Chemoprevention of colonic aberrant crypt foci by Gynura procumbens in rats

Extract of the Bark of Bathysa cuspidataAttenuates the Development of Chemically-Induced Preneoplastic Colorectal Lesions in Rats

“…The high concentration of antioxidant compounds present in the B400 group could explain the reduction in preneoplastic lesions. Shwter et al (2014) evaluated the anticarcinogenic activity of the ethanolic extract of Gynura procumbens on colorectal cancer induced by azoxymethane in Sprague-Dawley rats. The doses of extract (250 and 500 mg/kg body weight) used decreased the incidence of ACF in the colons of the animals after 10 weeks of treatment.…”

“…Polyphenols and flavonoids may inhibit the carcinogenesis by affecting the molecular events in the initiation, promotion, and progression stages. The mechanisms used by these compounds to inhibit the carcinogenic process include antioxidant action, modulation of several protein functions, modulation of the secretion of protein kinases in tumor cell proliferation, induction of the expression of anticarcinogenic enzymes, inhibition of induction of cancer-promoting enzymes, activation of detoxifying enzymes, and increased cell-to-cell communication, among others (Cai et al 2004;Shwter et al 2014). This study demonstrated that the extract of the bark of B. cuspidata at 400 mg/kg for 15 weeks reduced preneoplastic colorectal lesions in an animal model of colon cancer.…”

Gynura procumbens: An Overview of the Biological Activities

“…The treatment has resulted in inhibition of cell proliferation and was observed to suppress the invasive and migratory abilities of the cancer cells (Wang et al, 2013). Recently, ethanolic extract of G. procumbens was shown to cause about 80% decrease in azoxymethane-induced aberrant crypt foci in rats which indicates potential in preventing colon cancer (Shwter et al, 2014). G. procumbens has also demonstrated its potential in preventing breast cancer.…”

Bioactive components and properties of ethanolic extract and its fractions from Gynura procumbens leaves

“…Extracts of this plant have pharmacological activities such as antihyperglycemic (Akowuah et al, 2002), anti-inflammatory (Iskander et al, 2002) and anti-hypertensive effects (Kim et al, 2006). Other studies have also reported that G. procumbens showed anticancer and antiproliferative actions (Kim et al, 2011;Nisa et al, 2012;Shwter et al, 2014). These actions have been attributed to the presence of saponins, flavonoids and terpenoids (Akowuah et al, 2002).…”