Seed peptide lunasin ameliorates obesity-induced inflammation and regulates immune responses in C57BL/6J mice fed high-fat diet

Hsieh, Chia Chien; Wang, Yen Fang; Lin, Pin Yu; Peng, Shih Han; Chou, Mei Jia

doi:10.1016/j.fct.2020.111908

Cited by 16 publications

(10 citation statements)

References 46 publications

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“…The effects of LES (0.5-25 µg protein/mL) and lunasin (1-500 µM) on cell proliferation after 24 h of treatment under basal conditions are shown in Figure 2. Previous findings show that synthetic lunasin stimulates EL4 proliferation irrespective of the presence or absence of obesity-inducing factors [37]. However, in our study, lunasin did not cause any effect on cell proliferation (Figure 2A).…”

Section: Effects Of Lunasin-enriched Soybean Extract (Les) In Raw2647...contrasting

confidence: 70%

Evaluation of the Multifunctionality of Soybean Proteins and Peptides in Immune Cell Models

Paterson

Fernández-Tomé

Galvez³

et al. 2023

Nutrients

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Inflammatory and oxidative processes are tightly regulated by innate and adaptive immune systems, which are involved in the pathology of a diversity of chronic diseases. Soybean peptides, such as lunasin, have emerged as one of the most hopeful food-derived peptides with a positive impact on health. The aim was to study the potential antioxidant and immunomodulatory activity of a lunasin-enriched soybean extract (LES). The protein profile of LES was characterized, and its behavior under simulated gastrointestinal digestion was evaluated. Besides its in vitro radical scavenging capacity, LES and lunasin’s effects on cell viability, phagocytic capacity, oxidative stress, and inflammation-associated biomarkers were investigated in both RAW264.7 macrophages and lymphocytes EL4. Lunasin and other soluble peptides enriched after aqueous solvent extraction partially resisted the action of digestive enzymes, being potentially responsible for the beneficial effects of LES. This extract scavenged radicals, reduced reactive oxygen species (ROS) and exerted immunostimulatory effects, increasing nitric oxide (NO) production, phagocytic activity, and cytokine release in macrophages. Lunasin and LES also exerted dose-dependent immunomodulatory effects on EL4 cell proliferation and cytokine production. The modulatory effects of soybean peptides on both immune cell models suggest their potential protective role against oxidative stress, inflammation, and immune response-associated disorders.

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Section: Effects Of Lunasin-enriched Soybean Extract (Les) In Raw2647...contrasting

confidence: 70%

Evaluation of the Multifunctionality of Soybean Proteins and Peptides in Immune Cell Models

Paterson

Fernández-Tomé

Galvez³

et al. 2023

Nutrients

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“…At present, there is a growing amount of evidence that shows the neuroprotective role of antioxidants in gliosis ( Table 1 and Figure 1 ). In recent studies, it has been proposed that lunasin has a bioactive action on obesity, since, in studies carried out in mice, it mediates the anti-inflammatory response and its mechanism of action helps to obtain a better response from type 1 helper T cells against low immune activity caused by obesity [ 117 , 118 , 119 ]. In the study of Sharma et al, they showed that treatment with hydroethanolic hull extract of Juglans regia L. reverted the neuronal degeneration, spongiosis and gliosis in cerebral cortex of rats in a model of oxidative damage induced with isoprenaline.…”

Section: Protective Role Of Antioxidants In Gliosismentioning

confidence: 99%

Trends in Gliosis in Obesity, and the Role of Antioxidants as a Therapeutic Alternative

et al. 2022

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Obesity remains a global health problem. Chronic low-grade inflammation in this pathology has been related to comorbidities such as cognitive alterations that, in the long term, can lead to neurodegenerative diseases. Neuroinflammation or gliosis in patients with obesity and type 2 diabetes mellitus has been related to the effect of adipokines, high lipid levels and glucose, which increase the production of free radicals. Cerebral gliosis can be a risk factor for developing neurodegenerative diseases, and antioxidants could be an alternative for the prevention and treatment of neural comorbidities in obese patients. Aim: Identify the immunological and oxidative stress mechanisms that produce gliosis in patients with obesity and propose antioxidants as an alternative to reducing neuroinflammation. Method: Advanced searches were performed in scientific databases: PubMed, ProQuest, EBSCO, and the Science Citation index for research on the physiopathology of gliosis in obese patients and for the possible role of antioxidants in its management. Conclusion: Patients with obesity can develop neuroinflammation, conditioned by various adipokines, excess lipids and glucose, which results in an increase in free radicals that must be neutralized with antioxidants to reduce gliosis and the risk of long-term neurodegeneration.

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“…100 Moreover, the seed peptide lunasin from natural cereals and legumes can improve obesity-induced inflammation in mice, nevertheless, it has been evident that this effect is gender-specific. 101…”

Section: Anti-obesitymentioning

confidence: 99%

Bioactive peptides of plant origin: distribution, functionality, and evidence of benefits in food and health

et al. 2022

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Seed peptide lunasin ameliorates obesity-induced inflammation and regulates immune responses in C57BL/6J mice fed high-fat diet

Cited by 16 publications

References 46 publications

Evaluation of the Multifunctionality of Soybean Proteins and Peptides in Immune Cell Models

Evaluation of the Multifunctionality of Soybean Proteins and Peptides in Immune Cell Models

Trends in Gliosis in Obesity, and the Role of Antioxidants as a Therapeutic Alternative

Bioactive peptides of plant origin: distribution, functionality, and evidence of benefits in food and health

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