Chemoradiotherapy for locally advanced cervix cancer without aortic lymph node involvement: can we consider metabolic parameters of pretherapeutic FDG-PET/CT for treatment tailoring?

Voglimacci, M; Gabiache, Erwan; Lusque, Amélie; Ferron, Gwénaël; Ducassou, A.; Querleu, Denis; Motton, Stéphanie; Chantalat, Élodie; Courbon, F.; Martinez, Alejandra

doi:10.1007/s00259-018-4219-5

Cited by 18 publications

(18 citation statements)

References 47 publications

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“…Similar findings were available in the mantle cell lymphoma (27). However, Voglimacci et al (28) found that higher cervical SUV max and TLG were significantly associated with poor response to chemoradiotherapy. Nakajo et al (29) reported that the positive and negative predictive values for non-responders in esophageal cancer treated by chemoradiotherapy were 77 and 69% in MTV and 76 and 100% in TLG, respectively.…”

Section: Discussionsupporting

confidence: 64%

Utility of [18F] Fluoro-Deoxyglucose Positron Emission Tomography/Computed Tomography for Staging and Therapy Response Evaluation in Pediatric Rhabdomyosarcoma: A Case Series and Literature Review

Liu

Zhao

et al. 2020

Front. Med.

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Background: The role of [ 18 F] fluoro-deoxyglucose [[ 18 F] FDG] positron emission tomography (PET)/computed tomography (CT) in pediatric rhabdomyosarcoma (RMS) is not well-established. This manuscript explores the role of staging and therapy response evaluation of PET/CT in a series of patients with RMS. Methods: Thirteen consecutive patients with pathologically proven RMS underwent baseline PET/CT scan and a second PET/CT for evaluation of therapy response. Maximum standardized uptake value (SUV max), mean standardized uptake value (SUV mean), highest standardized uptake peak value (SUV peak), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were obtained from baseline PET/CT and were used as potential predictors for evaluation of metabolic treatment response. Results: On baseline PET/CT, most RMSs are located in the pelvic cavity, and upper arms ranked second. The primary lesions were large and showed invasion to the surrounding tissues. Lymph node metastases were seen in eight patients, and eight patients showed distant metastasis to the lung, liver, and bone. The median SUV max , SUV mean , and SUV peak of primary sites were 7.1, 4.0, and 5.9, respectively. The median MTV and TLG were 196.6 cm 3 and 780.2, respectively. After therapy, six patients received complete metabolic response (CMR) and non-CMR occurred in seven patients on the second PET/CT. SUV max , SUV peak , MTV, and TLG in patients with CMR were significantly lower than those in patients with non-CMR. Conclusions: Primary sites and metastatic lesions of RMS demonstrate increased glycolytic activity, which may allow them to be imaged using [ 18 F] FDG PET/CT. Metabolic parameters derived from the baseline PET/CT have potential value for predicting CMR to therapy in pediatric RMS.

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Section: Discussionsupporting

confidence: 64%

Utility of [18F] Fluoro-Deoxyglucose Positron Emission Tomography/Computed Tomography for Staging and Therapy Response Evaluation in Pediatric Rhabdomyosarcoma: A Case Series and Literature Review

Liu

Zhao

et al. 2020

Front. Med.

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“…Precise diagnosis of early stage CC can raise the five‐year survival ratio and reduce the medical expenses in CC management. Currently, the most common CC screening method includes Pap smears and HPV testing, and imaging tools such as computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) were commonly utilized in making treatment decisions . Compared with imaging and pathological tools, blood tests are of particular interest in cancer screening owing to the easy operation, noninvasive measurement, and fairly low cost .…”

Section: Resultsmentioning

confidence: 99%

Construction of a Plasmonic Chip for Metabolic Analysis in Cervical Cancer Screening and Evaluation

et al. 2019

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There is a high demand for high‐throughput in vitro metabolic analysis in clinical practice. However, current metabolic analysis of biofluids requires tedious sample pretreatment due to sample complexity and low molecular abundance. Herein, a plasmonic chip with Au nanoparticles deposited on a dopamine‐bubble layer is constructed for clinical metabolic fingerprints. The structural parameters of the designed chip are optimized in terms of surface roughness and Au content. The established chip enables fast, sensitive, and selective detection of small metabolites in human serum without any enrichment or purification. On‐chip serum fingerprints further allow for differentiation between women diagnosed with cervical cancer and control subjects, as well as the therapeutic evaluation for potential clinical monitoring. This work boosts the application of laser desorption/ionization mass spectrometry in large‐scale clinical in vitro diagnosis.

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“…SUVmax primary cervical tumour is the most commonly used metabolic parameter in current routine practice and its prognostic benefit in the management of cervical cancers has been extensively described in the literature (17,(25)(26)(27)(28). The prognostic value of primary cervical tumour MTV and TLG has been also investigated in several studies (29)(30)(31)(32)(33).…”

Section: Discussionmentioning

confidence: 99%

¹⁸F-FDG PET/CT Identifies Predictors of Survival in Patients with Locally Advanced Cervical Carcinoma and Paraaortic Lymph Node Involvement to Allow Intensification of Treatment

et al. 2020

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Introduction: To use positron emission tomography coupled with computed tomography (18 FDG-PET/CT) to identify a high-risk subgroup requiring therapeutic intensification among patients with locally advanced cervical cancer (LACC) and para-aortic lymph node (PALN) involvement. Methods: In this retrospective multicentric study, patients with LACC and PALN involvement concurrently treated with chemoradiotherapy and extended-field radiotherapy (EFR) between 2006 and 2016 were included. A senior nuclear medicine specialist in PET for gynaecologic oncology reviewed all 18 FDG-PET/CT scans. Metabolic parameters including maximum standardised uptake value (SUVmax), metabolic tumour volume (MTV) and total lesion glycolysis (TLG) were determined for the primary tumour, pelvic lymph nodes and PALN. Associations between these parameters and overall survival (OS) were assessed with Cox's proportional hazards model. Results: Sixty-eight patients were enrolled in the study. Three-year OS was 55.5% (95% CI [40.8-68.0]). When adjusted for age, stage and histology, pelvic lymph node TLG, PALN TLG and PALN SUVmax were significantly associated with OS (p<0.005). Conclusion: FDG-PET/CT was able to identify predictors of survival in the homogeneous subgroup of patients with LACC and PALN involvement, thus allowing therapeutic intensification to be proposed.

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Chemoradiotherapy for locally advanced cervix cancer without aortic lymph node involvement: can we consider metabolic parameters of pretherapeutic FDG-PET/CT for treatment tailoring?

Cited by 18 publications

References 47 publications

Utility of [18F] Fluoro-Deoxyglucose Positron Emission Tomography/Computed Tomography for Staging and Therapy Response Evaluation in Pediatric Rhabdomyosarcoma: A Case Series and Literature Review

Utility of [18F] Fluoro-Deoxyglucose Positron Emission Tomography/Computed Tomography for Staging and Therapy Response Evaluation in Pediatric Rhabdomyosarcoma: A Case Series and Literature Review

Construction of a Plasmonic Chip for Metabolic Analysis in Cervical Cancer Screening and Evaluation

¹⁸F-FDG PET/CT Identifies Predictors of Survival in Patients with Locally Advanced Cervical Carcinoma and Paraaortic Lymph Node Involvement to Allow Intensification of Treatment

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Chemoradiotherapy for locally advanced cervix cancer without aortic lymph node involvement: can we consider metabolic parameters of pretherapeutic FDG-PET/CT for treatment tailoring?

Cited by 18 publications

References 47 publications

Utility of [18F] Fluoro-Deoxyglucose Positron Emission Tomography/Computed Tomography for Staging and Therapy Response Evaluation in Pediatric Rhabdomyosarcoma: A Case Series and Literature Review

Utility of [18F] Fluoro-Deoxyglucose Positron Emission Tomography/Computed Tomography for Staging and Therapy Response Evaluation in Pediatric Rhabdomyosarcoma: A Case Series and Literature Review

Construction of a Plasmonic Chip for Metabolic Analysis in Cervical Cancer Screening and Evaluation

18F-FDG PET/CT Identifies Predictors of Survival in Patients with Locally Advanced Cervical Carcinoma and Paraaortic Lymph Node Involvement to Allow Intensification of Treatment

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¹⁸F-FDG PET/CT Identifies Predictors of Survival in Patients with Locally Advanced Cervical Carcinoma and Paraaortic Lymph Node Involvement to Allow Intensification of Treatment