerve conduction velocity (MNCV). Besides, the quality of life (QoL) in the intervention group was better than the comparator one. Herbs-related adverse events were skin allergy, skin chap, and scald, which could be managed well. Conclusions. The work involving studies of the effectiveness and safety on TCM for reducing CIPN proves to be encouraging. Herbs with the function of activating blood and dredging collaterals were found to potentially promote the curative effects as well as making improvements of SNCV and MNCV. However, in the future, more double-blind, multicenter, large-scale RCTs and more comprehensive researches are still required.

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Chemotherapy-Induced Peripheral Neuropathy Treated with Dorsal Root Ganglion Stimulation

Cited by 14 publications

References 9 publications

Recent advances in understanding chemotherapy-induced peripheral neuropathy

Recent advances in understanding chemotherapy-induced peripheral neuropathy

Effects of alkaloids on peripheral neuropathic pain: a review

The Method of Activating Blood and Dredging Collaterals for Reducing Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis

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