Chemopreventive Synergism between Green Tea Extract and Curcumin in Patients with Potentially Malignant Oral Disorders: A Double-blind, Randomized Preliminary Study

Neetha, Mellekatte C; Panchaksharappa, Mamatha Gowda; Pattabhiramasastry, Shashikala; Shivaprasad, Nandish V; Venkatesh, Usha

doi:10.5005/jp-journals-10024-2823

Cited by 20 publications

(17 citation statements)

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“…The clinical response rate after supplementation was determined for the combination of green tea polyphenols and curcumin (65%) in comparison to curcumin alone (11.55%) and green tea alone (7.35%), respectively. The expressions of Ki-67, P53 and cyclin D1 were downregulated in the samples collected after the experiment [231]. Anti-cancer properties of EGCG were also observed in colon carcinoma clinical trials.…”

Section: Clinical Trials Involving Natural Compoundsmentioning

confidence: 71%

Molecular Targets of Natural Compounds with Anti-Cancer Properties

Kubczak

Szustka

Rogalińska

2021

IJMS

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Cancer is the second leading cause of death in humans. Despite rapid developments in diagnostic methods and therapies, metastasis and resistance to administrated drugs are the main obstacles to successful treatment. Therefore, the main challenge should be the diagnosis and design of optimal therapeutic strategies for patients to increase their chances of responding positively to treatment and increase their life expectancy. In many types of cancer, a deregulation of multiple pathways has been found. This includes disturbances in cellular metabolism, cell cycle, apoptosis, angiogenesis, or epigenetic modifications. Additionally, signals received from the microenvironment may significantly contribute to cancer development. Chemical agents obtained from natural sources seem to be very attractive alternatives to synthetic compounds. They can exhibit similar anti-cancer potential, usually with reduced side effects. It was reported that natural compounds obtained from fruits and vegetables, e.g., polyphenols, flavonoids, stilbenes, carotenoids and acetogenins, might be effective against cancer cells in vitro and in vivo. Several published results indicate the activity of natural compounds on protein expression by its influence on transcription factors. They could also be involved in alterations in cellular response, cell signaling and epigenetic modifications. Such natural components could be used in our diet for anti-cancer protection. In this review, the activities of natural compounds, including anti-cancer properties, are described. The influence of natural agents on cancer cell metabolism, proliferation, signal transduction and epigenetic modifications is highlighted.

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Section: Clinical Trials Involving Natural Compoundsmentioning

confidence: 71%

Molecular Targets of Natural Compounds with Anti-Cancer Properties

Kubczak

Szustka

Rogalińska

2021

IJMS

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“…For instance, in 2011, Kim et al reported that curcumin suppressed the expression of salivary pro‐inflammatory cytokines such as IL‐6, IL‐7, TNF‐α, granulocyte‐macrophage colony‐stimulating factor, and IκB kinase beta kinase in head and neck cancer (HNC) patients (S. G. Kim et al, 2011). Accumulating evidence from the past years have suggested the potential anti‐neoplastic activity of curcumin against HNCs, including premalignant conditions of the oral cavity, such as oral submucous fibrosis (OSMF), oral leukoplakia, oral mucositis, and potentially malignant oral disorders (Delavarian et al, 2019; Kuriakose et al, 2016; Lanjekar et al, 2020; Neetha, Panchaksharappa, Pattabhiramasastry, Shivaprasad, & Venkatesh, 2020; Pinheiro et al, 2019; Piyush, Mahajan, Singh, Ghosh, & Gupta, 2019; Rai, Kaur, Gombra, Hasan, & Kumar, 2019; Saran et al, 2018). Topical application of curcumin exhibited significant therapeutic effect in OSMF patients, especially in combination with triamcinolone and hyaluronidase (Lanjekar et al, 2020).…”

Section: Clinical Studies With Curcuminmentioning

confidence: 99%

“…HNCs, including premalignant conditions of the oral cavity, such as oral submucous fibrosis (OSMF), oral leukoplakia, oral mucositis, and potentially malignant oral disorders(Delavarian et al, 2019;Kuriakose et al, 2016;Lanjekar et al, 2020;Neetha, Panchaksharappa, Pattabhiramasastry, Shivaprasad, & Venkatesh, 2020;Pinheiro et al, 2019;Piyush, Mahajan, Singh, Ghosh, & Gupta, 2019;Rai, Kaur, Gombra, Hasan, & Kumar, 2019;Saran et al, 2018). Topical application of curcumin exhibited significant therapeutic effect in OSMF patients, especially in combination with triamcinolone and hyaluronidase(Lanjekar et al, 2020).…”

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confidence: 99%

Current clinical developments in curcumin‐based therapeutics for cancer and chronic diseases

Kumar

Harsha

Dey

et al. 2021

Phytotherapy Research

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Funding information DAICENTERThe last decade has seen an unprecedented rise in the prevalence of chronic diseases worldwide. Different mono-targeted approaches have been devised to treat these multigenic diseases, still most of them suffer from limited success due to the offtarget debilitating side effects and their inability to target multiple pathways. Hence a safe, efficacious, and multi-targeted approach is the need for the hour to circumvent these challenging chronic diseases. Curcumin, a natural compound extracted from the rhizomes of Curcuma longa, has been under intense scrutiny for its wide medicinal and biological properties. Curcumin is known to manifest antibacterial, antiinflammatory, antioxidant, antifungal, antineoplastic, antifungal, and proapoptotic effects. A plethora of literature has already established the immense promise of curcuminoids in the treatment and clinical management of various chronic diseases like cancer, cardiovascular, metabolic, neurological, inflammatory, and infectious diseases. To date, more than 230 clinical trials have opened investigations to understand the pharmacological aspects of curcumin in human systems. Still, further randomized clinical studies in different ethnic populations warrant its transition to a marketed drug. This review summarizes the results from different clinical trials of curcuminbased therapeutics in the prevention and treatment of various chronic diseases.

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“…Phytochemicals are predominantly attractive because of their availability, low toxicity and absence of serious adverse reactions [ 14 , 15 ]. Furthermore, several clinical trials have reported that natural compounds tested either as single agent or in combination with standard chemotherapeutic drugs improve sensitivity to chemotherapy and radiotherapy along with the survival of patients [ 16 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Chalcone-Acridine Hybrid Suppresses Melanoma Cell Progression via G2/M Cell Cycle Arrest, DNA Damage, Apoptosis, and Modulation of MAP Kinases Activity

Gazdova

Michalková

Kello

et al. 2022

IJMS

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This study was focused on investigating the antiproliferative effects of chalcone hybrids in melanoma cancer cells. Among seven chalcone hybrids, the chalcone-acridine hybrid 1C was the most potent and was selected for further antiproliferative mechanism studies. This in vitro study revealed the potent antiproliferative effect of 1C via cell cycle arrest and apoptosis induction. Cell cycle arrest at the G2/M phase was associated with modulation of expression or phosphorylation of specific cell cycle-associated proteins (cyclin B1, p21, and ChK1), tubulins, as well as with the activation of the DNA damage response pathway. Chalcone 1C also induced apoptosis accompanied by mitochondrial dysfunction evidenced by a decrease in mitochondrial membrane potential, increase in Bax/Bcl-xL ratio and cytochrome c release followed by caspase 3/7 activation. In addition, increased phosphorylation of MAP kinases (Erk1/2, p38 and JNK) was observed in chalcone 1C-treated melanoma cells. The strong antiproliferative activities of this chalcone-acridine hybrid suggest that it may be useful as an antimelanoma agent in humans.

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Chemopreventive Synergism between Green Tea Extract and Curcumin in Patients with Potentially Malignant Oral Disorders: A Double-blind, Randomized Preliminary Study

Cited by 20 publications

References 0 publications

Molecular Targets of Natural Compounds with Anti-Cancer Properties

Molecular Targets of Natural Compounds with Anti-Cancer Properties

Current clinical developments in curcumin‐based therapeutics for cancer and chronic diseases

Chalcone-Acridine Hybrid Suppresses Melanoma Cell Progression via G2/M Cell Cycle Arrest, DNA Damage, Apoptosis, and Modulation of MAP Kinases Activity

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