Effects of alkaloids on peripheral neuropathic pain: a review

Zhu, Chunhao; Liu, Ning; Tian, Miaomiao; Ma, Lin; Yang, Jiamei; Lan, Xiao-Bing; Ma, Haijun; Niu, Junfeng; Yu, Jian‐Qiang

doi:10.1186/s13020-020-00387-x

Cited by 16 publications

(13 citation statements)

References 173 publications

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“…These findings corroborate with Gouveia et al (2019) , who demonstrated that compounds belonging to the class of terpenes, alkaloids, flavonoids and cannabinoids have been the target of recent studies on their effects on cancer pain. In fact, the analgesic properties of compounds belonging to these classes of natural products have been extensively demonstrated in several studies, due to their ability to modulate neurotransmission systems, inflammatory response and redox imbalance ( Guimarães et al, 2014 ; Gouveia et al, 2018 ; Ferraz et al, 2020 ; Zhu et al, 2020 ; Anand et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

Antinociceptive effect of plant-based natural products in chemotherapy-induced peripheral neuropathies: A systematic review

et al. 2022

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Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most prevalent and difficult-to-treat symptoms in cancer patients. For this reason, the explore for unused helpful choices able of filling these impediments is essential. Natural products from plants stand out as a valuable source of therapeutic agents, being options for the treatment of this growing public health problem. Therefore, the objective of this study was to report the effects of natural products from plants and the mechanisms of action involved in the reduction of neuropathy caused by chemotherapy. The search was performed in PubMed, Scopus and Web of Science in March/2021. Two reviewers independently selected the articles and extracted data on characteristics, methods, study results and methodological quality (SYRCLE). Twenty-two studies were selected, describing the potential effect of 22 different phytochemicals in the treatment of CIPN, with emphasis on terpenes, flavonoids and alkaloids. The effect of these compounds was demonstrated in different experimental protocols, with several action targets being proposed, such as modulation of inflammatory mediators and reduction of oxidative stress. The studies demonstrated a predominance of the risk of uncertain bias for randomization, baseline characteristics and concealment of the experimental groups. Our findings suggest a potential antinociceptive effect of natural products from plants on CIPN, probably acting in several places of action, being strategic for the development of new therapeutic options for this multifactorial condition.

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Section: Resultsmentioning

confidence: 99%

Antinociceptive effect of plant-based natural products in chemotherapy-induced peripheral neuropathies: A systematic review

et al. 2022

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“…These drugs, however, also have some adverse effects, such as drowsiness, edema, ataxia, vertigo, and so on (Onakpoya et al, 2019). Natural alkaloids have a wide range of targets and good efficacy in peripheral neuropathic pain, which provides a new way for natural alkaloids to relieve central neuropathic pain (Zhu et al, 2020).…”

Section: Effects Of Alkaloids On Central Nervous Painmentioning

confidence: 99%

Research progress of plant‐derived natural alkaloids in central nervous system diseases

Zhang

Jiang

et al. 2023

Phytotherapy Research

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Central nervous system (CNS) disease is one of the most important causes of human death. Because of their complex pathogenesis, more and more attention has been paid to them. At present, drug treatment of the CNS is the main means; however, most drugs only relieve symptoms, and some have certain toxicity and side effects. Natural compounds derived from plants can provide safer and more effective alternatives. Alkaloids are common nitrogenous basic organic compounds found in nature, which exist widely in many kinds of plants and have unique application value in modern medicine. For example, Galantamine and Huperzine A from medicinal plants are widely used drugs on the market to treat Alzheimer's disease. Therefore, the main purpose of this review is to provide the available information on natural alkaloids with the activity of treating central nervous system diseases in order to explore the trends and perspectives for the further study of central nervous system drugs. In this paper, 120 alkaloids with the potential effect of treating central nervous system diseases are summarized from the aspects of sources, structure types, mechanism of action and structure–activity relationship.

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“…For example, indole alkaloids have structural similarities to serotonin, so they are potential sources of anti-depressant drugs [176]. Alkaloids can also impact signal transduction in neurons, and can reduce pain by altering the activity of voltage-gated sodium channels [177]. Other alkaloids intercalate or alkylate DNA, or interfere with protein synthesis or the cytoskeleton, actions that often trigger apoptosis [174].…”

Section: Alkaloidsmentioning

confidence: 99%

From Foods to Chemotherapeutics: The Antioxidant Potential of Dietary Phytochemicals

Briggs

2022

Processes

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Food plants have been recognized for their medicinal properties for millennia, a concept supported by epidemiological studies indicating long-term health benefits for people consuming greater amounts of fruits and vegetables. As our technology and instrumentation advance, researchers have the ability to identify promising phytochemicals, and examine their potential benefits, or detriments, to human health. While results from trials investigating single chemical supplementation have sometimes produced negative health results, studies investigating the synergistic action of phytochemicals—either within our diet or as an adjuvant to radiation or chemotherapy—appear promising. Utilizing phytochemicals as synergistic agents may lower the chemotherapeutic doses needed to incur physiological results, while also using chemicals with fewer toxic effects. This review investigates a variety of plant-produced chemicals humans typically ingest, their impacts on overall health patterns, molecular mechanisms associated with their health impacts, and the potential of their synergistic use for therapeutic purposes.

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Effects of alkaloids on peripheral neuropathic pain: a review

Cited by 16 publications

References 173 publications

Antinociceptive effect of plant-based natural products in chemotherapy-induced peripheral neuropathies: A systematic review

Antinociceptive effect of plant-based natural products in chemotherapy-induced peripheral neuropathies: A systematic review

Research progress of plant‐derived natural alkaloids in central nervous system diseases

From Foods to Chemotherapeutics: The Antioxidant Potential of Dietary Phytochemicals

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