Construction of a Plasmonic Chip for Metabolic Analysis in Cervical Cancer Screening and Evaluation

Shu, Weikang; Wang, You; Liu, Chao; Li, Rongxin; Pei, Congcong; Lou, Weihua; Lin, Sihan; Di, Wen; Wan, Jingjing

doi:10.1002/smtd.201900469

Cited by 59 publications

(53 citation statements)

References 49 publications

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“…Plasmonic materials are usually noble metals and afford unique optical properties for diverse biomedical use [15][16][17] . Particularly, nearinfrared fluorescence enhanced (NIR-FE, the wavelength of 650-1700 nm) detection promises the state-of-the-art in vivo imaging and in vitro diagnosis, through a series of pre-selected materials interfaces [18][19][20] . For example, given characteristic gold nanoislands and immobilized immunoassays on the surface, plasmonic gold nano-island (pGold) chips afford NIR-FE detection of target molecules by high-performance microarrays 21 .…”

mentioning

confidence: 99%

Diagnosis and prognosis of myocardial infarction on a plasmonic chip

Wang

Dai

et al. 2020

Nat Commun

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Cardiovascular diseases lead to 31.5% of deaths globally, and particularly myocardial infarction (MI) results in 7.4 million deaths per year. Diagnosis of MI and monitoring for prognostic use are critical for clinical management and biomedical research, which require advanced tools with accuracy and speed. Herein, we developed a plasmonic gold nano-island (pGold) chip assay for diagnosis and monitoring of MI. On-chip microarray analysis of serum biomarkers (e.g., cardiac troponin I) afforded up to 130-fold enhancement of near-infrared fluorescence for ultra-sensitive and quantitative detection within controlled periods, using 10 μL of serum only. The pGold chip assay achieved MI diagnostic sensitivity of 100% and specificity of 95.54%, superior to the standard chemiluminescence immunoassay in cardiovascular clinics. Further, we monitored biomarker concentrations regarding percutaneous coronary intervention for prognostic purpose. Our work demonstrated a designed approach using plasmonic materials for enhanced diagnosis and monitoring for prognostic use towards point-of-care testing.

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confidence: 99%

Diagnosis and prognosis of myocardial infarction on a plasmonic chip

Wang

Dai

et al. 2020

Nat Commun

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“…A multifunctional platinum nanoreactor intended for point-of-care metabolic analysis, visual detection, and mass spectrometry fingerprinting for in vitro pancreatic cancer diagnostics was designed using controlled core-shell structured Fe 3 O 4 @SiO 2 @Pt particles [157]. Another work describing the application of laser desorption/ionization mass spectrometry in large-scale clinical in vitro cervical cancer diagnosis utilized a plasmonic chip with Au nanoparticles deposited on a dopamine bubble layer [158].…”

Section: Advances In Plasmonic Nanomaterialsmentioning

confidence: 99%

Smart Nanomaterials for Biomedical Applications—A Review

Aflori¹

2021

Nanomaterials

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Recent advances in nanotechnology have forced the obtaining of new materials with multiple functionalities. Due to their reduced dimensions, nanomaterials exhibit outstanding physio-chemical functionalities: increased absorption and reactivity, higher surface area, molar extinction coefficients, tunable plasmonic properties, quantum effects, and magnetic and photo properties. However, in the biomedical field, it is still difficult to use tools made of nanomaterials for better therapeutics due to their limitations (including non-biocompatible, poor photostabilities, low targeting capacity, rapid renal clearance, side effects on other organs, insufficient cellular uptake, and small blood retention), so other types with controlled abilities must be developed, called “smart” nanomaterials. In this context, the modern scientific community developed a kind of nanomaterial which undergoes large reversible changes in its physical, chemical, or biological properties as a consequence of small environmental variations. This systematic mini-review is intended to provide an overview of the newest research on nanosized materials responding to various stimuli, including their up-to-date application in the biomedical field.

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“…Thirdly, it requires an excellent light absorption at the MS laser wavelength (e. g., 337 nm, 355 nm), which can better absorb the laser energy and transfer it to the analyte [18a] . Last but not least, the substrate‘s surface structure needs to be carefully optimized to capture small molecules selectively [14b] . The segments with these features can be integrated into one composite matrix, offering distinct advantages than conventional single matrix materials.…”

Section: Ldi Mechanismmentioning

confidence: 99%

“…This work initiated the design of nanomaterials based matrix for advanced metabolic analysis toward precision diagnosis. In addition to using silicon and graphene to compound with gold, our research group recently reported a simple method to synthesis the plasmonic chip with Au nanoparticles deposited on a dopamine‐bubble layer for clinical metabolic fingerprints [14b] . By optimizing the surface roughness and Au content, the hybrid chips enabled fast, sensitive, and selective detection of small metabolites in serum without any pretreatment.…”

Section: Nanocomposites and Their Applicationmentioning

confidence: 99%

“…Despite substantial progress in matrix material design, the matrix performance of these materials with single structure and simple morphology is far from ideal when applied in complex systems. In parallel, composite nanomaterials have received intense interest from research groups globally due to their multi‐function and high ionization efficiency [14b,18] . Composite materials with synergistic effects can overcome the defects of single materials, and meet the increasing analysis requirements for rapid, selective and sensitive detection of small molecules in complex samples [19] .…”

Section: Introductionmentioning

confidence: 99%

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Nanocomposite‐Based Matrices in Laser Desorption/Ionization Mass Spectrometry for Small‐Molecule Analysis

Pei

Wan

2020

ChemPlusChem

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The efficient detection of small molecules is of significance for environmental monitoring, pharmacology, metabolomics, and lipidomics. The laser desorption/ionization mass spectrometry (LDI MS) platform enables high sensitivity, accuracy, resolution, and throughput in molecular analysis, but its analytical capability with respect to small molecules is limited due to inherent drawbacks arising from conventional organic matrices. The selection of an appropriate matrix is thus a precondition for small molecule detection by LDI MS. To date, various inorganic matrices have been developed, with a growing interest in composite materials displaying synergetic effects. This Minireview highlights the development of nanocomposites as LDI matrices driven by numerous innovations in material science, and their emerging use in small-molecule analysis.

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Construction of a Plasmonic Chip for Metabolic Analysis in Cervical Cancer Screening and Evaluation

Cited by 59 publications

References 49 publications

Diagnosis and prognosis of myocardial infarction on a plasmonic chip

Diagnosis and prognosis of myocardial infarction on a plasmonic chip

Smart Nanomaterials for Biomedical Applications—A Review

Nanocomposite‐Based Matrices in Laser Desorption/Ionization Mass Spectrometry for Small‐Molecule Analysis

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