Punicalagin alleviates hepatotoxicity in rats challenged with cyclophosphamide

Fouad, Amr A.; Qutub, Hatem; Al-Melhim, Walid N.

doi:10.1016/j.etap.2016.05.031

Cited by 53 publications

(50 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In some parts of the CP-injected liver tissues there were small haemorrhage and edema sites, ballooning, vacuolization and hepatocellular necrosis. Similar results were demonstrated in former studies [38,39]. It could be inferred that HT improved the CP-injected cellular damage and inflammation in the livers of rats with its antioxidant and cytoprotective properties.…”

Section: Discussionsupporting

confidence: 90%

A Histopathological, Immunohistochemical and Biochemical Investigation on the in vitro Antioxidant, Myeloprotective, Hematoprotective and Hepatoprotective Effects of Hypericum triquetrifolium Seed Extract Against Cyclophosphamide-Induced Toxicity

Yıldız

Keskin

Şahıntürk

et al. 2019

Braz. arch. biol. technol.

View full text Add to dashboard Cite

The aim of this study was to investigate in vitro antioxidant properties and in vivo protective effects of the methanol extract of the Hypericum triquetrifolium Turra (HT) seed against acute hepatotoxicity, myelotoxicity and hematotoxicity in rats induced by cyclophosphamide (CP). In order to investigate in vivo protective effects of the HT extract on rat tissues, the rats were divided into nine groups. The toxic effects of CP and the protective effects of HT extract on nucleated cells that are produced by bone marrow, serum alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and oxidative stress index (OSI) levels were investigated biochemically. Additionally, liver tissue samples were examined for histopathological changes and apoptosis by Bcl-2, Bax and caspase-3 immunohistochemistry. The results of this study show that HT seed methanol extract has high total phenolic content (179.52 μg GAE/mg) and antioxidant activity (87.48% in 500 μg/mL concentration). CP administration caused hepatotoxicity, myelotoxicity and hematotoxicity in the rats. Whereas, the groups of rats that were injected with different concentrations of HT (25, 50 and 100 mg/kg) and CP (150 mg/kg) showed significant protective effects on bone marrow nucleated cells and important decreases on serum ALT, ALP, LDH and OSI levels were observed when compared with the CP injected group.

show abstract

Section: Discussionsupporting

confidence: 90%

A Histopathological, Immunohistochemical and Biochemical Investigation on the in vitro Antioxidant, Myeloprotective, Hematoprotective and Hepatoprotective Effects of Hypericum triquetrifolium Seed Extract Against Cyclophosphamide-Induced Toxicity

Yıldız

Keskin

Şahıntürk

et al. 2019

Braz. arch. biol. technol.

View full text Add to dashboard Cite

show abstract

“…Unlikely, Ran which reduced these alterations without normalization indicating the superior antioxidant property of PCG to the standard drug; Ran. Previous studies also displayed the antioxidant property of PCG [11,12,[23][24][25].…”

mentioning

confidence: 84%

“…It has strong antioxidant, chemopreventive effect and angiogenic activities in addition to its beneficial effects in attention of prostate cancer cell growth, management of diabetes, myocardial ischemia reperfusion injury, and liver toxicity, tissue repairing and wound healing [6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective Effect of Punicalagin against Ethanol-Induced Gastric Ulcer: The Possible Underlying Mechanisms

Mohamed¹,

Salahuddin²

2017

Biomark J

View full text Add to dashboard Cite

Gastric ulcer is the most digestive disease found in clinical practice. Punicalagin (PCG) found in pomegranate juice has antioxidant and tissue repair properties. Therefore, the aim of this study was to investigate punicalagin's gastroprotective effect against ethanol-induce gastric injury. Four groups of rats; first group served as control, group 2: Treated with absolute ethanol (5 ml/kg, po), group 3: Rats were pre-treated with ranitidine (as a reference drug) (50 mg/kg, po) before ethanol and group 4: Pre-treated with PCG (4 mg/kg, po) before ethanol. Pretreatment with PCG reduced ulcer index and histopathological changes, oxidative stress induced by ethanol while it elevated antioxidant activity. Although, it down regulated Tumor Necrosis Factor (TNF-α) gene expression and mucosal levels of inflammatory cytokines; TNF-α, Interleukin (IL-1β) and Interferon Gamma (IFNγ), it up regulated mucosal level of IL-10. Also, it reduced mucosal Nuclear Factor Kappa B (NFκB) protein expression, mylopeoxidase and caspase 3 activities as well as gene expression of caspase 9 while it elevated antiapoptotic B-Cell Lymphoma 2 (Bcl-2) gene expression, mucosal nitric oxide and mucin content. However, it had negative action on prostaglandin E2 and acid secretions. These findings indicate gastroprotective effects of punicalagin against ethanol induced gastric ulcer through suppression of mucosal oxidative stress and inflammation through NFκB pathway as well cytoprotective defences independent on prostaglandin E2 and acid secretions.

show abstract

“…Respect to the histopathological findings, in the groups co-treated with HP and Liv 52 showed similar architecture to the healthy group. The authors concluded that the use of HP effectively protects hepatic cells, which may be due to the presence of active antioxidant ingredients, such as fillantin, hypofillantin, withaferin, amber and curcumin, among others, which are present in the polyherbal formula [70][71][72][73] Punicalagin (ellagitannin, isolated from Punica granatum), showed a protector effect against the CCl 4 , acetaminophen and cyclophosphamide damage, but its effect against anti-TB drugs has not been reported [88]. The protector effect of ursodeoxycholic acid (UDCA at 15, and 150 mg/kg) was analyzed against liver harm caused by INH/RIF (75 and 150 mg/kg) in female CD-1 mice during a week.…”

Section: Pre-clinical Evaluationmentioning

confidence: 99%

Hepato-Protective Effect from Natural Compounds, Biological Products and Medicinal Plant Extracts on Antitubercular Drug-Induced Liver Injuries: A Systematic Review

Ramírez-Marroquín¹,

Jiménez-Arellanes²

2019

Med Aromat Plants

View full text Add to dashboard Cite

Tuberculosis is mainly treated with rifampicin, pyrazinamide, isoniazide, ethambutol and/or streptomycin; however, the first three cause hepato-and nephro-toxicity, then the patient abandons therapy. This cause contributes to the failure of the treatment and favors the appearance of drug-resistant strains. Currently, alternatives are being sought to counteract this hepatic-damage, and medicinal plants, natural compounds and/or biological products are of great interest. In this manuscript we describe current data on the hepato-protective effect from extracts of medicinal plants, compounds isolated from them and biological products that protect against liver damage caused by antitubercular (anti-TB) drugs caused by therapy in patients with tuberculosis (TB). The main consulted databases were: PubMed, Worldwidescience.org, and Scopus, including records between 2000 and 2018 years. Thus, we found many articles about hepatoprotective effect from medicinal plants and polyherbal preparations (Hepatoplus and Liv 52), the majority of these have an important effect (on preclinical study) due to their antioxidant compounds content. In addition, the hepatoprotective activity of biological products and/or natural compounds has been discussed and it should be noted that the quercetin (natural antioxidant compound)/ polyvinylpyrrolidone mixture protects against hepatic damage caused by therapy in patients with TB. Another interesting compound with good effect in TB patients is N-acetylcysteine (an oral marketed mucolytic drug) which could be repurposed as an hepatoprotective drug. We consider that these findings are of great interest for researchers and clinicians, also for the development of new agents as well as for the therapeutic use of hepatoprotective substances in patients with TB, which helps reduce the toxic effects that drugs cause.

show abstract

Punicalagin alleviates hepatotoxicity in rats challenged with cyclophosphamide

Cited by 53 publications

References 18 publications

A Histopathological, Immunohistochemical and Biochemical Investigation on the in vitro Antioxidant, Myeloprotective, Hematoprotective and Hepatoprotective Effects of Hypericum triquetrifolium Seed Extract Against Cyclophosphamide-Induced Toxicity

A Histopathological, Immunohistochemical and Biochemical Investigation on the in vitro Antioxidant, Myeloprotective, Hematoprotective and Hepatoprotective Effects of Hypericum triquetrifolium Seed Extract Against Cyclophosphamide-Induced Toxicity

Gastroprotective Effect of Punicalagin against Ethanol-Induced Gastric Ulcer: The Possible Underlying Mechanisms

Hepato-Protective Effect from Natural Compounds, Biological Products and Medicinal Plant Extracts on Antitubercular Drug-Induced Liver Injuries: A Systematic Review

Contact Info

Product

Resources

About