“…Eflornithine, a polyamine inhibitor which inhibits STAT‐3, can also potentiate the effects of IFNs, including TRAIL‐induced apoptosis, but has its own direct antiproliferative, antiangiogenic, and pro‐apoptotic effects for some tumors 121,122 . Eflornithine is another agent being used for the chemoprevention of a number of malignancies, including skin cancers, and, as with retinoids, the vitamin D3 analog, calcipotriol, and a nonspecific COX inhibitor, diclofenac, has been used both as a systemic medication and in topical preparations 123–125 …”