Chemotherapy-induced alopecia

Chon, Susan Y.; Champion, Rachel W.; Geddes, Elizabeth R.; Rashid, Rashid M.

doi:10.1016/j.jaad.2011.02.026

Cited by 121 publications

(129 citation statements)

References 57 publications

(66 reference statements)

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“…While a small area of HOCl-treated irradiated skin developed an intact scar, most of the HOCl-treated irradiated skin showed hair regrowth, indicating that intact hair follicles were maintained in the irradiated skin area (Supplemental Figure 4). This is consistent with the phenomenon of anagen effluvium, which is described in patients following radiation or chemotherapy treatment (33,34). Overall, HOCl-treated animals had significantly reduced RTOG scores across the time course, with scores of 1.8 ± 0.24 and 4.0 ± 0 with and without HOCl treatment, respectively, by day 30 ( Figure 4C).…”

Section: Hocl Reversibly Inhibits Tnf-α-stimulated Nf-κb-dependent Gesupporting

confidence: 86%

Topical hypochlorite ameliorates NF-κB–mediated skin diseases in mice

Leung¹,

Zhang²,

Wang³

et al. 2013

J. Clin. Invest.

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Section: Hocl Reversibly Inhibits Tnf-α-stimulated Nf-κb-dependent Gesupporting

confidence: 86%

Topical hypochlorite ameliorates NF-κB–mediated skin diseases in mice

Leung¹,

Zhang²,

Wang³

et al. 2013

J. Clin. Invest.

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“…However, paclitaxel also affects other normal cell and then occurs a lot of side effects (Chon et al 2012). Especially, paclitaxel-induced hair loss, one of the paclitaxel side effects, is caused by the apoptotic damage in HDP cells, one of the key players to form hair follicle and grow hair (Chen et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Epigallocatechin-3-gallate inhibits paclitaxel-induced apoptosis through the alteration of microRNA expression in human dermal papilla cells

Shin

Jun

Kim³

et al. 2018

biomed dermatol

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Background: Paclitaxel well known as anti-cancer drug has been shown to cause alopecia in chemotherapy. The paclitaxel chemotherapy-mediated alopecia is induced by apoptotic damage in human dermal papilla (HDP) cells. Epigallocatechin-3-gallate (EGCG) inhibits apoptosis against anti-cancer drug such as cisplatin. EGCG, one of the green tea extract ingredients, has been reported to enhance cell viability and to inhibit apoptosis. However, it is unclear that EGCG enhances cell viability and inhibits apoptosis against paclitaxel-induced apoptotic damage in HDP cells. Methods: We show cell viability, cell cycle, and microRNA (miRNA) expression in EGCG-mediated rescue cell to paclitaxel-mediated cell death and growth arrest. Results: EGCG promotes cell survival and cell death inhibitory effects and alteration of miRNA expression in paclitaxelexposed HDP cells were investigated. Firstly, paclitaxel increases apoptosis and EGCG promotes cell survival and represses paclitaxel-induced apoptosis in a dose-dependent manner. Fluorescence-activated cell sorting (FACS) analysis showed that EGCG protects apoptosis in paclitaxel-exposed HDP cells. miRNA microarray analysis was performed and 48 miRNAs changed by EGCG in paclitaxel-exposed HDP cells were identified. In gene ontology analysis in silico, miRNAs regulate apoptosis and cell proliferation-regulated genes, such as BCL2L1, BCL2L2, BBC3, and MDM2. In Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, miRNAs are related to mitogen-activated protein kinase (MAPK) signaling pathway and Wnt signaling pathway, which regulate apoptosis and cell proliferation. Conclusions: EGCG inhibits apoptosis through regulating miRNA expression related to apoptosis and cell proliferation in paclitaxel-treated HDP cells.

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“…1 Permanent chemotherapy-induced alopecia (PCIA) is uncommon, 1 and has primarily been reported with busulfan and high-dose cyclophosphamide conditioning regimens, given before bone marrow transplantation. 2 Nevertheless, cases of PCIA after taxane chemotherapy protocols for breast cancer have been recently described, [3][4][5] showing that permanent alopecia is not solely linked to high-dose chemotherapy regimens.…”

Section: Introductionmentioning

confidence: 99%

Alopécia Permanente Pós-Quimioterapia com Resposta Favorável ao Minoxidil Tópico

Pires

Pinheiro

Lencastre

2018

SPDV

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RESUMO -A alopécia permanente pós-quimioterapia é um efeito adverso raro, classicamente associada a altas doses de quimioterapia sistémica com busulfan para transplante de medula óssea. Recentemente têm sido descritos casos de alopécia permanente pós-quimioterapia em doentes submetidos a quimioterapia sistémica com taxanos no carcinoma da mama. Na revisão da literatura não existem orientações terapêuticas consistentes para esta entidade com impacto importante na qualidade de vida dos doentes. Descreve-se o caso de uma doente de 38 anos que desenvolveu alopecia inaugural e permanente após quimioterapia com taxanos (docetaxel) para carcinoma da mama, com 2 anos de evolução à data da observação. Após 6 meses de tratamento tópico com solução de minoxidil 5%, em regime bidiário, assistiu-se a resposta clínica favorável. Os autores revêm o provável mecanismo patológico da alopécia permanente pós-quimioterapia, bem como os efeitos do minoxidil tópico no ciclo do cabelo, por forma a sustentar este fármaco como opção terapêutica a considerar neste tipo de alopecia. PALAVRAS-CHAVE -Alopecia/induzida quimicamente; Alopecia/tratamento Minoxidil; Taxanos. Case of Permanent Chemotherapy-Induced Alopecia with Response to Topical Minoxidil ABSTRACT -Permanent chemotherapy-induced alopecia is uncommon and has primarily been reported after high-dose busulfan

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Chemotherapy-induced alopecia

Cited by 121 publications

References 57 publications

Topical hypochlorite ameliorates NF-κB–mediated skin diseases in mice

Topical hypochlorite ameliorates NF-κB–mediated skin diseases in mice

Epigallocatechin-3-gallate inhibits paclitaxel-induced apoptosis through the alteration of microRNA expression in human dermal papilla cells

Alopécia Permanente Pós-Quimioterapia com Resposta Favorável ao Minoxidil Tópico

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