Death receptors and their role in dermatology, with particular focus on tumor necrosis factor‐related apoptosis‐inducing ligand receptors

Smith, Kathleen J.; Diwan, Hafeez; Skelton, Henry G.

doi:10.1046/j.1365-4362.2003.01712.x

Cited by 11 publications

(3 citation statements)

References 126 publications

(189 reference statements)

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“…Caffeoyl derivatives have been shown to have antiinflammatory and antioxidant effects (JE Kim et al, 2005;Park et al, 2009;dos Santos et al, 2010). TRAIL is known to be implicated in the inflammation and apoptosis in skin diseases (Smith et al, 2003;Vassina et al, 2005). Nevertheless, the effect of 3,4,5-triCQA on the TRAIL-induced apoptosis in keratinocytes, which may be involved in skin diseases, has not been studied.…”

Section: Discussionmentioning

confidence: 99%

“…Apoptosis of keratinocytes caused by skin-infiltrating T cells may be involved in the formation of eczema in atopic dermatitis (Trautmann et al, 2000(Trautmann et al, , 2001. The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily and has been implicated in the inflammation, immune response, and apoptosis in various skin diseases (Smith et al, 2003;Trautmann et al, 2000;Vassina et al, 2005). Increased expression of TRAIL is detected in T cells and monocytes in the peripheral blood and skin lesions in patients with atopic dermatitis (Vassina et al, 2005;Warnnissorn et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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3,4,5-Tricaffeoylquinic Acid Attenuates TRAIL-induced Apoptosis in Human Keratinocytes by Suppressing Apoptosis-related Protein Activation

Lee

Nam

Lee³

et al. 2015

Phytother. Res.

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Caffeoyl derivatives exhibit antiinflammatory and antioxidant effects. However, the effect of 3,4,5-tricaffeoylquinic acid on the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in keratinocytes that may be involved in skin diseases has not been studied. In this respect, we investigated the effect of 3,4,5-tricaffeoylquinic acid on TRAIL-induced apoptosis in human keratinocytes. 3,4,5-Tricaffeoylquinic acid and oxidant scavengers attenuated the decrease in the cytosolic levels of Bid, Bcl-2, and survivin proteins; the increase in the levels of cytosolic Bax, p53, and phosphorylated p53; the increase in the levels of phosphorylated p38; the increase in the mitochondrial levels of the voltage-dependent anion channel; loss of the mitochondrial transmembrane potential; the release of cytochrome c; activation of caspases (8, 9, and 3); cleavage of poly [ADP-ribose] polymerase-1; production of reactive oxygen species; the depletion of glutathione (GSH); nuclear damage; and cell death in keratinocytes treated with TRAIL. These results suggest that 3,4,5-tricaffeoylquinic acid may reduce TRAIL-induced apoptosis in human keratinocytes by suppressing the activation of the caspase-8 and Bid pathways and the mitochondria-mediated cell death pathway. The effect appears to be associated with the inhibitory effect on the production of reactive oxygen species and depletion of GSH. 3,4,5-Tricaffeoylquinic acid appears to be effective in the prevention of TRAIL-induced apoptosis-mediated skin diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

3,4,5-Tricaffeoylquinic Acid Attenuates TRAIL-induced Apoptosis in Human Keratinocytes by Suppressing Apoptosis-related Protein Activation

Lee

Nam

Lee³

et al. 2015

Phytother. Res.

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“…Procaspase‐9 is activated and then activates downstream caspases. The extrinsic pathway is regulated by members of the tumor necrosis factor (TNF) superfamily, of which six members are known so far, namely CD95 (Fas/APO‐1), TNF‐receptor1 (TNF‐R1), TNF receptor‐related apoptosis‐mediating protein (TRAMP) receptor, TNF‐related apoptosis‐inducing ligand receptor1 (TRAIL‐R1), TRAIL‐R2 and death receptor 6 (DR6) (13, 14). Binding of death receptors with their extracellular ligands results in the activation of molecules containing motifs known as death domain such as the Fas‐associated death domain protein (FADD).…”

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confidence: 99%