Chemolysis of calcium oxalate stones: study in vitro and possible clinical application

Кустов, А. В.; Шевырин, А. А.; Стрельников, А. И.; Smirnov, Alexander; Trostin, V. N.

doi:10.1007/s00240-011-0429-z

Cited by 8 publications

(2 citation statements)

References 14 publications

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“…The widely used drugs for preventing formation of new stones are potassium citrate or potassium/ magnesium citrate mixtures [4,6,20]. They allow to increase urinary pH, magnesium and citrate urine excretion, to bind calcium ions into soluble Ca-citrate complexes to avoid crystallization and dissolve residual fragments [21]. Our very recent study for the group of thirty COH stone formers has indicated that hypocitraturia is a frequent disorder afflicting about 90% of patients.…”

Section: Discussionmentioning

confidence: 99%

New step-by-step algorithms for diagnosis of calcium oxalate urolithiasis based on a qualitative mineralogical composition of calculi

Кустов¹,

Стрельников²,

Airapetyan³

et al. 2015

Clin Nephrol Urol Sci

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Background: This paper is focused on diagnosis of calcium oxalate renal stones as the most frequent form of urolithiasis in a human society. Materials and methods: A systematic review of the experimental and clinical studies on calcium oxalate urolithiasis performed during the last two decades has been used to elaborate new programs for diagnosing this frequent disorder. Results: We have proposed new simple step-by-step algorithms for the diagnostics of calcium oxalate stones which take into account the qualitative mineralogical composition of a calculus and results of the biochemical tests of urine and blood of a patient. The frequency of stone formation, the monohydrate/ dihydrate ratio and amount of minor components have been determined to be the key parameters defining the strategy of a metabolic evaluation. Conclusions:The concept proposed here is closed on basic measures clear for any physician, not too expensive for a patient and it may be realized in any clinics if the information about the exact mineralogical composition of a calculus is available.

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Section: Discussionmentioning

confidence: 99%

New step-by-step algorithms for diagnosis of calcium oxalate urolithiasis based on a qualitative mineralogical composition of calculi

Кустов¹,

Стрельников²,

Airapetyan³

et al. 2015

Clin Nephrol Urol Sci

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“…The causes of kidney stone formation are well understood based on previous findings from studies over the past decades [13,14]. Research has shown that C, O, N, P, and Ca are major components of kidney stones, while other elements, such as Sr, Cu, Fe, Zn, Pb, Cr, and Mn, are found in trace amounts [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Preliminary Data on Geochemical Characteristics of Major and Trace Elements in Typical Biominerals: From the Perspective of Human Kidney Stones

et al. 2021

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The chemical composition of biominerals is essential for understanding biomineral formation and is regarded as an attractive subject in bio-mineralogical research on human kidney stones (urinary calculi). In order to obtain more geochemically interpreted data on biogenic minerals, mineralogical compositions and major and trace element concentrations of sixty-six kidney stone samples derived from kidney stone removal surgeries were measured. Infrared spectroscopy results showed that calcium oxalate monohydrate (COM) and calcium oxalate dihydrate (COD) were the two main mineral components of kidney stones. Geochemical results indicated that major and trace element concentrations were present in the following order: Ca > Mg > Na > K > Zn > Fe > Pb > Ba > Cu > Ti > Mo > Cd > Cr. With the exception of Ca, Mg was the second-most abundant element. Zn exhibited higher concentrations relative to other trace elements, which suggests a potential substitution of calcium by metal ions with a similar charge and radius rather than by metals in kidney stone formation. Pb appeared in significantly higher concentrations than in previous studies, which indicates Pb enrichment in the environment. In order to discern multi-element relationships within kidney stones, principal component analysis was applied. Three principal components (PCs, eigenvalues >1) were extracted to explain 64.4% of the total variance. The first component exhibited positively correlated Na-Zn-Cr-Mo-Cd-Pb, while the second component exhibited more positively weighted Mg-K-Ba-Ti. Fe-Cu demonstrated a positive correlation in the third component. This study suggests that Ca exhibits a preference for uptake by oxalates during human urinary stone crystallization, while other alkali metals and alkaline earth metals precipitate with phosphate.

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Hyperoxaluria is related to whewellite and hypercalciuria to weddellite: What happens when crystalline conversion occurs?

Bazin

Leroy

Tielens

et al. 2016

Comptes Rendus. Chimie

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International audienceWhile calcium oxalate monohydrate (whewellite: CaC₂ O ₄ H ₂ O) kidney stones are related to hyperoxaluria, calcium oxalate dihydrate (weddellite: CaC ₂ O ₄(2 + x)H ₂ O) ones are mainly associated with hypercalciuria. Crystalline conversion from weddellite to whe-wellite introduces a contradiction between Fourier transform infrared (FTIR) spectra which indicate the presence of whewellite and the fact that bipyramid crystallites, a morphology specific of weddellite, can be observed. It constitutes thus a major problem for clinicians as hyperoxaluria and hypercalciuria are associated with very different aetiologies and treatments. In this contribution, the complete set of data including neutron diffraction experiments, observations through a last generation field emission scanning electron microscope as well as 3D and 2D cross-section visualisations derived from the mComputed Tomography measurements seems to explain some particular features observed on FTIR spectra related to the crystalline conversion from weddellite to whewellite. The structural hypothesis which is proposed is related to the formation of amorphous whewellite, a new polymorph recently synthesised. Thus, in such cases, special attention should be paid to the stone morphology (and not FTIR spectrum), which is a major element for clinical diagnosis as already underlined for other types of urinary calculi

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Chemolysis of calcium oxalate stones: study in vitro and possible clinical application

Cited by 8 publications

References 14 publications

New step-by-step algorithms for diagnosis of calcium oxalate urolithiasis based on a qualitative mineralogical composition of calculi

New step-by-step algorithms for diagnosis of calcium oxalate urolithiasis based on a qualitative mineralogical composition of calculi

Preliminary Data on Geochemical Characteristics of Major and Trace Elements in Typical Biominerals: From the Perspective of Human Kidney Stones

Hyperoxaluria is related to whewellite and hypercalciuria to weddellite: What happens when crystalline conversion occurs?

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