Chemoprevention by means of soy proteins and peptides – current status and future approaches: a review

Abstract

Epidemiological studies have shown that soy consumption is associated with lower incidence of various diseases, such as cancer. Over the past decades, soy proteins and derived peptides have been considered as potential preventive agents against the initiation, promotion and progression of cancer. Additionally, soybeans provide essential nutrients and abundant peptides and proteins with multiple bioactivities. Here, we specifically emphasise the chemoprevention property of several soy proteins/peptides, such as lectins, lunasin and protease inhibitors. Moreover, their anti-inflammatory and antioxidant properties, which have been demonstrated to be associated with chemopreventive properties, are addressed here. Furthermore, computational methods applied in this field are reviewed. Researchers navigate a large volume of data to understand the interactions among the genome, cellular molecules, dietary interventions, medical treatments and diseases. Numerous powerful tools have been recommended for designing an optimal strategy for future anti-cancer treatments with precise diagnosis and individualised approaches.

Influence of transglutaminase‐assisted ultrasound treatment on the structure and functional properties of soy protein isolate

“…Soy protein isolate (SPI) contains at lowest 90% protein (dry basis) and is a good substitute for meat protein because of its low-cost, less allergenic, and well-balanced essential amino acid composition (Day, 2013). SPI was reported to possess a myriad of health benefits, such as anticarcinogenic, antiinflammatory, and antioxidative, reducing cholesterol level (Jia, Tian, Zhang, Fan, & Zhao, 2019) and the risk of hyperlipidemia (Nishinari, Fang, Guo, & Phillips, 2014), inhibiting the promotion of liver tumors in mice fed a high-fat liquid diet (Eller & Reimer, 2010), which could offer novel applications in chemoprevention or adjunctive treatments (Chen & Hsieh, 2019). Because of its biodegradability, unique structural properties, and good processing performance, SPI is widely used as the biodegradable composite films (Jiang, Tang, Wen, Li, & Yang, 2007;Wang et al, 2014) and the carrier material in encapsulation of bioactive flavonoids in recent years (Wang & Wang, 2015).…”