Chemoprevention of Skin Cancer

Hydroxyurea-associated squamous dysplasia

“…The chemopreventive qualities of low-dose oral retinoids have been demonstrated in patients who are immunosuppressed after transplant and can be considered in patients with chronic HU and squamous dysplasia. [63][64][65][66] Squamous dysplasia, a precursor state to a more aggressive condition of multiple squamous cell carcinomas in photoexposed areas, should be added to the well-known cutaneous toxicities of HU therapy.…”

The evidence for solid lipid nanoparticles mediated cell uptake of resveratrol

“…It is well known that signalling pathways involved in over-proliferation and reduced differentiation can induce skin cancer. Although skin cancer is one of the few types of cancers that has become more common in recent years, it is fortunately one of the most preventable and treatable types (Horn and Gordon, 2001). It is established that signalling pathways involved in over-proliferation and reduced differentiation can induce skin cancer.…”

Death receptors and their role in dermatology, with particular focus on tumor necrosis factor‐related apoptosis‐inducing ligand receptors

“…Eflornithine, a polyamine inhibitor which inhibits STAT‐3, can also potentiate the effects of IFNs, including TRAIL‐induced apoptosis, but has its own direct antiproliferative, antiangiogenic, and pro‐apoptotic effects for some tumors 121,122 . Eflornithine is another agent being used for the chemoprevention of a number of malignancies, including skin cancers, and, as with retinoids, the vitamin D3 analog, calcipotriol, and a nonspecific COX inhibitor, diclofenac, has been used both as a systemic medication and in topical preparations 123–125 …”