Chemoprotective Effect of<i>Phyllanthus maderaspatensis</i>. in Modulating Cisplatin-Induced Nephrotoxicity and Genotoxicity

Chandrasekar, M; Bommu, Praveen; Nanjan, M. J.; Suresh, B.

doi:10.1080/13880200600592046

Cited by 23 publications

(18 citation statements)

References 25 publications

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“…Herbs contain free radical scavengers like polyphenols, flavonoids and phenolic compounds. A number of scientific reports indicate certain terpenoids, steroids and phenolic compounds such as tannins, coumarins and flavonoids have protective effects due to its antioxidant properties [61]. Phenolics are the most wide spread secondary metabolite in plant kingdom.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Activity and Total Phenolic Content of Moringa oleifera Leaves in Two Stages of Maturity

Sreelatha

Padma

2009

Plant Foods Hum Nutr

503

316

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Antioxidants play an important role in inhibiting and scavenging free radicals, thus providing protection to human against infections and degenerative diseases. Current research is now directed towards natural antioxidants originated from plants due to safe therapeutics. Moringa oleifera is used in Indian traditional medicine for a wide range of various ailments. To understand the mechanism of pharmacological actions, antioxidant properties of the Moringa oleifera leaf extracts were tested in two stages of maturity using standard in vitro models. The successive aqueous extract of Moringa oleifera exhibited strong scavenging effect on 2, 2-diphenyl-2-picryl hydrazyl (DPPH) free radical, superoxide, nitric oxide radical and inhibition of lipid per oxidation. The free radical scavenging effect of Moringa oleifera leaf extract was comparable with that of the reference antioxidants. The data obtained in the present study suggests that the extracts of Moringa oleifera both mature and tender leaves have potent antioxidant activity against free radicals, prevent oxidative damage to major biomolecules and afford significant protection against oxidative damage.

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Section: Discussionmentioning

confidence: 99%

Antioxidant Activity and Total Phenolic Content of Moringa oleifera Leaves in Two Stages of Maturity

Sreelatha

Padma

2009

Plant Foods Hum Nutr

503

316

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“…Free radical scavengers may include polyphenols, flavonoids, and phenolic compounds. 29 Moringa oleifera could enhance the anti oxidant system present in the epididymis which in turn preserved and facilitated the process of spermatogenesis. Apparently, it may have reversed concentrations of gonadotropins (FSH and LH) and ultimately testosterone.…”

Section: Discussionmentioning

confidence: 99%

Pre and Post-Treatment Effects: Estimation of Serum Testosterone and Lipid Peroxidation Levels on Moringa olifera Extract Induced Cadmium Exposed Rats

Chatterjee

Anantharaya

Shiva³

et al. 2017

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“…It is known that chemoprotective agents are capable of exerting their antigenotoxic effects by one mechanism or a combination of mechanisms. These mechanisms include the scavenging of ROS, the reducing of formation of reactive carcinogenic-metabolites, the inducing of carcinogen-detoxifying enzymes, the effect on apoptosis and the inhibition of cell proliferation (Premkumar et al 2004;Chandrasekar et al 2006). Meanwhile, gene transcription is directly influenced by antioxidants through the presence of antioxidant response elements in the promoters of many genes (Palmer & Paulson 1997).…”

Section: Antioxidant Activity Of D Glabra Leaves Extract (Dge) Againmentioning

confidence: 99%

Flavonoid constituents of Dobera glabra leaves: amelioration impact against CCl₄-induced changes in the genetic materials in male rats

Elkhateeb¹,

Latif²,

Marzouk³

et al. 2016

Pharmaceutical Biology

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Context: Dobera glabra (Forssk.) Poir (Salvadoraceae) is a highly valued tree with diverse importance as special mineral sourced feed and a folkloric tool for forecasting droughts. However, there are no reports on its phytochemical and biological investigations. Objective: Phytochemical investigation of D. glabra leaves and its protective potential against CCl 4 inducing changes in the genetic materials. Materials and methods: D. glabra extract, DGE (70% MeOH/H 2 O), was applied to polyamide column chromatography, eluting with MeOH/H 2 O of decreasing polarities, followed by preparative chromatographic tools, yielded seven compounds. Three DGE doses (50, 100 and 200 mg/kg bw/d) were administrated for 8 weeks intragastrically to male albino rats prior treated with CCl 4 (0.5 mL/kg/bw). The reactive oxygen species (ROS) levels, expression changes of glutamate transporters (GLAST, GLT-1 and SNAT3) mRNA, DNA fragmentation and glutathione peroxidase (GPx) activity were investigated in the liver tissues of these rats.and kaempferol were identified. DGE (200 mg/kg bw) þ CCl 4 exhibited the most significant reduction in ROS levels and DNA fragmentation with 251.3% and141% compared to 523.1% and 273.2% for CCl 4 , respectively. Additionally, it increased significantly the mRNA expression of GLAST, GLT-1 and SNAT3 to 2.16-, 1.72-and 2.09-fold, respectively. Also, GPx activity was increased to 4.8 U/mg protein/min compared to CCl 4 (1.8 U/mg protein/min). Discussion and conclusion: Flavonoid constituents, antioxidant effect and genotoxic protection activity of D. glabra were first reported. DGE may be valuable in the treatment and hindrance of hepatic oxidative stress and genotoxicity.ARTICLE HISTORY

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Chemoprotective Effect ofPhyllanthus maderaspatensis. in Modulating Cisplatin-Induced Nephrotoxicity and Genotoxicity

Cited by 23 publications

References 25 publications

Antioxidant Activity and Total Phenolic Content of Moringa oleifera Leaves in Two Stages of Maturity

Antioxidant Activity and Total Phenolic Content of Moringa oleifera Leaves in Two Stages of Maturity

Pre and Post-Treatment Effects: Estimation of Serum Testosterone and Lipid Peroxidation Levels on Moringa olifera Extract Induced Cadmium Exposed Rats

Flavonoid constituents of Dobera glabra leaves: amelioration impact against CCl₄-induced changes in the genetic materials in male rats

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Chemoprotective Effect ofPhyllanthus maderaspatensis. in Modulating Cisplatin-Induced Nephrotoxicity and Genotoxicity

Cited by 23 publications

References 25 publications

Antioxidant Activity and Total Phenolic Content of Moringa oleifera Leaves in Two Stages of Maturity

Antioxidant Activity and Total Phenolic Content of Moringa oleifera Leaves in Two Stages of Maturity

Pre and Post-Treatment Effects: Estimation of Serum Testosterone and Lipid Peroxidation Levels on Moringa olifera Extract Induced Cadmium Exposed Rats

Flavonoid constituents of Dobera glabra leaves: amelioration impact against CCl4-induced changes in the genetic materials in male rats

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Product

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Flavonoid constituents of Dobera glabra leaves: amelioration impact against CCl₄-induced changes in the genetic materials in male rats