Chemoprotective effect of vitamin E in cyclophosphamide-induced hepatotoxicity in rats

Cüce, Gökhan; Çetinkaya, Seda; Koc, Tugba; Esen, Hacı Hasan; Limandal, Cisem; Balcı, Tevfik; Kalkan, Serpil; Aköz, Mehmet

doi:10.1016/j.cbi.2015.02.016

Cited by 60 publications

(41 citation statements)

References 26 publications

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“…Caspase-3, the main apoptotic executioner, causes chromatin condensation, protein breakdown, and DNA fragmentation (D'Amelio et al, 2010). In agreement with the present results, earlier investigations revealed that CYP induced liver tissue apoptosis (Cuce et al, 2015), and PNG had an antiapoptotic effect (Yaidikar and Thakur, 2015). The anti-apoptotic activity of PNG is mostly a reflection of its antioxidant, antiinflammatory, and antinitrosative properties.…”

Section: Discussionsupporting

confidence: 90%

“…PNG yellow powder, chemical formula: C 48 H 28 O 30, water insoluble, purity ≥98%, purchased from Sigma-Aldrich, USA, and prepared as suspension in 1% Tween 80 (T80). In this work, the doses depended on our preliminary experimental work, and were in consistence with prior investigations (Cuce et al, 2015;Yaidikar and Thakur, 2015).…”

Section: Drugsmentioning

confidence: 89%

“…Earlier studies showed that CYP increased ROS generation, peroxidation of biological membranes, and MDA production, and depleted natural antioxidant defenses of liver tissue (Germoush and Mahmoud, 2014;Cuce et al, 2015). Oxidative stress initiates inflammatory response and increases production of inflammatory cytokines, as TNF-␣ and IL-1␤.…”

Section: Discussionmentioning

confidence: 99%

“…Necrosis and apoptosis of liver tissue eventually occur. The use of antioxidative and anti-inflammatory agents proved effective against CYP-induced hepatotoxicity in previous studies (Cuce et al, 2015;Nafees et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Punicalagin alleviates hepatotoxicity in rats challenged with cyclophosphamide

Fouad

Qutub

Al-Melhim

2016

Environmental Toxicology and Pharmacology

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Section: Discussionsupporting

confidence: 90%

Section: Drugsmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Punicalagin alleviates hepatotoxicity in rats challenged with cyclophosphamide

Fouad

Qutub

Al-Melhim

2016

Environmental Toxicology and Pharmacology

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“…However, antioxidants protect cells against DNA damage because they are able to sequester free radicals [38]. In addition, these free radicals can regulate DNA in order to repair enzymes, and posttranscriptional factors [19].…”

Section: Discussionmentioning

confidence: 99%

Ascorbic acid modulates doxorubicin and cyclophosphamide-induced cytogenetic damages in Sarcoma 180 cells

Alencar¹,

Islam²,

Rocha³

et al. 2016

Int Arch Med

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Cancer is a public health global problem. Cyclophosphamide (CPA) and Doxorubicin (DOX) are used in chemotherapy, especially by generating reactive oxygen species. The clinical use of ascorbic acid during chemotherapy also raises several controversies due to its antagonistic effects on antineoplastic agent. In this sense, this study aims to evaluate the effects of ascorbic acid (2 µg/mL) on the modulation of cytogenetic damage induced by CPA (20 µg/mL) and DOX (2 µg/ mL), as well as their interaction (AC protocol) on Sarcoma 180 tumor cells. Cytogenetic damage classified as apoptosis, necrosis, micronuclei, buds and nucleoplasmic bridges were linked to the CytokinesisBlock Micronucleus Assay application. CPA and DOX induce significant (p<0.05) increases in apoptosis, necrosis and micronuclei in the cell types tested. The damage on Sarcoma 180 cells was modulated by ascorbic acid with percentage modulation in more than 70% of CPA relative to apoptosis and micronuclei, and 32% to necrosis. The damage of DOX has been modulated by 70% to apoptosis, 40% to necrosis, rather than micronuclei, whereas, in AC protocol, modulations were observed by 52% to apoptosis and 32% and 40% to necrosis and micronuclei, respectively. There was no significance in relation to the nuclear buds and nucleoplasmic bridges. In addition, ascorbic acid did not show any effect. These results are other studies, which indicate hazards to chemotherapy effectiveness due to the antioxidant effects

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Antinociceptive, Anti‐Hyperalgesia and Antiallodynic Activities of Polyphenol Rich Extract fromShorea roxburghiiagainst Cyclophosphamide Induced Peripheral Neuropathy

Wang

Olatunji

Xue

2021

Chemistry & Biodiversity

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Cyclophosphamide (CYP) is a widely used antineoplastic and immunosuppressive drug, however, despite its efficacy, it has shown extensive multiple organ toxicities, including peripheral neuropathy which significantly affects the quality of life of cancer patients. This study elucidated the protective properties of Shorea roxburghii polyphenol extract (SLPE) in CYP‐induced peripheral neuropathy. Rats were treated with SLPE (100 and 400 mg/kg) for five weeks plus CYP once a week from the second week of SLPE treatment. Using UHPLC‐QTOF‐MS, 54 polyphenolic compounds were identified in SLPE extract. After the treatment period the antinociceptive, anti‐hyperalgesia and antiallodynic effects was evaluated using formalin paw edema, acetic acid abdominal writhing, hot plate, tail immersion and von Frey filament tests. While the locomotive and motor coordination effects were evaluated by open field and rotarod tests. The administration of CYP led to significant increases in mechanical and thermal hyperalgesia, in addition to hyper‐nociceptive responses in the formalin and acetic acid writhing tests. CYP also significantly reduced locomotive activity and motor coordination. SLPE significantly protected against CYP‐induced mechanical and thermal hyperalgesia. Furthermore, SLPE displayed robust antinociceptive effect by counteracting formalin and acetic acid induced hyper‐nociception. In addition, SLPE increased the locomotive activity as well as the grip and motor coordination of the CYP treated rats. In conclusion, these results revealed the protective effects of SLPE against CYP‐induced peripheral neuropathy and could be an effective therapeutic remedy for chemotherapy induced peripheral neuropathy.

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Chemoprotective effect of vitamin E in cyclophosphamide-induced hepatotoxicity in rats

Cited by 60 publications

References 26 publications

Punicalagin alleviates hepatotoxicity in rats challenged with cyclophosphamide

Punicalagin alleviates hepatotoxicity in rats challenged with cyclophosphamide

Ascorbic acid modulates doxorubicin and cyclophosphamide-induced cytogenetic damages in Sarcoma 180 cells

Antinociceptive, Anti‐Hyperalgesia and Antiallodynic Activities of Polyphenol Rich Extract fromShorea roxburghiiagainst Cyclophosphamide Induced Peripheral Neuropathy

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